The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
The effect of coingestion of fat on the glucose, insulin, and gastric inhibitory polypeptide responses to carbohydrate and protein
Abstract
In the present study we examined the effect of coingestion of 50 g fat (butter) on the postprandial glucose, insulin, and gastric inhibitory polypeptide responses to 50 g carbohydrate (potato) or 50 g protein (low fat veal) in eight normal subjects. The coingestion of fat with either carbohydrate or protein resulted in greatly increased gastric inhibitory polypeptide responses, the effect being more pronounced with carbohydrate. The addition of fat to a carbohydrate meal also reduced the postprandial glucose response. This could have been due to several factors including a delayed glucose absorption, secondary to a fat-induced inhibition of gastric emptying. However, despite the lower blood glucose levels in the presence of fat the insulin response was not reduced, suggesting a potentiation of insulin secretion in the presence of fat. Thus, despite the apparent improvement in glucose tolerance when carbohydrate is ingested together with fat, the accompanying potentiation of insulin secretion could form the basis of long-term changes in insulin sensitivity which accompany alterations in dietary fat intake.
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“different elements can affect the GI of a food, such as the presence of fat (Collier & O'Dea, 1983), the presence of protein (Granfeldt et al. 1991), the presence of some anti-nutrients (Thorne et al. 1983), and acidity or the presence of acidic compounds (Liljeberg et al. 1995;Liljeberg & Bjorck, 1996, 1998).”
From Glycaemic index methodology (2005) · cites this paper as Collier & O'Dea, 1983
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Cites
Dietary fibres, fibre analogues, and glucose tolerance: importance of viscosity.
Jenkins, D. J. A., Wolever, T. M. S., Leeds, A. R., Gassull, M. A., Haisman, P., Dilawari, J. B., Goff, D. V., Metz, G. L., & Alberti, K. G. M. M. (1978) · BMJ · doi:10.1136/bmj.1.6124.1392 · Cited by 1,175
STIMULATION OF INSULIN SECRETION BY GASTRIC INHIBITORY POLYPEPTIDE IN MAN. 1
Dupre, J., Ross, S. A., Watson, D., & Brown, J. C. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-37-5-826 · Cited by 860
Identification and Actions of Gastric Inhibitory Polypeptide
Brown, J. C., Dryburgh, J. R., ROSS, S. A., & DUPRÉ, J. (1975) · Elsevier eBooks · doi:10.1016/b978-0-12-571131-9.50017-7 · Cited by 336
Mechanisms of insulin resistance in obesity and noninsulin-dependent (type II) diabetes
Olefsky, J. M., & Kolterman, O. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90422-8 · Cited by 306
Physical factors Influencing postprandial glucose and insulin responses to starch
O’Dea, K., Nestel, P. J., & Antonoff, L. (1980) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.4.760 · Cited by 280
Self-citationGastric Inhibitory Polypeptide: Its Physiologic Release and Insulinotropic Action in the Dog
Pederson, R. A., Schubert, H., & Brown, J. C. (1975) · Diabetes · doi:10.2337/diab.24.12.1050 · Cited by 245
Ginsberg, H., Kimmerling, G., Olefsky, J. M., & Reaven, G. M. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107951 · Cited by 225
Gastric Inhibitory Polypeptide Enhanced Lipoprotein Lipase Activity in Cultured Preadipocytes
Eckel, R. H., Fujimoto, W. Y., & Brunzell, J. D. (1979) · Diabetes · doi:10.2337/diab.28.12.1141 · Cited by 219
The dietetic factor determining the glucose tolerance and sensitivity to insulin in healthy men.
Himsworth, H. P. (1935) · Cited by 214
The Insulinotropic Action of Gastric Inhibitory Polypeptide in the Perfused Isolated Rat Pancreas
Pederson, R. A., & Brown, J. C. (1976) · Endocrinology · doi:10.1210/endo-99-3-780 · Cited by 210
Research works printed but not linked: 2
- Olefsky, 1981, Mechanism of insulin resistance in obesity and non-insulin dependent (type 2) diabetes., Am I Med, 70, 1511
- Hunt, 1968, Regulation ofgastric emptying.In: Cook CF ed. Handbook of physiology., Section 6, Alimentary canal. Vol 4. Washington, DC: American Physiological Society, 19, 17
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Brouns, F., Bjorck, I., Frayn, K. N., Gibbs, A. L., Lang, V., Slama, G., & Wolever, T. M. S. (2005) · Nutrition Research Reviews · doi:10.1079/nrr2005100 · Cited by 1,093
The use of the glycemie Index in predicting the blood glucose response to mixed meals
Wolever, T., & Jenkins, D. (1986) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/43.1.167 · Cited by 645
Impact of postprandial glycaemia on health and prevention of disease
Blaak, E. E., Antoine, J. M., Benton, D., Björck, I., Bozzetto, L., Brouns, F. J. P. H., Diamant, M., Dye, L., Hulshof, T. G., Holst, J. J., et al. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01011.x · Cited by 513
Dietary Carbohydrate (Amount and Type) in the Prevention and Management of Diabetes
Sheard, N. F., Clark, N. G., Brand-Miller, J. C., Franz, M. J., Pi-Sunyer, F. X., Mayer-Davis, E., Kulkarni, K., & Geil, P. (2004) · Diabetes Care · doi:10.2337/diacare.27.9.2266 · Cited by 475
Evaluation of rice flour modified by extrusion cooking
Hagenimana, A., Ding, X., & Fang, T. (2005) · Journal of Cereal Science · doi:10.1016/j.jcs.2005.09.003 · Cited by 463
Metadata
- Authors
- Collier, G., & O'Dea, K.
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1983-06
- Volume
- 37
- Issue
- 6
- Pages
- 941-944
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2166634289
- Cited by
- 219
- References
- 23
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 4 · 2017: 6 · 2016: 12 · 2015: 8 · 2014: 7 · 2013: 11 · 2012: 5
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- postprandial blood glucose, insulin secretion, glucose-dependent insulinotropic polypeptide, carbohydrate digestion, protein digestion, gastric emptying, glucose absorption, insulin sensitivity, butter, potato, veal
- MeSH terms
- Adult, Blood Glucose, Dietary Carbohydrates, Dietary Fats, Dietary Proteins, Female, Gastric Inhibitory Polypeptide, Humans, Insulin, Male, Metabolism
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