Cited by 189Diet, Metabolism, and DiseaseGastrointestinal motility and disordersDigestive system and related health

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Incomplete absorption of pure fructose in healthy subjects and the facilitating effect of glucose.

Truswell, AS, Seach, JM, Thorburn, AW·1988·The American Journal of Clinical Nutrition

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Abstract

Small-intestinal absorption of fructose was investigated in healthy human subjects by sequential breath-hydrogen measurements. Fifty-eight percent of 103 subjects produced greater than 20 microL H2/L after consuming 50 g pure fructose in water. About half of those who absorbed fructose incompletely (incomplete absorbers) had abdominal symptoms. Malabsorption of medium doses of pure fructose may therefore be common in man. When 25 g pure fructose was consumed, only 19% of 21 poor absorbers (of 50 g fructose) still produced excess breath H2. When glucose was taken with fructose, the frequency and amount of excessive breath H2 was substantially reduced. This facilitating phenomenon is not generally known but is important because in natural foods fructose occurs in association or in combination (as sucrose) with glucose. Plasma fructose responses were not lower in poor absorbers presumably because these responses depend more on how much fructose passes through the liver than on how much is absorbed.

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Authors: Truswell, A., Seach, J., & Thorburn, A.
Affiliations: The University of Sydney (AU)
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 1988-12
Volume: 48
Issue: 6
Pages: 1424-1430
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/48.6.1424
OpenAlex: W1900840642
Cited by: 189
References: 21
Citations by year: 2026: 2 · 2025: 2 · 2024: 6 · 2023: 1 · 2022: 2 · 2021: 10 · 2020: 3 · 2019: 7 · 2018: 9 · 2017: 14 · 2016: 5 · 2015: 6 · 2014: 12 · 2013: 12 · 2012: 3
FWCI: 0.94
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Gastroenterology › Digestive system and related health
Keywords: fructose malabsorption, fructose absorption, breath hydrogen, small intestine, sucrose, abdominal symptoms, healthy volunteers
MeSH terms: Adult, Aged, Blood Glucose, Breath Tests, Female, Fructose, Glucose, Humans, Intestinal Absorption, Intestine, Small, Male, Middle Aged, Reference Values

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Incomplete absorption of pure fructose in healthy subjects and the facilitating effect of glucose.

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