The effect of red and white wines on nonheme-iron absorption in humans
Abstract
The effect of the phenolic compounds in wine was examined in this study by performing radioiron-absorption measurements from extrinsically labeled test meals in 33 human subjects. In four separate studies we observed that absorption was 2- to 3-fold higher from white wine containing a low concentration of polyphenols than from two red wines containing a 10-fold higher concentration of polyphenols. The interaction between the polyphenols and alcohol in wine was evaluated by reducing the alcohol content of the wines by approximately 90%. When the alcohol concentration was reduced, there was a significant 28% decrease in nonheme-iron absorption with red wine but no effect with white wine. The inhibitory effect of red wines with reduced alcohol content was about twofold greater when they were consumed with a small bread roll than when taken without food. Our findings indicate that the inhibitory effect of phenolic compounds in red wine is unlikely to affect iron balance significantly.
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Inhibition by Assam tea, peppermint tea and cocoa in the absence of the bread roll (84-97%) is much higher than the 20-25% inhibition reported for red wine in a previous study.
“This is much higher than the 20-25 % inhibition reported for red wine in our previous study (Cook et al. 1995) but indicates that a polyphenol-Fe complex was formed in the intestinal lumen and that Fe within the complex was unavailable for absorption.”
From Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages (1999) · cites this paper as Cook et al. 1995
Red wine and cocoa, as well as various vegetables with a high polyphenol content, have been reported to inhibit Fe absorption.
“Other beverages such as red wine (Bezwoda et al. 1985;Cook et al. 1995) and cocoa (Gillooly et al. 1984), as well as various vegetables with a high polyphenol content (Gillooly et al. 1983;Tuntawiroon et al. 1991), have also been reported to inhibit Fe absorption.”
From Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages (1999) · cites this paper as Cook et al. 1995
Cites
Salonen, J. T., Nyyssönen, K., Korpela, H., Tuomilehto, J., Seppänen, R., & Salonen, R. (1992) · Circulation · doi:10.1161/01.cir.86.3.803 · Cited by 1,284 · see citing works
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Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significance
Bravo, L. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1998.tb01670.x · Cited by 4,030 · see citing works
Iron bioavailability and dietary reference values
Hurrell, R., & Egli, I. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.28674f · Cited by 1,359 · see citing works
Self-citationInhibition of non-haem iron absorption in man by polyphenolic-containing beverages
Hurrell, R. F., Reddy, M., & Cook, J. D. (1999) · British Journal of Nutrition · doi:10.1017/s0007114599000537 · Cited by 490 · see citing works
Self-citation
- Authors
- Cook, J., Reddy, M., & Hurrell, R.
- Affiliations
- University of Kansas Medical Center (US)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1995-04
- Volume
- 61
- Issue
- 4
- Pages
- 800-804
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1865153746
- Cited by
- 103
- References
- 1
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 6
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk039246-05)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 39246)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- red wine, white wine, nonheme iron absorption, polyphenols, alcohol, iron bioavailability, iron balance, dietary iron
- MeSH terms
- Adult, Female, Flavonoids, Humans, Intestinal Absorption, Iron, Male, Phenols, Polymers, Wine, Polyphenols
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