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Cited by 11Memory and Neural MechanismsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.

The orbitofrontal cortex and anxiety disorders

Milad, Mohammed R., Rauch, Scott L.·2006·The Orbitofrontal Cortex
DOI 10.1093/acprof:oso/9780198565741.003.0020
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Abstract

This chapter reviews contemporary neurocircuitry models of anxiety disorders, with a focus on the role of the orbitofrontal cortex (OFC). In addition to human neuroimaging studies, findings from animal research are also considered, with emphasis on fear conditioning and extinction paradigms. The anatomical distinction between medial and lateral OFC is highlighted; medial OFC has been implicated in rewards and conditioned fear extinction recall, whereas reciprocally the lateral OFC has been implicated in evaluating punishers and mediating negative affects. As similarities and differences across the anxiety disorders are explored, the distinction is made between: 1) exaggerated ‘bottom-up’ amygdala responses; 2) failure of ‘top-down’ control by the medial OFC; and 3) excessive lateral OFC activity in concert with striatum. In this way, the clinical phenomena associated with the various anxiety disorders are linked to sub-territories of OFC, and understood in terms of their anatomical connections and the normal functions these neural circuits subserve.

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Crossref · 10.1093/acprof:oso/9780198565741.003.0020

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Research works printed but not linked: 4

  1. Ferry,, 2000, Prefrontal cortical projections to the striatum in macaque monkeys:evidence for an organization related to prefrontal networks., J Comp Neurol, 10.1002/1096-9861(20000925)425:3〈447::AID-CNE9〉3.0.CO;2-V · DOI
  2. Floyd,, 2000, Orbitomedial prefrontal cortical projections to distinct longitudinal columns of the periaqueductal gray in the rat., J Comp Neurol, 10.1002/1096-9861(20000710)422:4〈556::AID-CNE6〉3.0.CO;2-U · DOI
  3. McDonald,, 1996, Glutamate and aspartate immunoreactive neurons of the rat basolateral amygdala:colocalization of excitatory amino acids and projections to the limbic circuit., J Comp Neurol, 10.1002/(SICI)1096-9861(19960212)365:3〈367::AID-CNE3〉3.0.CO;2-2 · DOI
  4. Shin,, 2001, An fMRI study of anterior cingulate function in posttraumatic stress disorder., Biol Psychiatry, 10.1016/S0006-3223(01)01215-X · DOI · Paper page

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Metadata

Authors
Milad, M. R., & Rauch, S. L.
ORCID
Venue
The Orbitofrontal Cortex
Publisher
Oxford University PressOxford
Published
2006-10-12
Pages
523-544
DOI
10.1093/acprof:oso/9780198565741.003.0020
OpenAlex
W2494563539
Cited by
11
References
127
Citations by year
2017: 1 · 2014: 1 · 2012: 1
FWCI
1.67
Type
book chapter
Language
en
Open access
closed
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
orbitofrontal cortex, anxiety disorders, medial orbitofrontal cortex, lateral orbitofrontal cortex, fear extinction, fear conditioning, amygdala, top-down control, striatum, reward processing, negative affect

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