The Genomic and Cellular Foundations of Animal Origins

Untitled work

Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606 · see citing works

An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System

Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910 · see citing works

Animals in a bacterial world, a new imperative for the life sciences

McFall‐Ngai, M., Hadfield, M. G. ‏., Bosch, T. C. G., Carey, H. V., Domazet‐Lošo, T., Douglas, A. E., Dubilier, N., Eberl, G., Fukami, T., Gilbert, S. F., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218525110 · Cited by 2,741 · see citing works

SNAREs — engines for membrane fusion

Jahn, R., & Scheller, R. H. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2002 · Cited by 2,635 · see citing works

Broad phylogenomic sampling improves resolution of the animal tree of life

Dunn, C. W., Hejnol, A., Matus, D. Q., Pang, K., Browne, W. E., Smith, S. A., Seaver, E., Rouse, G. W., Obst, M., Edgecombe, G. D., et al. (2008) · Nature · doi:10.1038/nature06614 · Cited by 1,921 · see citing works

Comparative Genomics of the Eukaryotes

Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., et al. (2000) · Science · doi:10.1126/science.287.5461.2204 · Cited by 1,698 · see citing works

Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases

Shiu, S., & Bleecker, A. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181141598 · Cited by 1,472 · see citing works

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

King, N., Westbrook, M. J., Young, S. L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., et al. (2008) · Nature · doi:10.1038/nature06617 · Cited by 1,139 · see citing works

Resolving difficult phylogenetic questions: Why more sequences are not enough

Philippe, H., Brinkmann, H., Lavrov, D. V., Littlewood, D. T. J., Manuel, M., Wörheide, G., & Baurain, D. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000602 · Cited by 1,129 · see citing works

Cadherins in development: cell adhesion, sorting, and tissue morphogenesisPreprint

Halbleib, J. M., & Nelson, W. J. (2006) · Genes & Development · doi:10.1101/gad.1486806 · Cited by 1,063 · see citing works

The Amphimedon queenslandica genome and the evolution of animal complexity

Srivastava, M., Simakov, O., Chapman, J., Fahey, B., Gauthier, M. E. A., Mitros, T., Richards, G. S., Conaco, C., Dacre, M., Hellsten, U., et al. (2010) · Nature · doi:10.1038/nature09201 · Cited by 1,049 · see citing works

Late-Neoproterozoic Deep-Ocean Oxygenation and the Rise of Animal Life

Canfield, D. E., Poulton, S. W., & Narbonne, G. M. (2007) · Science · doi:10.1126/science.1135013 · Cited by 1,000 · see citing works

Src family kinases, key regulators of signal transduction

Parsons, S. J., & Parsons, J. T. (2004) · Oncogene · doi:10.1038/sj.onc.1208160 · Cited by 942 · see citing works

The Ectocarpus genome and the independent evolution of multicellularity in brown algae

Cock, J., Sterck, L., Rouzé, P., Scornet, D., Allen, A., Amoutzias, G., Anthouard, V., Artiguenave, F., Aury, J., Badger, J. H., et al. (2010) · Nature · doi:10.1038/nature09016 · Cited by 933 · see citing works

Integrin signalling at a glance

Harburger, D. S., & Calderwood, D. (2008) · Journal of Cell Science · doi:10.1242/jcs.018093 · Cited by 902 · see citing works

Estimating the timing of early eukaryotic diversification with multigene molecular clocks

Parfrey, L. W., Lahr, D. J. G., Knoll, A. H., & Katz, L. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110633108 · Cited by 899 · see citing works

The Trichoplax genome and the nature of placozoans

Srivastava, M., Begovic, E., Chapman, J., Putnam, N. H., Hellsten, U., Kawashima, T., Kuo, A., Mitros, T., Salamov, A., Carpenter, M. L., et al. (2008) · Nature · doi:10.1038/nature07191 · Cited by 889 · see citing works

Role of Src expression and activation in human cancer

Irby, R., & Yeatman, T. J. (2000) · Oncogene · doi:10.1038/sj.onc.1203912 · Cited by 856 · see citing works

Early animal evolution: emerging views from comparative biology and geology

Knoll, A. H., & Carroll, S. B. (1999) · Science · doi:10.1126/science.284.5423.2129 · Cited by 821 · see citing works

Ferruginous Conditions Dominated Later Neoproterozoic Deep-Water Chemistry

Canfield, D. E., Poulton, S. W., Knoll, A. H., Narbonne, G. M., Ross, G., Goldberg, T., & Strauss, H. (2008) · Science · doi:10.1126/science.1154499 · Cited by 789 · see citing works

Fossil steroids record the appearance of Demospongiae during the Cryogenian period

Love, G. D., Grosjean, E., Stalvies, C., Fike, D. A., Grotzinger, J. P., Bradley, A. S., Kelly, A. E., Bhatia, M., Meredith, W., Snape, C. E., et al. (2009) · Nature · doi:10.1038/nature07673 · Cited by 731 · see citing works

Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals

Grimson, A., Srivastava, M., Fahey, B., Woodcroft, B. J., Chiang, H. R., King, N., Degnan, B. M., Rokhsar, D. S., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07415 · Cited by 725 · see citing works

The Ediacara biota: Neoproterozoic origin of animals and their ecosystems

Narbonne, G. M. (2005) · Annual Review of Earth and Planetary Sciences · doi:10.1146/annurev.earth.33.092203.122519 · Cited by 714 · see citing works

Phylogenomics Revives Traditional Views on Deep Animal Relationships

Philippe, H., Derelle, R., Lopez, P., Pick, K., Borchiellini, C., Boury-Esnault, N., Vacelet, J., Renard, E., Houliston, E., Quéinnec, E., et al. (2009) · Current Biology · doi:10.1016/j.cub.2009.02.052 · Cited by 695 · see citing works

Src in cancer: deregulation and consequences for cell behaviour

Frame, M. C. (2002) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(02)00040-9 · Cited by 682 · see citing works

Tyrosine phosphorylation: thirty years and counting

Hunter, T. R. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.028 · Cited by 655 · see citing works

Monophyletic Origins of the Metazoa: an Evolutionary Link with Fungi

Wainright, P. O., Hinkle, G., Sogin, M. L., & Stickel, S. K. (1993) · Science · doi:10.1126/science.8469985 · Cited by 653 · see citing works

The timing of eukaryotic evolution: Does a relaxed molecular clock reconcile proteins and fossils?

Douzery, E. J. P., Snell, E. A., Bapteste, E., Delsuc, F., & Philippe, H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403984101 · Cited by 638 · see citing works

The cadherin superfamily: diversity in form and function

Angst, B. D., Marcozzi, C., & Magee, A. I. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.4.629 · Cited by 619 · see citing works

WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra

Hobmayer, B., Rentzsch, F., Kuhn, K., Happel, C. M., von Laue, C. C., Snyder, P., Rothbächer, U., & Holstein, T. W. (2000) · Nature · doi:10.1038/35025063 · Cited by 599 · see citing works

Untitled work

(1940) · Andalas University Repository (Andalas University) · Cited by 591 · see citing works

A molecular timescale of eukaryote evolution and the rise of complex multicellular life

Hedges, S. B., Blair, J. E., Venturi, M. L., & Shoe, J. L. (2004) · BMC Evolutionary Biology · doi:10.1186/1471-2148-4-2 · Cited by 578 · see citing works

Planar Cell Polarity Signaling: From Fly Development to Human Disease

Simons, M., & Mlodzik, M. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091432 · Cited by 570 · see citing works

The Multiple Origins of Complex Multicellularity

Knoll, A. H. (2011) · Annual Review of Earth and Planetary Sciences · doi:10.1146/annurev.earth.031208.100209 · Cited by 562 · see citing works

Multigene Analyses of Bilaterian Animals Corroborate the Monophyly of Ecdysozoa, Lophotrochozoa, and Protostomia

Philippe, H., Lartillot, N., & Brinkmann, H. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msi111 · Cited by 551 · see citing works

The Unicellular Ancestry of Animal Development

King, N. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.08.010 · Cited by 482 · see citing works

The deep evolution of metazoan microRNAs

Wheeler, B. M., Heimberg, A. M., Moy, V. N., Sperling, E. A., Holstein, T. W., Heber, S., & Peterson, K. J. (2009) · Evolution & Development · doi:10.1111/j.1525-142x.2008.00302.x · Cited by 473 · see citing works

Estimating metazoan divergence times with a molecular clock

Peterson, K. J., Lyons, J. B., Nowak, K. S., Takacs, C. M., Wargo, M. J., & McPeek, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401670101 · Cited by 461 · see citing works

Evolution of Key Cell Signaling and Adhesion Protein Families Predates Animal Origins

King, N., Hittinger, C. T., & Carroll, S. B. (2003) · Science · doi:10.1126/science.1083853 · Cited by 424 · see citing works

Gastrulation: from cells to embryo

(2005) · Choice Reviews Online · doi:10.5860/choice.42-4013 · Cited by 414 · see citing works

Solution Structure of the Epithelial Cadherin Domain Responsible for Selective Cell Adhesion

Overduin, M., Harvey, T. S., Bagby, S., Tong, K. I., Yau, P., Takeichi, M., & Ikura, M. (1995) · Science · doi:10.1126/science.7824937 · Cited by 414 · see citing works

The fossil record and the early evolution of the Metazoa

Morris, S. C. (1993) · Nature · doi:10.1038/361219a0 · Cited by 389 · see citing works

Origin of Bilaterian Body Plans: Evolution of Developmental Regulatory Mechanisms

Davidson, E. H., Peterson, K. J., & Cameron, R. A. (1995) · Science · doi:10.1126/science.270.5240.1319 · Cited by 381 · see citing works

Microbial Factor-Mediated Development in a Host-Bacterial Mutualism

Koropatnick, T. A., Engle, J. T., Apicella, M. A., Stabb, E. V., Goldman, W. E., & McFall‐Ngai, M. (2004) · Science · doi:10.1126/science.1102218 · Cited by 379 · see citing works

Structure and Mechanism of Cadherins and Catenins in Cell-Cell Contacts

Pokutta, S., & Weis, W. I. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104241 · Cited by 375 · see citing works

Uniting Germline and Stem Cells: The Function of Piwi Proteins and the piRNA Pathway in Diverse Organisms

Juliano, C., Wang, J., & Lin, H. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132541 · Cited by 374 · see citing works

Animal Evolution and the Molecular Signature of Radiations Compressed in Time

Rokas, A., Krüger, D., & Carroll, S. B. (2005) · Science · doi:10.1126/science.1116759 · Cited by 371 · see citing works

Phosphotyrosine Signaling: Evolving a New Cellular Communication System

Lim, W. A., & Pawson, T. J. (2010) · Cell · doi:10.1016/j.cell.2010.08.023 · Cited by 344 · see citing works

Six major steps in animal evolution: Are we derived sponge larvae?

Nielsen, C. (2008) · Evolution & Development · doi:10.1111/j.1525-142x.2008.00231.x · Cited by 343 · see citing works

Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling

Clarke, M., Lohan, A. J., Liu, B. A., Lagkouvardos, I., Roy, S. W., Zafar, N., Bertelli, C., Schilde, C., Kianianmomeni, A., Bürglin, T. R., et al. (2013) · Genome biology · doi:10.1186/gb-2013-14-2-r11 · Cited by 331 · see citing works

The Closest Unicellular Relatives of Animals

Lang, B. F., O'Kelly, C., Nerad, T., Gray, M. W., & Burger, G. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01187-9 · Cited by 326 · see citing works

Early evolution of animal cell signaling and adhesion genes

Nichols, S., Dirks, W., Pearse, J. S., & King, N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604065103 · Cited by 322 · see citing works

The Origins of Multicellularity and the Early History of the Genetic Toolkit For Animal Development

Rokas, A. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091513 · Cited by 312 · see citing works

The Protistan Origins of Animals and Fungi

Steenkamp, E. T., Wright, J., & Baldauf, S. L. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msj011 · Cited by 307 · see citing works

Receptor-like kinases shape the plant

Smet, I. D., Voß, U., Jürgens, G., & Beeckman, T. (2009) · Nature Cell Biology · doi:10.1038/ncb1009-1166 · Cited by 301 · see citing works

A Post-Synaptic Scaffold at the Origin of the Animal Kingdom

Sakarya, O., Armstrong, K. A., Adamska, M., Adamski, M., Wang, I.-F., Tidor, B., Degnan, B. M., Oakley, T. H., & Kosik, K. S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000506 · Cited by 291 · see citing works

Origin and diversification of the basic helix-loop-helix gene family in metazoans: insights from comparative genomics

Simionato, E., Ledent, V., Richards, G. S., Thomas‐Chollier, M., Kerner, P., Coornaert, D., Degnan, B. M., & Vervoort, M. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-33 · Cited by 286 · see citing works

An overview of the genome of Nostoc punctiforme, a multicellular, symbiotic cyanobacterium

Meeks, J. C., Elhai, J., Thiel, T., Potts, M., Larimer, F. W., Lamerdin, J. E., Predki, P. F., & Atlas, R. (2001) · Photosynthesis Research · doi:10.1023/a:1013840025518 · Cited by 285 · see citing works

Kunstformen der Natur

Haeckel, E., & Bibliographisches Institut (Leipzig, G. (1899) · doi:10.5962/bhl.title.102214 · Cited by 283 · see citing works

Premetazoan genome evolution and the regulation of cell differentiation in the choanoflagellate Salpingoeca rosetta

Fairclough, S. R., Chen, Z., Kramer, E., Zeng, Q., Young, S., Robertson, H. M., Begović, E., Richter, D. J., Russ, C., Westbrook, M. J., et al. (2013) · Genome biology · doi:10.1186/gb-2013-14-2-r15 · Cited by 279 · see citing works

Cell differentiation and morphogenesis in the colony-forming choanoflagellate Salpingoeca rosetta

Dayel, M. J., Alegado, R. A., Fairclough, S. R., Levin, T. C., Nichols, S. A., McDonald, K., & King, N. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.06.003 · Cited by 277 · see citing works

Sponge paraphyly and the origin of Metazoa

Borchiellini, C., Manuel, M., Alivon, E., Boury-Esnault, N., Vacelet, J., & Le Parco, Y. (2001) · Journal of Evolutionary Biology · doi:10.1046/j.1420-9101.2001.00244.x · Cited by 275 · see citing works

Genesis and Expansion of Metazoan Transcription Factor Gene Classes

Larroux, C., Luke, G. N., Koopman, P. A., Rokhsar, D. S., Shimeld, S. M., & Degnan, B. M. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn047 · Cited by 275 · see citing works

A Phylogenomic Investigation into the Origin of Metazoa

Ruiz‐Trillo, I., Roger, A. J., Burger, G., Gray, M. W., & Lang, B. F. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn006 · Cited by 269 · see citing works

Multigene Phylogeny of Choanozoa and the Origin of Animals

Shalchian‐Tabrizi, K., Minge, M. A., Espelund, M., Orr, R. J. S., Ruden, T. A., Jakobsen, K. S., & Cavalier‐Smith, T. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002098 · Cited by 263 · see citing works

Concatenated Analysis Sheds Light on Early Metazoan Evolution and Fuels a Modern “Urmetazoon” Hypothesis

Schierwater, B., Eitel, M., Jakob, W., Osigus, H.-J., Hadrys, H., Dellaporta, S. L., Kolokotronis, S.-O., & DeSalle, R. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000020 · Cited by 260 · see citing works

Wnt and TGF-β Expression in the Sponge Amphimedon queenslandica and the Origin of Metazoan Embryonic Patterning

Adamska, M., Degnan, S. M., Green, K. M., Adamski, M., Craigie, A., Larroux, C., & Degnan, B. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001031 · Cited by 257 · see citing works

Ancient origin of the integrin-mediated adhesion and signaling machinery

Sebé-Pedrós, A., Roger, A. J., Lang, B. F., King, N., & Ruiz‐Trillo, I. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002257107 · Cited by 250 · see citing works

A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals

Alegado, R. A., Brown, L. W., Cao, S., Dermenjian, R. K., Zuzow, R., Fairclough, S. R., Clardy, J., & King, N. (2012) · eLife · doi:10.7554/elife.00013 · Cited by 249 · see citing works

Increases in the Number of SNARE Genes Parallels the Rise of Multicellularity among the Green Plants

Sanderfoot, A. A. (2007) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.092973 · Cited by 247 · see citing works

An Ecological Theory for the Sudden Origin of Multicellular Life in the Late Precambrian

Stanley, S. M. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.5.1486 · Cited by 246 · see citing works

The Premetazoan Ancestry of Cadherins

Sigg, M. A., & King, N. (2008) · Science · doi:10.1126/science.1151084 · Cited by 239 · see citing works

A receptor tyrosine kinase from choanoflagellates: Molecular insights into early animal evolution

King, N., & Carroll, S. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261477698 · Cited by 234 · see citing works

Diverse evolutionary paths to cell adhesion

Sigg, M. A., & King, N. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.08.002 · Cited by 233 · see citing works

Type IV collagen in sponges, the missing link in basement membrane ubiquity*

Boute, N., Exposito, J., Boury‐Esnault, N., Vacelet, J., Noro, N., Miyazaki, K., Yoshizato, K., & Garrone, R. (1996) · Biology of the Cell · doi:10.1016/s0248-4900(97)86829-3 · Cited by 223 · see citing works

Possible animal-body fossils in pre-Marinoan limestones from South Australia

Maloof, A. C., Rose, C. V., Beach, R., Samuels, B. M., Calmet, C. C., Erwin, D. H., Poirier, G. R., Yao, N., & Simons, F. J. (2010) · Nature Geoscience · doi:10.1038/ngeo934 · Cited by 213 · see citing works

The protist, Monosiga brevicollis , has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan

Manning, G., Young, S. L., Miller, W. T., & Zhai, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801314105 · Cited by 211 · see citing works

Choanoflagellates, choanocytes, and animal multicellularity

Maldonado, M. (2004) · Invertebrate Biology · doi:10.1111/j.1744-7410.2004.tb00138.x · Cited by 207 · see citing works

The origins of multicellularity: a multi-taxon genome initiative

Ruiz‐Trillo, I., Burger, G., Holland, P. W. H., King, N., Lang, B. F., Roger, A. J., & Gray, M. W. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.01.005 · Cited by 206 · see citing works

Molecular phylogeny of choanoflagellates, the sister group to Metazoa

Carr, M., Leadbeater, B. S. C., Hassan, R., Nelson, M., & Baldauf, S. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801667105 · Cited by 205 · see citing works

A potential catalytic site revealed by the 1.7-Å crystal structure of the amino-terminal signalling domain of Sonic hedgehog

Hall, T. M. T., Porter, J. A., Beachy, P. A., & Leahy, D. J. (1995) · Nature · doi:10.1038/378212a0 · Cited by 198 · see citing works

Unexpected repertoire of metazoan transcription factors in the unicellular holozoan Capsaspora owczarzaki

Sebe-Pedros, A., de Mendoza, A., Lang, B. F., Degnan, B. M., & Ruiz-Trillo, I. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msq309 · Cited by 195 · see citing works

Origin of metazoan cadherin diversity and the antiquity of the classical cadherin/β-catenin complex

Nichols, S., Roberts, B., Richter, D. J., Fairclough, S. R., & King, N. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120685109 · Cited by 193 · see citing works

Thousands of Rab GTPases for the Cell Biologist

Diekmann, Y., Seixas, E., Gouw, M., Tavares-Cadete, F., Seabra, M. C., & Pereira‐Leal, J. B. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002217 · Cited by 189 · see citing works

Epithelium--The Primary Building Block for Metazoan Complexity

Tyler, S. (2003) · Integrative and Comparative Biology · doi:10.1093/icb/43.1.55 · Cited by 187 · see citing works

Innate Immune Defense of the Sponge Suberites domuncula against Bacteria Involves a MyD88-dependent Signaling Pathway

Wiens, M., Korzhev, M., Krasko, A., Thakur, N. L., Perović‐Ottstadt, S., Breter, H. J., Ushijima, H., Diehl‐Seifert, B., Müller, I. M., & Müller, W. E. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504049200 · Cited by 182 · see citing works

Sponge phylogeny, animal monophyly, and the origin of the nervous system: 18S rRNA evidence

Cavalier-Smith, T., Allsopp, M. T. E. P., Chao, E. E., Boury-Esnault, N., & Vacelet, J. (1996) · Canadian Journal of Zoology · doi:10.1139/z96-231 · Cited by 180 · see citing works

The NK homeobox gene cluster predates the origin of Hox genes.

Larroux, C., Fahey, B., Degnan, S. M., Adamski, M., Rokhsar, D. S., & Degnan, B. M. (2007) · Current Biology · doi:10.1016/j.cub.2007.03.008 · Cited by 173 · see citing works

Developmental expression of transcription factor genes in a demosponge: insights into the origin of metazoan multicellularity

Larroux, C., Fahey, B., Liubicich, D., Hinman, V. F., Gauthier, M., Gongora, M., Green, K., Wörheide, G., Leys, S. P., & Degnan, B. M. (2006) · Evolution & Development · doi:10.1111/j.1525-142x.2006.00086.x · Cited by 173 · see citing works

Phylogenetic-signal dissection of nuclear housekeeping genes supports the paraphyly of sponges and the monophyly of Eumetazoa

Sperling, E. A., Peterson, K. J., & Pisani, D. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp148 · Cited by 172 · see citing works

Evolution of the phospho-tyrosine signaling machinery in premetazoan lineages

Pincus, D., Letunić, I., Peer Bork, B., & Lim, W. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803161105 · Cited by 165 · see citing works

Sponge Genes Provide New Insight into the Evolutionary Origin of the Neurogenic Circuit

Richards, G. S., Simionato, E., Perron, M., Adamska, M., Vervoort, M., & Degnan, B. M. (2008) · Current Biology · doi:10.1016/j.cub.2008.06.074 · Cited by 165 · see citing works

Multicellular development in a choanoflagellate

Fairclough, S. R., Dayel, M. J., & King, N. (2010) · Current Biology · doi:10.1016/j.cub.2010.09.014 · Cited by 163 · see citing works

The Cambrian explosion: Animals or fossils?

Runnegar, B. (1982) · Journal of the Geological Society of Australia · doi:10.1080/00167618208729222 · Cited by 151 · see citing works

Evolution of sodium channels predates the origin of nervous systems in animals

Liebeskind, B. J., Hillis, D. M., & Zakon, H. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106363108 · Cited by 149 · see citing works

Non-Lithistid Fossil Demospongiae — Origins of their Palaeobiodiversity and Highlights in History of Preservation

Reitner, J., & Wörheide, G. (2002) · Systema Porifera · doi:10.1007/978-1-4615-0747-5_4 · Cited by 140 · see citing works

Structure and expression of conserved Wnt pathway components in the demosponge <i>Amphimedon queenslandica</i>

Adamska, M., Larroux, C., Adamski, M., Green, K., Lovas, E., Koop, D., Richards, G. S., Zwafink, C., & Degnan, B. M. (2010) · Evolution &amp; Development · doi:10.1111/j.1525-142x.2010.00435.x · Cited by 139 · see citing works

Embryogenesis and metamorphosis in a haplosclerid demosponge: Gastrulation and transdifferentiation of larval ciliated cells to choanocytes.

Leys, S. P., & Degnan, B. M. (2002) · Invertebrate Biology · doi:10.1111/j.1744-7410.2002.tb00058.x · Cited by 138 · see citing works

The evolutionary origin of hedgehog proteins

Adamska, M., Matus, D. Q., Adamski, M., Green, K., Rokhsar, D. S., Martindale, M. Q., & Degnan, B. M. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.010 · Cited by 137 · see citing works

Premetazoan Origin of the Hippo Signaling Pathway

Sebé-Pedrós, A., Zheng, Y., Ruiz‐Trillo, I., & Pan, D. (2012) · Cell Reports · doi:10.1016/j.celrep.2011.11.004 · Cited by 131 · see citing works

Observations on the ultrastructure of the choanoflagellate Codosiga botrytis (Ehr.) saville-kent with special reference to the flagellar apparatus

Hibberd, D. J. (1975) · Journal of Cell Science · doi:10.1242/jcs.17.1.191 · Cited by 125 · see citing works

Flagellates

Leadbeater, B. S. C., & Green, J. C. (2000) · doi:10.1201/9781482268225 · Cited by 121 · see citing works

Androglobin: A Chimeric Globin in Metazoans That Is Preferentially Expressed in Mammalian Testes

Hoogewijs, D., Ebner, B., Germani, F., Hoffmann, F. G., Fabrizius, A., Moens, L. J., Burmester, T., Dewilde, S., Storz, J. F., Vinogradov, S. N., et al. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr246 · Cited by 121 · see citing works

Genomic Survey of Premetazoans Shows Deep Conservation of Cytoplasmic Tyrosine Kinases and Multiple Radiations of Receptor Tyrosine Kinases

Suga, H., Dacre, M., de Mendoza, A., Shalchian‐Tabrizi, K., Manning, G., & Ruiz‐Trillo, I. (2012) · Science Signaling · doi:10.1126/scisignal.2002733 · Cited by 121 · see citing works

Epithelia and integration in sponges

Leys, S. P., Nichols, S., & ADAMS, E. D. M. (2009) · Integrative and Comparative Biology · doi:10.1093/icb/icp038 · Cited by 120 · see citing works

Die Kalkschwämme. Eine Monographie ...

Haeckel, E. (1872) · G. Reimer eBooks · doi:10.5962/bhl.title.11323 · Cited by 119 · see citing works

Life-history and ultrastructure of a new marine species of Proterospongia (Choanoflagellida)

Leadbeater, B. S. C. (1983) · Journal of the Marine Biological Association of the United Kingdom · doi:10.1017/s0025315400049857 · Cited by 118 · see citing works

Genomic insights into Wnt signaling in an early diverging metazoan, the ctenophore Mnemiopsis leidyi

Pang, K., Ryan, J. F., Program, N. C. S., Mullikin, J. C., Baxevanis, A. D., & Martindale, M. Q. (2010) · EvoDevo · doi:10.1186/2041-9139-1-10 · Cited by 115 · see citing works

A Search for the Origins of Animals and Fungi: Comparing and Combining Molecular Data

Baldauf, S. L. (1999) · The American Naturalist · doi:10.1086/303292 · Cited by 114 · see citing works

Phylogenetic analysis of the Hsp70 sequences reveals the monophyly of Metazoa and specific phylogenetic relationships between animals and fungi

Borchiellini, C., Boury‐Esnault, N., Vacelet, J., & Parco, Y. L. (1998) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a025968 · Cited by 113 · see citing works

Rangeomorphs, Thectardis (Porifera?) and dissolved organic carbon in the Ediacaran oceans: Rangeomorphs, Thectardis and DOC

SPERLING, E. A., PETERSON, K. J., & LAFLAMME, M. (2011) · Geobiology · doi:10.1111/j.1472-4669.2010.00259.x · Cited by 112 · see citing works

Origin of animal epithelia: insights from the sponge genome

Fahey, B., & Degnan, B. M. (2010) · Evolution &amp; Development · doi:10.1111/j.1525-142x.2010.00445.x · Cited by 109 · see citing works

Functional development of Src tyrosine kinases during evolution from a unicellular ancestor to multicellular animals

Segawa, Y., Suga, H., Iwabe, N., Oneyama, C., Akagi, T., Miyata, T., & Okada, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600021103 · Cited by 108 · see citing works

Epithelia, an Evolutionary Novelty of Metazoans

Leys, S. P., & Riesgo, A. (2011) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21442 · Cited by 107 · see citing works

Origin of metazoan adhesion molecules and adhesion receptors as deduced from cDNA analyses in the marine sponge Geodia cydonium : a review

Müller, W. E. G. (1997) · Cell and Tissue Research · doi:10.1007/s004410050885 · Cited by 104 · see citing works

The telomere repeat motif of basal Metazoa

Traut, W., Szczepanowski, M., Zrzavá, M., Opitz, C., Marec, F., & Zrzavý, J. (2007) · Chromosome Research · doi:10.1007/s10577-007-1132-3 · Cited by 104 · see citing works

Development of ichthyosporeans sheds light on the origin of metazoan multicellularity

Suga, H., & Ruiz‐Trillo, I. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.01.009 · Cited by 102 · see citing works

Regulatory Factor X (RFX)-mediated transcriptional rewiring of ciliary genes in animals

Piasecki, B. P., Burghoorn, J., & Swoboda, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914241107 · Cited by 100 · see citing works

Evolution of the MAGUK protein gene family in premetazoan lineages

de Mendoza, A., Suga, H., & Ruiz‐Trillo, I. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-93 · Cited by 100 · see citing works

Embryogenesis and larval differentiation in sponges

Leys, S. P., & Ereskovsky, A. V. (2006) · Canadian Journal of Zoology · doi:10.1139/z05-170 · Cited by 100 · see citing works

The SH2 Domain–Containing Proteins in 21 Species Establish the Provenance and Scope of Phosphotyrosine Signaling in Eukaryotes

Liu, B. A., Shah, E. E., Jablonowski, K. D., Stergachis, A. B., Engelmann, B. W., & Nash, P. (2011) · Science Signaling · doi:10.1126/scisignal.2002105 · Cited by 99 · see citing works

A talin homologue of Dictyostelium rapidly assembles at the leading edge of cells in response to chemoattractant.

Kreitmeier, M., Gerisch, G., Heizer, C., & Müller‐Taubenberger, A. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.1.179 · Cited by 98 · see citing works

THE CAMBRIAN EXPLOSION: ANIMALS OR FOSSILS?

Peterson, K. J. (2012) · 2012 GSA Annual Meeting in Charlotte · Cited by 98 · see citing works

The first animals: ca. 760-million-year-old sponge-like fossils from Namibia

Brain, C. K. ‘., Prave, A. R., Hoffmann, K.-H., Fallick, A. E., Botha, A., Herd, D. A., Sturrock, C. J., Young, I. M., Condon, D. J., & Allison, S. G. (2012) · South African Journal of Science · doi:10.4102/sajs.v108i1/2.658 · Cited by 96 · see citing works

The stem cell system in demosponges: Insights into the origin of somatic stem cells

Funayama, N. (2010) · Development, Growth &amp; Differentiation · doi:10.1111/j.1440-169x.2009.01162.x · Cited by 95 · see citing works

The genome of the sponge Amphimedon queenslandica provides new perspectives into the origin of Toll‐like and interleukin 1 receptor pathways

Gauthier, M. E. A., Pasquier, L. D., & Degnan, B. M. (2010) · Evolution & Development · doi:10.1111/j.1525-142x.2010.00436.x · Cited by 94 · see citing works

Unicellular Ca2+ Signaling 'Toolkit' at the Origin of Metazoa

Cai, X. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn077 · Cited by 93 · see citing works

Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes

Kawahara, T., & Lambeth, J. D. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-178 · Cited by 92 · see citing works

The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human Members

Almén, M. S., Bringeland, N., Fredriksson, R., & Schiöth, H. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031961 · Cited by 92 · see citing works

WNT/β-Catenin Signalling and Epithelial Patterning in the Homoscleromorph Sponge Oscarella

Lapébie, P., Gazave, E., Ereskovsky, A. V., Derelle, R., Bézac, C., Renard, E., Houliston, E., & Borchiellini, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005823 · Cited by 91 · see citing works

Phylogenetic Analysis of the Teneurins: Conserved Features and Premetazoan Ancestry

Tucker, R. P., Beckmann, J., Leachman, N. T., Schöler, J., & Chiquet‐Ehrismann, R. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr271 · Cited by 91 · see citing works

Evolutionary relationships of Metazoa within the eukaryotes based on molecular data from Porifera

Schütze, J., Krasko, A., Custódio, M. R., Efremova, S. M., Müller, I. M., & Müller, W. E. G. (1999) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1999.0605 · Cited by 86 · see citing works

Receptor kinase signalling in plants and animals: distinct molecular systems with mechanistic similarities

Cock, J. M., Vanoosthuyse, V., & Gaude, T. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00305-8 · Cited by 85 · see citing works

Signaling Properties of a Non-metazoan Src Kinase and the Evolutionary History of Src Negative Regulation

Li, W., Young, S. L., King, N., & Miller, W. T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800002200 · Cited by 79 · see citing works

The backbone of the post-synaptic density originated in a unicellular ancestor of choanoflagellates and metazoans

Alié, A., & Manuel, M. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-34 · Cited by 79 · see citing works

Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis

Burkhardt, P., Stegmann, C. M., Cooper, B. H., Kloepper, T. H., Imig, C., Varoqueaux, F., Wahl, M. C., & Fasshauer, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106189108 · Cited by 77 · see citing works

Organising cells into tissues: new roles for cell adhesion molecules in planar cell polarity

Saburi, S., & McNeill, H. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.08.011 · Cited by 75 · see citing works

Hsp70 sequences indicate that choanoflagellates are closely related to animals

Snell, E. A., Furlong, R. F., & Holland, P. W. H. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00275-5 · Cited by 73 · see citing works

Demosponge and Sea Anemone Fibrillar Collagen Diversity Reveals the Early Emergence of A/C Clades and the Maintenance of the Modular Structure of Type V/XI Collagens from Sponge to Human

Exposito, J., Larroux, C., Cluzel, C., Valcourt, U., Lethias, C., & Degnan, B. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804573200 · Cited by 71 · see citing works

Memoirs: The Gastraea-Theory, the Phylogenetic Classification of the Animal Kingdom and the Homology of the Germ-Lamellæ

Haeckel, E. (1874) · Journal of Cell Science · doi:10.1242/jcs.s2-14.54.142 · Cited by 70 · see citing works

Evolution of the holozoan ribosome biogenesis regulon

Brown, S. J., Cole, M. D., & Erives, A. J. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-442 · Cited by 70 · see citing works

A holistic phylogeny of the coronin gene family reveals an ancient origin of the tandem-coronin, defines a new subfamily, and predicts protein function

Eckert, C., Hammesfahr, B., & Kollmar, M. (2011) · BMC Evolutionary Biology · doi:10.1186/1471-2148-11-268 · Cited by 68 · see citing works

Multicellularity arose several times in the evolution of eukaryotes (Response to DOI 10.1002/bies.201100187)

Parfrey, L. W., & Lahr, D. J. G. (2013) · BioEssays · doi:10.1002/bies.201200143 · Cited by 66 · see citing works

Premetazoan Ancestry of the Myc–Max Network

Young, S. L., Diolaiti, D., Conacci‐Sorrell, M., Ruiz‐Trillo, I., Eisenman, R. N., & King, N. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr132 · Cited by 65 · see citing works

Tyrosine kinase signaling and the emergence of multicellularity

Miller, W. T. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.03.009 · Cited by 65 · see citing works

Convergent evolution of RFX transcription factors and ciliary genes predated the origin of metazoans

Chu, J. S., Baillie, D. L., & Chen, N. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-130 · Cited by 63 · see citing works

Early diversification and complex evolutionary history of the p53 tumor suppressor gene family

Nedelcu, A. M., & Tan, C. A. (2007) · Development Genes and Evolution · doi:10.1007/s00427-007-0185-9 · Cited by 63 · see citing works

An unusual choanoflagellate protein released by Hedgehog autocatalytic processing

Snell, E. A., Brooke, N. M., Taylor, W. R., Casañe, D., Philippe, H., & Holland, P. W. H. (2005) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2005.3263 · Cited by 63 · see citing works

Origin and Evolution of Laminin Gene Family Diversity

Fahey, B., & Degnan, B. M. (2012) · Molecular Biology and Evolution · doi:10.1093/molbev/mss060 · Cited by 61 · see citing works

Gastrulation in Calcareous Sponges: In Search of Haeckel's Gastraea

Leys, S. P. (2005) · Integrative and Comparative Biology · doi:10.1093/icb/45.2.342 · Cited by 57 · see citing works

An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity

Dickinson, D. J., Nelson, W. J., & Weis, W. I. (2012) · BioEssays · doi:10.1002/bies.201100187 · Cited by 54 · see citing works

Sponge Development and Antiquity of Animal Pattern Formation

Degnan, B. M. (2005) · Integrative and Comparative Biology · doi:10.1093/icb/45.2.335 · Cited by 54 · see citing works

XXXIII.—On the Spongiæ ciliatæ as Infusoria flagellata; or observations on the structure, animality, and relationship of Leucosolenia botryoides, bowerbank

James‐Clark, H. (1868) · Annals and Magazine of Natural History · doi:10.1080/00222936808695688 · Cited by 53 · see citing works

The kinome of Phytophthora infestans reveals oomycete-specific innovations and links to other taxonomic groups

Judelson, H. S., & Ah‐Fong, A. M. V. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-700 · Cited by 53 · see citing works

A cooperative model for receptor recognition and cell adhesion: evidence from the molecular packing in the 1.6-A crystal structure of the pheromone Er-1 from the ciliated protozoan Euplotes raikovi.

Weiss, M. S., Anderson, D. H., Raffioni, S., Bradshaw, R. A., Ortenzi, C., Luporini, P., & Eisenberg, D. S. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10172 · Cited by 52 · see citing works

Evolution of the 2′-5′-Oligoadenylate Synthetase Family in Eukaryotes and Bacteria

Kjær, K. H., Poulsen, J. B., Reintamm, T., Saby, E., Martensen, P. M., Kelve, M., & Justesen, J. (2009) · Journal of Molecular Evolution · doi:10.1007/s00239-009-9299-1 · Cited by 52 · see citing works

Comparative Genomics of Phylogenetically Diverse Unicellular Eukaryotes Provide New Insights into the Genetic Basis for the Evolution of the Programmed Cell Death Machinery

Nedelcu, A. M. (2009) · Journal of Molecular Evolution · doi:10.1007/s00239-009-9201-1 · Cited by 51 · see citing works

Sponge homologs of vertebrate protein tyrosine kinases and frequent domain shufflings in the early evolution of animals before the parazoan–eumetazoan split

Suga, H., Katoh, K., & Miyata, T. (2001) · Gene · doi:10.1016/s0378-1119(01)00784-3 · Cited by 49 · see citing works

XXII.—On the Spongiæ ciliatæ as Infusoria flagellata; or observations on the structure, animality, and relationship of Leucosolenia botryoides, Bowerbank

James‐Clark, H. (1868) · Annals and Magazine of Natural History · doi:10.1080/00222936808695657 · Cited by 42 · see citing works

NK homeobox genes with choanocyte-specific expression in homoscleromorph sponges

Gazave, E., Lapébie, P., Renard, E., Bézac, C., Boury-Esnault, N., Vacelet, J., Pérez, T., Manuel, M., & Borchiellini, C. (2008) · Development Genes and Evolution · doi:10.1007/s00427-008-0242-z · Cited by 42 · see citing works

Mitochondrial carrier homolog 2 (MTCH2): The recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis

Robinson, A. J., Kunji, E. R. S., & Gross, A. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.01.026 · Cited by 42 · see citing works

Molecular-phylogenetic, structural and biochemical features of a cold-adapted, marine ichthyosporean near the animal-fungal divergence, described from in vitro cultures

Jøstensen, J.-P., Sperstad, S. V., Johansen, S., & Landfald, B. (2002) · European Journal of Protistology · doi:10.1078/0932-4739-00855 · Cited by 38 · see citing works

Involvement of a 40-kDa Glycoprotein in Food Recognition, Prey Capture, and Induction of Phagocytosis in the Protozoon Actinophrys sol

Sakaguchi, M., Murakami, H., & Suzaki, T. (2001) · Protist · doi:10.1078/1434-4610-00041 · Cited by 37 · see citing works

Ultrastructure of the collar of the choanoflagellate Codonosiga botrytis (Ehrenb.)

Fjerdingstad, E. J. (1961) · Cell and Tissue Research · doi:10.1007/bf00340451 · Cited by 36 · see citing works

Developmental expression of COE across the Metazoa supports a conserved role in neuronal cell-type specification and mesodermal development

Jackson, D. J., Meyer, N. P., Seaver, E. C., Pang, K., McDougall, C., Moy, V. N., Gordon, K. L., Degnan, B. M., Martindale, M. Q., Burke, R. D., et al. (2010) · Development Genes and Evolution · doi:10.1007/s00427-010-0343-3 · Cited by 36 · see citing works

Neuroglobins, Pivotal Proteins Associated with Emerging Neural Systems and Precursors of Metazoan Globin Diversity

Lechauve, C., Jager, M., Laguerre, L., Kiger, L., Correc, G., Leroux, C., Vinogradov, S. N., Czjzek, M., Marden, M. C., & Bailly, X. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.407601 · Cited by 36 · see citing works

Nme Gene Family Evolutionary History Reveals Pre-Metazoan Origins and High Conservation between Humans and the Sea Anemone, Nematostella vectensis

Desvignes, T., Pontarotti, P., & Bobe, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015506 · Cited by 35 · see citing works

Phylogeny of Tec Family Kinases: Identification of a Premetazoan Origin of Btk, Bmx, Itk, Tec, Txk, and the Btk Regulator SH3BP5

Ortutay, C., Nore, B. F., Vihinen, M., & Smith, C. I. E. (2008) · Advances in genetics · doi:10.1016/s0065-2660(08)00803-1 · Cited by 34 · see citing works

Early Neoproterozoic origin of the metazoan clade recorded in carbonate rock texture

Neuweiler, F., Turner, E. C., & Burdige, D. J. (2009) · Geology · doi:10.1130/g25621a.1 · Cited by 34 · see citing works

Ancient origin of animal U-box ubiquitin ligases

Marı́n, I. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-331 · Cited by 31 · see citing works

Phylogeny and evolution of Rab7 and Rab9 proteins

Mackiewicz, P., & Wyroba, E. (2009) · BMC Evolutionary Biology · doi:10.1186/1471-2148-9-101 · Cited by 31 · see citing works

SELF-RECOGNITION AS THE ORIGINAL FUNCTION OF AN AMOEBAN DEFENSE-INDUCING KAIROMONE

Kusch, J. (1999) · Ecology · doi:10.1890/0012-9658(1999)080[0715:sratof]2.0.co;2 · Cited by 30 · see citing works

Cysteine Proteases and Cell Differentiation: Excystment of the Ciliated Protist Sterkiella histriomuscorum

Villalobo, E., Moch, C., Fryd-Versavel, G., Fleury‐Aubusson, A., & Morin, L. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.6.1234-1245.2003 · Cited by 30 · see citing works

Multiple Independent Fusions of Glucose-6-Phosphate Dehydrogenase with Enzymes in the Pentose Phosphate Pathway

Stover, N. A., Dixon, T. A., & Cavalcanti, A. R. O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022269 · Cited by 29 · see citing works

Ancient divergence of animal protein tyrosine kinase genes demonstrated by a gene family tree including choanoflagellate genes

Suga, H., Sasaki, G., Kuma, K.-I., Nishiyori, H., Hirose, N., Su, Z.-H., Iwabe, N., & Miyata, T. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.02.002 · Cited by 29 · see citing works

Early Neoproterozoic origin of the metazoan clade recorded in carbonate rock texture: REPLY

Neuweiler, F., Turner, E. C., & Burdige, D. J. (2009) · Geology · doi:10.1130/g30484y.1 · Cited by 29 · see citing works

The RJL family of small GTPases is an ancient eukaryotic invention probably functionally associated with the flagellar apparatus

Eliáš, M., & Archibald, J. M. (2009) · Gene · doi:10.1016/j.gene.2009.04.011 · Cited by 28 · see citing works

Evolution of the spectrin-based membrane skeleton

Baines, A. J. (2010) · Transfusion Clinique et Biologique · doi:10.1016/j.tracli.2010.06.008 · Cited by 26 · see citing works

Genomic, phylogenetic, and cell biological insights into metazoan origins

Nichols, S. A., Dayel, M. J., & King, N. (2009) · Animal Evolution · doi:10.1093/acprof:oso/9780199549429.003.0003 · Cited by 24 · see citing works

Cyst Formation in a Freshwater Strain of the Choanoflagellate Desmarella moniliformis Kent

Leadbeater, B. S. C., & Karpov, S. A. (2000) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2000.tb00071.x · Cited by 22 · see citing works

Functional prediction and physiological characterization of a novel short trans-membrane protein 1 as a subunit of mitochondrial respiratory complexes

Zhang, D., Xi, Y., Coccimiglio, M. L., Mennigen, J. A., Jonz, M. G., Ekker, M., & Trudeau, V. L. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00079.2012 · Cited by 22 · see citing works

Evolutionary genomics reveals the premetazoan origin of opposite gating polarity in animal-type voltage-gated ion channels

Cai, X. (2012) · Genomics · doi:10.1016/j.ygeno.2012.01.007 · Cited by 21 · see citing works

Citric acid cycle and the origin of MARS

Eswarappa, S. M., & Fox, P. L. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.01.005 · Cited by 21 · see citing works

Lack of Csk-Mediated Negative Regulation in a Unicellular Src Kinase

Schultheiss, K. P., Suga, H., Ruiz‐Trillo, I., & Miller, W. T. (2012) · Biochemistry · doi:10.1021/bi300965h · Cited by 20 · see citing works

The Cell Type-Specific Signal Proteins (Pheromones) of Protozoan Ciliates

Luporini, P., Vallesi, A., Alimenti, C., & Ortenzi, C. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206777947452 · Cited by 20 · see citing works

Evolutionary Conservation of the Ribosomal Biogenesis Factor Rbm19/Mrd1: Implications for Function

Kallberg, Y., Segerstolpe, Å., Lackmann, F., Persson, B., & Wieslander, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043786 · Cited by 14 · see citing works

Evolution of sodium channels and the new view of early nervous system evolution

Liebeskind, B. J. (2011) · Communicative & Integrative Biology · doi:10.4161/cib.17069 · Cited by 12 · see citing works

Evidence for Convergent Evolution in the Signaling Properties of a Choanoflagellate Tyrosine Kinase

Li, W., Scarlata, S., & Miller, W. T. (2009) · Biochemistry · doi:10.1021/bi9000672 · Cited by 12 · see citing works

PTB Domain-Directed Substrate Targeting in a Tyrosine Kinase from the Unicellular Choanoflagellate Monosiga brevicollis

Prieto-Echagüe, V., Chan, P. M., Craddock, B. P., Manser, E. J., & Miller, W. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019296 · Cited by 10 · see citing works

Functional transition of Pak proto-oncogene during early evolution of metazoans

Watari, A., Iwabe, N., Masuda, H., & Okada, M. (2010) · Oncogene · doi:10.1038/onc.2010.148 · Cited by 8 · see citing works

Arginine kinase isoforms in the closest protozoan relative of metazoans

Hoffman, G. G., & Ellington, W. R. (2011) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2011.02.004 · Cited by 7 · see citing works

Metazoan-like signaling in a unicellular receptor tyrosine kinase

Schultheiss, K. P., Craddock, B. P., Tong, M., Seeliger, M. A., & Miller, W. T. (2013) · BMC Biochemistry · doi:10.1186/1471-2091-14-4 · Cited by 6 · see citing works

I.—A description of two new Calcispongiæ, to which is added confirmation of Prof. James-Clark's discovery of the true form of the sponge-cell (animal), and an account of the polype-like pore-area of Cliona corallinoides contrasted with Prof. E. Häckel's view on the relationship of the sponges to the corals

Carter, H. J. (1871) · Annals and Magazine of Natural History · doi:10.1080/00222937108696422 · Cited by 6 · see citing works

XXVII.—On the Calcispongiæ, their position in the animal kingdom, and their relation to the theory of descendence

Häckel, E. (1873) · Annals and Magazine of Natural History · doi:10.1080/00222937308696810 · Cited by 5 · see citing works

Nature of Cancer Explored from the Perspective of the Functional Evolution of Proto-oncogenes

Watari, A. (2012) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.12-00204 · Cited by 3 · see citing works

The Origin of Animal Multicellularity and Cell Differentiation

(2017) · doi:10.1016/j.devcel.2017.09.016 · Cited by 419 · see citing works

A Structural Perspective on the Regulation of the Epidermal Growth Factor Receptor

Kovács, E., Zorn, J. A., Huang, Y., Barros, T. F., & Kuriyan, J. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034402 · Cited by 371 · see citing works

The origin of Metazoa: a unicellular perspective

Sebé-Pedrós, A., Degnan, B. M., & Ruiz-Trillo, I. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.21 · Cited by 332 · see citing works

Gene family innovation, conservation and loss on the animal stem lineage

(2018) · doi:10.7554/elife.34226 · Cited by 226 · see citing works

The triple helix of collagens – an ancient protein structure that enabled animal multicellularity and tissue evolution

Fidler, A. L., Boudko, S. P., Rokas, A., & Hudson, B. G. (2018) · Journal of Cell Science · doi:10.1242/jcs.203950 · Cited by 228 · see citing works

Interorgan Communication Pathways in Physiology: Focus on Drosophila

Droujinine, I. A., & Perrimon, N. (2016) · Annual Review of Genetics · doi:10.1146/annurev-genet-121415-122024 · Cited by 205 · see citing works

Light-regulated collective contractility in a multicellular choanoflagellate

(2019) · doi:10.1126/science.aay2346 · Cited by 169 · see citing works

Dynamics of genomic innovation in the unicellular ancestry of animals

Grau-Bové, X., Torruella, G., Donachie, S. P., Suga, H., Leonard, G., Richards, T., & Ruiz-Trillo, I. (2017) · eLife · doi:10.7554/elife.26036 · Cited by 166 · see citing works

TALEN and CRISPR/Cas9-mediated genome editing in the early-branching metazoan Nematostella vectensis

Ikmi, A., McKinney, S. A., Delventhal, K. M., & Gibson, M. C. (2014) · Nature Communications · doi:10.1038/ncomms6486 · Cited by 165 · see citing works

The origin of animals: an ancestral reconstruction of the unicellular-to-multicellular transition

Ros-Rocher, N., Pérez-Posada, A., Leger, M. M., & Ruiz‐Trillo, I. (2021) · Open Biology · doi:10.1098/rsob.200359 · Cited by 160 · see citing works

Using ancient protein kinases to unravel a modern cancer drug’s mechanism

Wilson, C., Agafonov, R. V., Hoemberger, M., Kutter, S., Zorba, A., Halpin, J. C., Buosi, V., Otten, R., Waterman, D. P., Theobald, D. L., et al. (2015) · Science · doi:10.1126/science.aaa1823 · Cited by 155 · see citing works

Embracing Uncertainty in Reconstructing Early Animal Evolution

King, N., & Rokas, A. (2017) · Current Biology · doi:10.1016/j.cub.2017.08.054 · Cited by 144 · see citing works

Complex multicellularity in fungi: evolutionary convergence, single origin, or both?

Nagy, L. G., Kovács, G. M., & Krizsán, K. (2018) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12418 · Cited by 140 · see citing works

The origin of animal body plans: a view from fossil evidence and the regulatory genome

Erwin, D. H. (2020) · Development · doi:10.1242/dev.182899 · Cited by 133 · see citing works

Oxygen and animal evolution: Did a rise of atmospheric oxygen "trigger" the origin of animals?

Mills, D. B., & Canfield, D. E. (2014) · BioEssays · doi:10.1002/bies.201400101 · Cited by 138 · see citing works

Bacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates

Woznica, A., Cantley, A. M., Beemelmanns, C., Freinkman, E., Clardy, J., & King, N. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605015113 · Cited by 136 · see citing works

Reconstruction of the ancestral metazoan genome reveals an increase in genomic novelty

Paps, J., & Holland, P. W. H. (2018) · Nature Communications · doi:10.1038/s41467-018-04136-5 · Cited by 135 · see citing works

Tracing animal genomic evolution with the chromosomal-level assembly of the freshwater sponge Ephydatia muelleri

Kenny, N. J., Francis, W. R., Rivera-Vicéns, R. E., Juravel, K., de Mendoza, A., Díez-Vives, C., Lister, R., Bezares-Calderón, L. A., Grombacher, L., Roller, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17397-w · Cited by 129 · see citing works

Diversity as opportunity: Insights from 600 million years of AHR evolution

Hahn, M. E., Karchner, S. I., & Merson, R. R. (2017) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2017.02.003 · Cited by 134 · see citing works

Deconstruction of the Ras switching cycle through saturation mutagenesis

Bandaru, P., Shah, N. H., Bhattacharyya, M., Barton, J. P., Kondo, Y., Cofsky, J. C., Gee, C. L., Chakraborty, A. K., Kortemme, T., Ranganathan, R., et al. (2017) · eLife · doi:10.7554/elife.27810 · Cited by 117 · see citing works

Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II

Bhattacharyya, M., Stratton, M. M., Going, C. C., McSpadden, E. D., Huang, Y., Susa, A. C., Elleman, A., Cao, Y. M., Pappireddi, N., Burkhardt, P., et al. (2016) · eLife · doi:10.7554/elife.13405 · Cited by 112 · see citing works

Notch: A multi-functional integrating system of microenvironmental signals

LaFoya, B., Munroe, J. A., Mia, M. M., Detweiler, M. A., Crow, J. J., Wood, T., Roth, S., Sharma, B., & Albig, A. R. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.08.023 · Cited by 102 · see citing works

The Future of Cell Biology: Emerging Model Organisms

Goldstein, B., & King, N. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.08.005 · Cited by 97 · see citing works

Structural Insights into the Regulation of Ca²⁺/Calmodulin-Dependent Protein Kinase II (CaMKII)

Bhattacharyya, M., Karandur, D., & Kuriyan, J. (2020) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a035147 · Cited by 95 · see citing works

The architecture of cell differentiation in choanoflagellates and sponge choanocytes

Laundon, D., Larson, B. T., McDonald, K., King, N., & Burkhardt, P. (2019) · PLOS Biology · doi:10.1371/journal.pbio.3000226 · Cited by 93 · see citing works

The rosetteless gene controls development in the choanoflagellate S. rosetta

Levin, T. C., Greaney, A. J., Wetzel, L. A., & King, N. (2014) · eLife · doi:10.7554/elife.04070 · Cited by 93 · see citing works

Recurrent horizontal transfer of arsenite methyltransferase genes facilitated adaptation of life to arsenic

Chen, S., Sun, G., Rosen, B. P., Zhang, S., Deng, Y., Zhu, B., Rensing, C., & Zhu, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-08313-2 · Cited by 93 · see citing works

The placenta as a model for understanding the origin and evolution of vertebrate organs

Griffith, O. W., & Wagner, G. P. (2017) · Nature Ecology & Evolution · doi:10.1038/s41559-017-0072 · Cited by 91 · see citing works

The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases

Shah, N. H., Amacher, J. F., Nocka, L. M., & Kuriyan, J. (2018) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2018.1495173 · Cited by 91 · see citing works

Phylogenetic evidence for the modular evolution of metazoan signalling pathways

Babonis, L. S., & Martindale, M. Q. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0477 · Cited by 86 · see citing works

Injury-induced immune responses in Hydra

Wenger, Y., Buzgariu, W. C., Reiter, S., & Galliot, B. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.06.004 · Cited by 89 · see citing works

The role of G protein-coupled receptors in the early evolution of neurotransmission and the nervous system

Krishnan, A., & Schiöth, H. B. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.110312 · Cited by 81 · see citing works

Early animal evolution: a morphologist's view

Nielsen, C. (2019) · Royal Society Open Science · doi:10.1098/rsos.190638 · Cited by 77 · see citing works

Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity

Gaiti, F., Jindrich, K., Fernández-Valverde, S. L., Roper, K. E., Degnan, B. M., & Tanurdžić, M. (2017) · eLife · doi:10.7554/elife.22194 · Cited by 84 · see citing works

Green Algal Models for Multicellularity

Umen, J., & Herron, M. D. (2021) · Annual Review of Genetics · doi:10.1146/annurev-genet-032321-091533 · Cited by 78 · see citing works

Convergence of ion channel genome content in early animal evolution

Liebeskind, B. J., Hillis, D. M., & Zakon, H. H. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501195112 · Cited by 76 · see citing works

Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals

de Mendoza, A., Suga, H., Permanyer, J., Irimia, M., & Ruiz‐Trillo, I. (2015) · eLife · doi:10.7554/elife.08904 · Cited by 67 · see citing works

The Evolution of the Hallmarks of Aging

Lemoine, M. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.693071 · Cited by 69 · see citing works

Insights into the early evolution of animal calcium signaling machinery: A unicellular point of view

Cai, X., Wang, X., Patel, S., & Clapham, D. E. (2014) · Cell Calcium · doi:10.1016/j.ceca.2014.11.007 · Cited by 67 · see citing works

Complex Homology and the Evolution of Nervous Systems

Liebeskind, B. J., Hillis, D. M., Zakon, H. H., & Hofmann, H. A. (2015) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2015.12.005 · Cited by 67 · see citing works

Bacterial Influences on Animal OriginsPreprint

Alegado, R. ʻ., & King, N. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016162 · Cited by 67 · see citing works

Choanoflagellate models — Monosiga brevicollis and Salpingoeca rosetta

Hoffmeyer, T. T., & Burkhardt, P. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.05.016 · Cited by 66 · see citing works

Ephrin-Eph signaling in embryonic tissue separation

Fagotto, F., Winklbauer, R., & Rohani, N. (2014) · Cell Adhesion & Migration · doi:10.4161/19336918.2014.970028 · Cited by 66 · see citing works

Exploring the evolutionary history of centrosomes

Azimzadeh, J. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0453 · Cited by 66 · see citing works

A six-gene phylogeny provides new insights into choanoflagellate evolution

Carr, M., Richter, D. J., Fozouni, P., Smith, T. J., Jeuck, A., Leadbeater, B. S. C., & Nitsche, F. (2016) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2016.10.011 · Cited by 64 · see citing works

Four domains: The fundamental unicell and Post-Darwinian Cognition-Based Evolution

Miller, W. B., & Torday, J. S. (2018) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2018.04.006 · Cited by 64 · see citing works

The many faces of cell adhesion during Drosophila muscle development

Maartens, A. P., & Brown, N. H. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2014.12.038 · Cited by 63 · see citing works

Evolution of an ancient protein function involved in organized multicellularity in animals

Anderson, D. P., Whitney, D. S., Hanson-Smith, V., Woznica, A., Campodonico-Burnett, W., Volkman, B. F., King, N., Thornton, J. W., & Prehoda, K. E. (2016) · eLife · doi:10.7554/elife.10147 · Cited by 63 · see citing works

Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen

Shah, N. H., Löbel, M., Weiss, A., & Kuriyan, J. (2018) · eLife · doi:10.7554/elife.35190 · Cited by 63 · see citing works

The origin and evolution of synaptic proteins – choanoflagellates lead the way

Burkhardt, P. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.110247 · Cited by 59 · see citing works

Origin and evolution of the metazoan non-coding regulatory genome

Gaiti, F., Calcino, A., Tanurdžić, M., & Degnan, B. M. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.11.013 · Cited by 58 · see citing works

Evolutionary origin of synapses and neurons – Bridging the gap

Burkhardt, P., & Sprecher, S. G. (2017) · BioEssays · doi:10.1002/bies.201700024 · Cited by 60 · see citing works

Wnt signaling and polarity in freshwater sponges

Windsor-Reid, P., Matveev, E., McClymont, A., Posfai, D., Hill, A. L., & Leys, S. P. (2018) · BMC Evolutionary Biology · doi:10.1186/s12862-018-1118-0 · Cited by 57 · see citing works

Progress in ciliary ion channel physiology

Pablo, J. L., DeCaen, P. G., & Clapham, D. E. (2016) · The Journal of General Physiology · doi:10.1085/jgp.201611696 · Cited by 57 · see citing works

Unicellular origin of the animal microRNA machinery

Bråte, J., Neumann, R. S., Fromm, B., Haraldsen, A. A. B., Tarver, J. E., Suga, H., Donoghue, P. C. J., Peterson, K. J., Ruiz-Trillo, I., Grini, P. E., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.08.018 · Cited by 53 · see citing works

Reconstruction of protein domain evolution using single-cell amplified genomes of uncultured choanoflagellates sheds light on the origin of animals

López‐Escardó, D., Grau‐Bové, X., Guillaumet-Adkins, A., Gut, M., Sieracki, M. E., & Ruiz‐Trillo, I. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0088 · Cited by 54 · see citing works

Conserved expression of vertebrate microvillar gene homologs in choanocytes of freshwater sponges

Peña, J. F., Alié, A., Richter, D. J., Wang, L., Funayama, N., & Nichols, S. (2016) · EvoDevo · doi:10.1186/s13227-016-0050-x · Cited by 54 · see citing works

Hierarchical complexity and the size limits of life

Heim, N. A., Payne, J. L., Finnegan, S., Knope, M. L., Kowalewski, M., Lyons, S. K., McShea, D. W., Novack‐Gottshall, P. M., Smith, F. A., & Wang, S. C. (2017) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2017.1039 · Cited by 54 · see citing works

Understanding Haemonchus contortus Better Through Genomics and Transcriptomics

Gasser, R. B., Schwarz, E. M., Korhonen, P. K., & Young, N. D. (2016) · Advances in Parasitology/Advances in parasitology · doi:10.1016/bs.apar.2016.02.015 · Cited by 52 · see citing works

Molecular clocks and the early evolution of metazoan nervous systems

Wray, G. A. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0046 · Cited by 51 · see citing works

STING mediates immune responses in the closest living relatives of animals

Woznica, A., Kumar, A., Sturge, C. R., Xing, C., King, N., & Pfeiffer, J. K. (2021) · eLife · doi:10.7554/elife.70436 · Cited by 48 · see citing works

Getting Nervous: An Evolutionary Overhaul for Communication

Varoqueaux, F., & Fasshauer, D. (2017) · Annual Review of Genetics · doi:10.1146/annurev-genet-120116-024648 · Cited by 47 · see citing works

Evolution of Animal Neural Systems

Liebeskind, B. J., Hofmann, H. A., Hillis, D. M., & Zakon, H. H. (2017) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev-ecolsys-110316-023048 · Cited by 52 · see citing works

The Structure of an NDR/LATS Kinase–Mob Complex Reveals a Novel Kinase–Coactivator System and Substrate Docking Mechanism

Gógl, G., Schneider, K. D., Yeh, B. J., Nashida, A., Ba, A. N. N., Moses, A. M., Hetényi, C., Reményi, A., & Weiss, E. L. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002146 · Cited by 46 · see citing works

Anchors and Signals

Maartens, A. P., & Brown, N. H. (2015) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2014.11.020 · Cited by 44 · see citing works

Deep mutational analysis reveals functional trade-offs in the sequences of EGFR autophosphorylation sites

Cantor, A. J., Shah, N. H., & Kuriyan, J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803598115 · Cited by 46 · see citing works

Pre-metazoan origins and evolution of the cadherin adhesome

Murray, P. S., & Zaidel‐Bar, R. (2014) · Biology Open · doi:10.1242/bio.20149761 · Cited by 43 · see citing works

Transfection of Capsaspora owczarzaki , a close unicellular relative of animals

Parra-Acero, H., Ros-Rocher, N., Pérez-Posada, A., Kożyczkowska, A., Sánchez-Pons, N., Nakata, A., Suga, H., Najle, S. R., & Ruiz‐Trillo, I. (2018) · Development · doi:10.1242/dev.162107 · Cited by 42 · see citing works

The evolution of multicellularity and cancer: views and paradigms

Nedelcu, A. M. (2020) · Biochemical Society Transactions · doi:10.1042/bst20190992 · Cited by 44 · see citing works

The ventral epithelium of Trichoplax adhaerens deploys in distinct patterns cells that secrete digestive enzymes, mucus or diverse neuropeptides

Mayorova, T. D., Hammar, K. M., Winters, C. A., Reese, T. S., & Smith, C. L. (2019) · Biology Open · doi:10.1242/bio.045674 · Cited by 40 · see citing works

Animals in a bacterial world: opportunities for chemical ecology

Cantley, A. M., & Clardy, J. (2015) · Natural Product Reports · doi:10.1039/c4np00141a · Cited by 40 · see citing works

A trophic framework for animal origins

Mills, D. B., & Canfield, D. E. (2016) · Geobiology · doi:10.1111/gbi.12216 · Cited by 38 · see citing works

Synthesis of the Rosette-Inducing Factor RIF-1 and Analogs

Beemelmanns, C., Woznica, A., Alegado, R. ʻ., Cantley, A. M., King, N., & Clardy, J. (2014) · Journal of the American Chemical Society · doi:10.1021/ja5046692 · Cited by 38 · see citing works

The Origin of Metazoan Multicellularity: A Potential Microbial Black Swan Event

Ruiz-Trillo, I., Kin, K., & Casacuberta, E. (2023) · Annual Review of Microbiology · doi:10.1146/annurev-micro-032421-120023 · Cited by 36 · see citing works

The Cosmic Zoo: The (Near) Inevitability of the Evolution of Complex, Macroscopic Life

Bains, W., & Schulze‐Makuch, D. (2016) · Life · doi:10.3390/life6030025 · Cited by 35 · see citing works

The origins of developmental gene regulation

Arenas‐Mena, C. (2017) · Evolution & Development · doi:10.1111/ede.12217 · Cited by 35 · see citing works

Independent evolution of genomic characters during major metazoan transitions

Simakov, O., & Kawashima, T. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.11.012 · Cited by 35 · see citing works

Cell-Type Transcriptomes of the Multicellular Green AlgaVolvox carteriYield Insights into the Evolutionary Origins of Germ and Somatic Differentiation Programs

Matt, G. Y., & Umen, J. (2017) · G3 Genes Genomes Genetics · doi:10.1534/g3.117.300253 · Cited by 34 · see citing works

Cell–Cell Contact and Receptor Tyrosine Kinase SignalingPreprint

Chiasson-MacKenzie, C., & McClatchey, A. I. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a029215 · Cited by 34 · see citing works

Cellular Basis of Cognition in Evolution: From Protists and Fungi Up to Animals, Plants, and Root-Fungal Networks

Baluška, F., Miller, W. B., & Reber, A. S. (2023) · The MIT Press eBooks · doi:10.7551/mitpress/14642.003.0006 · Cited by 33 · see citing works

Sponges as models to study emergence of complex animals

Adamska, M. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.05.026 · Cited by 34 · see citing works

Histories of molecules: Reconciling the past

O’Malley, M. A. (2015) · Studies in History and Philosophy of Science Part A · doi:10.1016/j.shpsa.2015.09.002 · Cited by 33 · see citing works

The Emergence of the TardigradeHypsibius exemplarisas a Model SystemPreprint

Goldstein, B. (2018) · Cold Spring Harbor Protocols · doi:10.1101/pdb.emo102301 · Cited by 33 · see citing works

Experimental Evolution of Multicellular Complexity in Saccharomyces cerevisiae

Ratcliff, W. C., & Travisano, M. (2014) · BioScience · doi:10.1093/biosci/biu045 · Cited by 31 · see citing works

Origins of cancer: ain’t it just mature cells misbehaving?

Cho, C. J., Brown, J. W., & Mills, J. C. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00099-0 · Cited by 30 · see citing works

Effects of cell morphology and attachment to a surface on the hydrodynamic performance of unicellular choanoflagellates

Nguyen, H., Koehl, M. A. R., Oakes, C., Bustamante, G., & Fauci, L. (2019) · Journal of The Royal Society Interface · doi:10.1098/rsif.2018.0736 · Cited by 29 · see citing works

Selective factors in the evolution of multicellularity in choanoflagellates

Koehl, M. A. R. (2020) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.22941 · Cited by 29 · see citing works

Stable transfection in protist Corallochytrium limacisporum identifies novel cellular features among unicellular animals relatives

Kożyczkowska, A., Najle, S. R., Ocaña‐Pallarès, E., Aresté, C., Shabardina, V., Ara, P. S., Ruiz‐Trillo, I., & Casacuberta, E. (2021) · Current Biology · doi:10.1016/j.cub.2021.06.061 · Cited by 27 · see citing works

When the end modifies its means: the origins of novelty and the evolution of innovation

Moczek, A. P. (2022) · Biological Journal of the Linnean Society · doi:10.1093/biolinnean/blac061 · Cited by 26 · see citing works

Animal multicellularity and polarity without Wnt signaling

Schenkelaars, Q., Pratlong, M., Kodjabachian, L., Fierro‐Constaín, L., Vacelet, J., Bivic, A. L., Renard, E., & Borchiellini, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-15557-5 · Cited by 26 · see citing works

Novel Diversity of Deeply Branching Holomycota and Unicellular Holozoans Revealed by Metabarcoding in Middle Paraná River, Argentina

Arroyo, A. S., López‐Escardó, D., Kim, E., Ruiz‐Trillo, I., & Najle, S. R. (2018) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2018.00099 · Cited by 26 · see citing works

Cell polarity signalling at the birth of multicellularity: What can we learn from the first animals

Wright, B. A., Kvansakul, M., Schierwater, B., & Humbert, P. O. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1024489 · Cited by 25 · see citing works

Placozoan fiber cells: mediators of innate immunity and participants in wound healing

Mayorova, T. D., Hammar, K. M., Jung, J. H., Aronova, M. A., Zhang, G., Winters, C. A., Reese, T. S., & Smith, C. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-02735-9 · Cited by 26 · see citing works

Varied solutions to multicellularity: The biophysical and evolutionary consequences of diverse intercellular bonds

Day, T. C., Márquez-Zacarías, P., Bravo, P., Pokhrel, A. R., MacGillivray, K. A., Ratcliff, W. C., & Yunker, P. J. (2022) · Biophysics Reviews · doi:10.1063/5.0080845 · Cited by 27 · see citing works

Establishment of Transgenesis in the Demosponge Suberites domuncula

Revilla‐i‐Domingo, R., Schmidt, C., Zifko, C., & Raible, F. (2018) · Genetics · doi:10.1534/genetics.118.301121 · Cited by 25 · see citing works

The early animal radiation: insights from interpreting the Cambrian problematic fossils

Cong, P. (2023) · Frontiers in Earth Science · doi:10.3389/feart.2023.1120118 · Cited by 23 · see citing works

A possible billion-year-old holozoan with differentiated multicellularity

Strother, P. K., Brasier, M. D., Wacey, D., Timpe, L. C., Saunders, M., & Wellman, C. H. (2021) · Current Biology · doi:10.1016/j.cub.2021.03.051 · Cited by 23 · see citing works

Evolution of Functional Diversity in the Holozoan Tyrosine Kinome

Yeung, W., Kwon, A., Taujale, R., Bunn, C., Venkat, A., & Kannan, N. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab272 · Cited by 21 · see citing works

The Desmosome-Keratin Scaffold Integrates ErbB Family and Mechanical Signaling to Polarize Epidermal Structure and Function

Green, K. J., Niessen, C. M., Rübsam, M., White, B. E. P., & Broussard, J. A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.903696 · Cited by 23 · see citing works

Ancestral reconstruction of protein interaction networks

Liebeskind, B. J., Aldrich, R. W., & Marcotte, E. M. (2019) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007396 · Cited by 22 · see citing works

A Comparative Genomics Perspective on the Origin of Multicellularity and Early Animal Evolution

Srivastava, M. (2015) · Advances in marine genomics · doi:10.1007/978-94-017-9642-2_14 · Cited by 10 · see citing works

The origin of Metazoa: a unicellular perspective

Sebé-Pedrós, A., Degnan, B. M., & Ruiz-Trillo, I. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.21 · Cited by 332 · see citing works

Genomic, phylogenetic, and cell biological insights into metazoan origins

Nichols, S. A., Dayel, M. J., & King, N. (2009) · Animal Evolution · doi:10.1093/acprof:oso/9780199549429.003.0003 · Cited by 24 · see citing works

The Protistan Cellular and Genomic Roots of Animal Multicellularity

de Mendoza, A., & Sebé-Pedrós, A. (2019) · Fascinating life sciences · doi:10.1007/978-3-030-18202-1_2 · Cited by 1 · see citing works

Dynamics of genomic innovation in the unicellular ancestry of animals

Grau-Bové, X., Torruella, G., Donachie, S. P., Suga, H., Leonard, G., Richards, T., & Ruiz-Trillo, I. (2017) · eLife · doi:10.7554/elife.26036 · Cited by 166 · see citing works