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Metabolic response to experimental overfeeding in lean and overweight healthy volunteers
Abstract
Possible adaptive mechanisms that may defend against weight gain during periods of excessive energy intake were investigated by overfeeding six lean and three overweight young men by 50% above baseline requirements with a mixed diet for 42 d [6.2 +/- 1.9 MJ/d (mean +/- SD), or a total of 265 +/- 45 MJ]. Mean weight gain was 7.6 +/- 1.6 kg (58 +/- 18% fat). The energy cost of tissue deposition (28.7 +/- 4.4 MJ/kg) matched the theoretical cost (26.0 MJ/kg). Basal metabolic rate (BMR) increased by 0.9 +/- 0.4 MJ/d and daily energy expenditure assessed by whole-body calorimetry (CAL EE) increased by 1.8 +/- 0.5 MJ/d. Total free-living energy expenditure (TEE) measured by doubly labeled water increased by 1.4 +/- 2.0 MJ/d. Activity and thermogenesis (computed as CAL EE--BMR and TEE--BMR) increased by only 0.9 +/- 0.4 and 0.9 +/- 2.1 MJ/d, respectively. All outcomes were consistent with theoretical changes due to the increased fat-free mass, body weight, and energy intake. There was no evidence of any active energy-dissipating mechanisms.
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“With continuous overfeeding, body energy stored was 60–75 % of excess energy leaving the rest for an increase in EE which was explained by obligatory costs”
From Changes in energy expenditure with weight gain and weight loss in humans (2016) · cites this paper as [10]
In the citing paper
“numerous well-controlled studies could not confirm mass-independent increases in REE and/or DIT during chronic overfeeding (for reviews see [9–15]).”
From Changes in energy expenditure with weight gain and weight loss in humans (2016) · cites this paper as [10]
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Hill, J. O., Wyatt, H. R., & Peters, J. C. (2012) · Circulation · doi:10.1161/circulationaha.111.087213 · Cited by 1,317
Role of Nonexercise Activity Thermogenesis in Resistance to Fat Gain in Humans
Levine, J. A., Eberhardt, N. L., & Jensen, M. D. (1999) · Science · doi:10.1126/science.283.5399.212 · Cited by 997
The Progressive Increase of Food Waste in America and Its Environmental Impact
Hall, K. D., Guo, J., Dore, M., & Chow, C. C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007940 · Cited by 748
“Figure 2A demonstrates that our model accurately calculated the energy intake changes underlying the observed weight gain in two controlled over-feeding experiments [19,20] and Figure 2B shows that our model accurately predicted the relationship between weight change and energy expenditure in longitudinal data from a…”
MethodNeurobiology of food intake in health and disease
Morton, G. J., Meek, T. H., & Schwartz, M. W. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3745 · Cited by 748
Obesity Pathogenesis: An Endocrine Society Scientific Statement
Schwartz, M. W., Seeley, R. J., Zeltser, L. M., Drewnowski, A., Ravussin, E., Redman, L. M., & Leibel, R. L. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00111 · Cited by 727
Metadata
- Authors
- Diaz, E., Prentice, A., Goldberg, G., Murgatroyd, P., & Coward, W.
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1992-10
- Volume
- 56
- Issue
- 4
- Pages
- 641-655
- ISSN
- 0002-9165
- Cited by
- 157
- References
- 0
- Language
- en
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