The DOI matches its Crossref record; 20 of the 21 references it cites were found in a registry or an index.
Incomplete absorption of pure fructose in healthy subjects and the facilitating effect of glucose.
Abstract
Small-intestinal absorption of fructose was investigated in healthy human subjects by sequential breath-hydrogen measurements. Fifty-eight percent of 103 subjects produced greater than 20 microL H2/L after consuming 50 g pure fructose in water. About half of those who absorbed fructose incompletely (incomplete absorbers) had abdominal symptoms. Malabsorption of medium doses of pure fructose may therefore be common in man. When 25 g pure fructose was consumed, only 19% of 21 poor absorbers (of 50 g fructose) still produced excess breath H2. When glucose was taken with fructose, the frequency and amount of excessive breath H2 was substantially reduced. This facilitating phenomenon is not generally known but is important because in natural foods fructose occurs in association or in combination (as sucrose) with glucose. Plasma fructose responses were not lower in poor absorbers presumably because these responses depend more on how much fructose passes through the liver than on how much is absorbed.
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“Furthermore, ingestion of large amounts of fructose (alone) has been reported to cause gastrointestinal distress, and the capacity for intestinal absorption of fructose ingested alone has also been shown to be limited (Truswell et al. 1988; Fujisawa et al. 1993).”
From Fructose co‐ingestion to increase carbohydrate availability in athletes (2019) · cites this paper as Truswell et al. 1988
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Cited by
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Mechanisms of NAFLD development and therapeutic strategies
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Tappy, L., & Lê, K.-A. (2010) · Physiological Reviews · doi:10.1152/physrev.00019.2009 · Cited by 1,256
Rezaie, A. R., Buresi, M. C., Lembo, A. J., Lin, H. C., McCallum, R. W., Rao, S. S. C., Schmulson, M. J., Valdovinos, M. A., Zakko, S. F., & Pimentel, M. (2017) · The American Journal of Gastroenterology · doi:10.1038/ajg.2017.46 · Cited by 850
Sugar, Uric Acid, and the Etiology of Diabetes and Obesity
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Evidence‐based dietary management of functional gastrointestinal symptoms: The FODMAP approach
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Metadata
- Authors
- Truswell, A., Seach, J., & Thorburn, A.
- Affiliations
- The University of Sydney (AU)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1988-12
- Volume
- 48
- Issue
- 6
- Pages
- 1424-1430
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1900840642
- Cited by
- 189
- References
- 21
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 1 · 2022: 2 · 2021: 10 · 2020: 3 · 2019: 7 · 2018: 9 · 2017: 14 · 2016: 5 · 2015: 6 · 2014: 12 · 2013: 12 · 2012: 3
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Digestive system and related health
- Keywords
- fructose malabsorption, fructose absorption, breath hydrogen, small intestine, sucrose, abdominal symptoms, healthy volunteers
- MeSH terms
- Adult, Aged, Blood Glucose, Breath Tests, Female, Fructose, Glucose, Humans, Intestinal Absorption, Intestine, Small, Male, Middle Aged, Reference Values
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