The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
The orbitofrontal cortex and anxiety disorders
Abstract
This chapter reviews contemporary neurocircuitry models of anxiety disorders, with a focus on the role of the orbitofrontal cortex (OFC). In addition to human neuroimaging studies, findings from animal research are also considered, with emphasis on fear conditioning and extinction paradigms. The anatomical distinction between medial and lateral OFC is highlighted; medial OFC has been implicated in rewards and conditioned fear extinction recall, whereas reciprocally the lateral OFC has been implicated in evaluating punishers and mediating negative affects. As similarities and differences across the anxiety disorders are explored, the distinction is made between: 1) exaggerated ‘bottom-up’ amygdala responses; 2) failure of ‘top-down’ control by the medial OFC; and 3) excessive lateral OFC activity in concert with striatum. In this way, the clinical phenomena associated with the various anxiety disorders are linked to sub-territories of OFC, and understood in terms of their anatomical connections and the normal functions these neural circuits subserve.
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“Among these findings, abnormal activity in the ventromedial prefrontal cortex (vmPFC) is probably the most widely reported (1–4).”
From Functional anatomy of ventromedial prefrontal cortex: implications for mood and anxiety disorders (2012) · cites this paper as [3]
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Cites
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Neurons in medial prefrontal cortex signal memory for fear extinction
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Research works printed but not linked: 4
- Ferry,, 2000, Prefrontal cortical projections to the striatum in macaque monkeys:evidence for an organization related to prefrontal networks., J Comp Neurol, 10.1002/1096-9861(20000925)425:3〈447::AID-CNE9〉3.0.CO;2-V · DOI
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- McDonald,, 1996, Glutamate and aspartate immunoreactive neurons of the rat basolateral amygdala:colocalization of excitatory amino acids and projections to the limbic circuit., J Comp Neurol, 10.1002/(SICI)1096-9861(19960212)365:3〈367::AID-CNE3〉3.0.CO;2-2 · DOI
- Shin,, 2001, An fMRI study of anterior cingulate function in posttraumatic stress disorder., Biol Psychiatry, 10.1016/S0006-3223(01)01215-X · DOI · Paper page
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Functional anatomy of ventromedial prefrontal cortex: implications for mood and anxiety disorders
Myers-Schulz, B., & Koenigs, M. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.88 · Cited by 333
Metadata
- Authors
- Milad, M. R., & Rauch, S. L.
- Venue
- The Orbitofrontal Cortex
- Publisher
- Oxford University PressOxford
- Published
- 2006-10-12
- Pages
- 523-544
- OpenAlex
- W2494563539
- Cited by
- 11
- References
- 127
- Citations by year
- 2017: 1 · 2014: 1 · 2012: 1
- FWCI
- 1.67
- Type
- book chapter
- Language
- en
- Open access
- closed
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- orbitofrontal cortex, anxiety disorders, medial orbitofrontal cortex, lateral orbitofrontal cortex, fear extinction, fear conditioning, amygdala, top-down control, striatum, reward processing, negative affect
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