An fMRI study of anterior cingulate function in posttraumatic stress disorder
Abstract
Background Several recent neuroimaging studies have provided data consistent with functional abnormalities in anterior cingulate cortex in posttraumatic stress disorder (PTSD). In our study, we implemented a cognitive activation paradigm to test the functional integrity of anterior cingulate cortex in PTSD. Methods Eight Vietnam combat veterans with PTSD (PTSD Group) and eight Vietnam combat veterans without PTSD (non-PTSD Group) underwent functional magnetic resonance imaging (fMRI) while performing the Emotional Counting Stroop. In separate conditions, subjects counted the number of combat-related (Combat), generally negative (General Negative), and neutral (Neutral) words presented on a screen and pressed a button indicating their response. Results In the Combat versus General Negative comparison, the non-PTSD group exhibited significant fMRI blood oxygenation level-dependent signal increases in rostral anterior cingulate cortex, but the PTSD group did not. Conclusions These findings suggest a diminished response in rostral anterior cingulate cortex in the presence of emotionally relevant stimuli in PTSD. We speculate that diminished recruitment of this region in PTSD may, in part, mediate symptoms such as distress and arousal upon exposure to reminders of trauma.
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Other studies have observed no difference in amygdala activity between subjects with PTSD and control groups without the disorder.
“However, others have observed no difference between a group of subjects with PTSD and control groups consisting of subjects without the disorder (Clark et al., 2002;Ganzel et al., 2008;Shin et al., 2001).”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Shin et al., 2001
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Self-citation
- Authors
- Shin, L. M., Whalen, P. J., Pitman, R. K., Bush, G., Macklin, M. L., Lasko, N. B., Orr, S. P., McInerney, S. C., & Rauch, S. L.
- Affiliations
- Tufts University (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- Manchester VA Medical Center (US)
- Corresponding author
- Shin, Lisa M
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 50
- Issue
- 12
- Pages
- 932-942
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2025911957
- Cited by
- 604
- References
- 12
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 10 · 2023: 15 · 2022: 13 · 2021: 9 · 2020: 14 · 2019: 23 · 2018: 27 · 2017: 21 · 2016: 26 · 2015: 35 · 2014: 23 · 2013: 31 · 2012: 35
- FWCI
- 26.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh060219-05)
- National Institute of Mental Health (MH 60219, K01 MH-01866, K01-MH01611, K01MH001611, K01MH001866)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- post-traumatic stress disorder, anterior cingulate cortex, rostral anterior cingulate cortex, combat veterans, emotional Stroop task, emotional word processing, trauma reminders, hyperarousal
- MeSH terms
- Emotions, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Stress Disorders, Post-Traumatic, Veterans, Vietnam, Case-Control Studies, Prefrontal Cortex
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