High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men
Abstract
BACKGROUND: Iron can induce lipid peroxidation in vitro and in vivo in humans and has promoted ischemic myocardial injury in experimental animals. We tested the hypothesis that high serum ferritin concentration and high dietary iron intake are associated with an excess risk of acute myocardial infarction. METHODS AND RESULTS: Randomly selected men (n = 1,931), aged 42, 48, 54, or 60 years, who had no symptomatic coronary heart disease at entry, were examined in the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) in Eastern Finland between 1984 and 1989. Fifty-one of these men experienced an acute myocardial infarction during an average follow-up of 3 years. On the basis of a Cox proportional hazards model adjusting for age, examination year, cigarette pack-years, ischemic ECG in exercise test, maximal oxygen uptake, systolic blood pressure, blood glucose, serum copper, blood leukocyte count, and serum high density lipoprotein cholesterol, apolipoprotein B, and triglyceride concentrations, men with serum ferritin greater than or equal to 200 micrograms/l had a 2.2-fold (95% CI, 1.2-4.0; p less than 0.01) risk factor-adjusted risk of acute myocardial infarction compared with men with a lower serum ferritin. An elevated serum ferritin was a strong risk factor for acute myocardial infarction in all multivariate models. This association was stronger in men with serum low density lipoprotein cholesterol concentration of 5.0 mmol/l (193 mg/dl) or more than in others. Also, dietary iron intake had a significant association with the disease risk in a Cox model with the same covariates. CONCLUSIONS: Our data suggest that a high stored iron level, as assessed by elevated serum ferritin concentration, is a risk factor for coronary heart disease.
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Cites
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works
Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425 · see citing works
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994 · see citing works
Cardiovascular Survey Methods.
Rose, G., & Blackburn, H. (1968) · Annals of Internal Medicine · doi:10.7326/0003-4819-69-6-1335_2 · Cited by 3,065 · see citing works
BMPD statistical software manual
Dixon, W. (1988) · University of California Press eBooks · Cited by 2,536 · see citing works
Oxygen radicals and human disease
CROSS, C. E., HALLIWELL, B., BORISH, E. T., PRYOR, W. A., AMES, B. N., SAUL, R. L., McCORD, J. M., & HARMAN, D. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-526 · Cited by 1,856 · see citing works
Seven Countries: A Multivariate Analysis of Death and Coronary Heart Disease.
(1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-5-786_2 · Cited by 1,425 · see citing works
Autoantibody against oxidised LDL and progression of carotid atherosclerosis
Salonen, J. T., Korpela, H., Salonen, R., Nyyssönen, K., Ylä‐Herttuala, S., Yamamoto, R., Butler, S., Palinski, W., & Witztum, J. L. (1992) · The Lancet · doi:10.1016/0140-6736(92)90926-t · Cited by 1,311 · see citing works
IRON AND THE SEX DIFFERENCE IN HEART DISEASE RISK
Sullivan, J. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92463-6 · Cited by 969 · see citing works
Menopause and Coronary Heart Disease
Gordon, T., Kannel, W. B., Hjortland, M. C., & McNAMARA, P. M. (1978) · Annals of Internal Medicine · doi:10.7326/0003-4819-89-2-157 · Cited by 904 · see citing works
Salonen, J., Alfthan, G., Huttunen, J. K., Pikkarainen, J., & Puska, P. (1982) · The Lancet · doi:10.1016/s0140-6736(82)91028-5 · Cited by 576 · see citing works
Serum ferritin as a measure of iron stores in normal subjects
Cook, J. D., Lipschitz, D. A., Miles, L. E. M., & Finch, C. A. (1974) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/27.7.681 · Cited by 568 · see citing works
Evaluation of the iron status of a population
Cook, J., Finch, C. A., & Smith, N. (1976) · Blood · doi:10.1182/blood.v48.3.449.449 · Cited by 468 · see citing works
Smith, C., Mitchinson, M. J., Aruoma, O. I., & Halliwell, B. (1992) · Biochemical Journal · doi:10.1042/bj2860901 · Cited by 455 · see citing works
Ferritin: structure, biosynthesis, and role in iron metabolism.
Munro, H. N., & Linder, M. C. (1978) · Physiological Reviews · doi:10.1152/physrev.1978.58.2.317 · Cited by 404 · see citing works
Prevention of Cardiac Disease by Subcutaneous Deferoxamine in Patients with Thalassemia Major
Wolfe, L. C., Olivieri, N. F., Sallan, D., Colan, S. D., Rose, V., Propper, R. D., Freedman, M. H., & Nathan, D. G. (1985) · New England Journal of Medicine · doi:10.1056/nejm198506203122503 · Cited by 262 · see citing works
The iron paradigm of ischemic heart disease
Sullivan, J. L. (1989) · American Heart Journal · doi:10.1016/0002-8703(89)90887-9 · Cited by 241 · see citing works
Assay Using Brain Homogenate for Measuring the Antioxidant Activity of Biological Fluids
Stocks, J., Gutteridge, J. M. C., Sharp, R. J., & Dormandy, T. L. (1974) · Clinical Science · doi:10.1042/cs0470215 · Cited by 234 · see citing works
Interactions of serum copper, selenium, and low density lipoprotein cholesterol in atherogenesis.
Salonen, J. T., Salonen, R. M., Seppänen, K., Kantola, M., Suntioinen, S., & Korpela, H. (1991) · BMJ · doi:10.1136/bmj.302.6779.756 · Cited by 205 · see citing works
Salonen, J. T., Salonen, R. M., Korpela, H., Suntioinen, S., & Tuomilehto, J. (1991) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116080 · Cited by 175 · see citing works
Risk factors for ischaemic vascular death for men in the Stockholm prospective study
Böttiger, L. E., & Carlson, L. A. (1980) · Atherosclerosis · doi:10.1016/0021-9150(80)90219-1 · Cited by 115 · see citing works
Nontransferrin-bound iron in plasma from hemochromatosis patients: effect of phlebotomy therapy
Aruoma, O., Bomford, A. B., Polson, R., & Halliwell, B. B. (1988) · Blood · doi:10.1182/blood.v72.4.1416.1416 · Cited by 110 · see citing works
TUOMILETHTO, J., Arstila, M., Kaarsalo, E., Kankaanpää, J., Ketonen, M., Kuulasmaa, K., Lehto, S., Miettinen, H., Mustaniemi, H., Palomäki, P., et al. (1992) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a060329 · Cited by 97 · see citing works
Is iron sufficiency a risk factor in ischemic heart disease?
McCord, J. M. (1991) · Circulation · doi:10.1161/01.cir.83.3.1112 · Cited by 94 · see citing works
Iron detoxifying activity of ferritin
Cozzi, A., Santambrogio, P., Levi, S., & Arosio, P. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80823-2 · Cited by 85 · see citing works
Iron stores and the international variation in mortality from coronary artery disease
Lauffer, R. B. (1991) · Medical Hypotheses · doi:10.1016/0306-9877(91)90030-3 · Cited by 58 · see citing works
WHO MONICA Project: Assessing CHD Mortality and Morbidity
WHO MONICA Project (1989) · International Journal of Epidemiology · doi:10.1093/ije/18.supplement_1.s38 · Cited by 56 · see citing works
Ihanainen, M., Salonen, R. M., Seppänen, R., & Salonen, J. T. (1989) · Nutrition Research · doi:10.1016/s0271-5317(89)80126-5 · Cited by 45 · see citing works
Prevalence of iron deficiency and iron overload in the adult icelandic population
Jónsson, J. J., Jóhannesson, G. M., Sigfússon, N., Magnusson, B., Þjóðleifsson, B., & Magnússon, S. (1991) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(91)90090-v · Cited by 44 · see citing works
Itabe, H., Kobayashi, T., & Keizo, I. (1988) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(88)90125-7 · Cited by 40 · see citing works
Xanthine oxidase induced depolymerization of hyaluronic acid in the presence of ferritin
Carlin, G., & Djursäter, R. (1984) · FEBS Letters · doi:10.1016/0014-5793(84)80974-6 · Cited by 35 · see citing works
Knottnerus, J. A., Swaen, G. M. H., Slangen, J. J. M., Volovics, A., & Durinck, J. R. (1988) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(88)90010-8 · Cited by 29 · see citing works
6 Diagnosis and clinical evaluation of iron overload
Kaltwasser, J. P., & Werner, E. (1989) · Baillière s Clinical Haematology · doi:10.1016/s0950-3536(89)80022-8 · Cited by 28 · see citing works
RAISED HAEMOGLOBIN AND RISK OF CARDIOVASCULAR DISEASE
Cullen, K. J., STENHOUSE, N. S., & Wearne, K. L. (1981) · The Lancet · doi:10.1016/s0140-6736(81)91524-5 · Cited by 26 · see citing works
Exercise as prevention: Do the health benefits derive in part from lower iron levels?
Lauffer, R. B. (1991) · Medical Hypotheses · doi:10.1016/0306-9877(91)90031-s · Cited by 23 · see citing works
Treatment of resistant hypertension by phlebotomy
Zidek, W., Tenschert, W., Karoff, C., & Vetter, H. (1985) · Journal of Molecular Medicine · doi:10.1007/bf01733828 · Cited by 23 · see citing works
Free radicals and low-density lipoprotein oxidation by macrophages
Wilkins, G. M., & Leake, D. S. (1990) · Biochemical Society Transactions · doi:10.1042/bst0181170 · Cited by 19 · see citing works
Korpela, H. (1990) · Annals of Nutrition and Metabolism · doi:10.1159/000177586 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958 · see citing works
The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
Lakka, H.-M. (2002) · JAMA · doi:10.1001/jama.288.21.2709 · Cited by 5,033 · see citing works
Dietary polyphenols and the prevention of diseases
Scalbert, A., Manach, C., Morand, C., Rémésy, C., & Jiménez, L. (2005) · Critical Reviews in Food Science and Nutrition · doi:10.1080/1040869059096 · Cited by 2,999 · see citing works
Besarab, A., Bolton, W. K., Browne, J. K., Egrie, J. C., Nissenson, A. R., Okamoto, D. M., Schwab, S. J., & Goodkin, D. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808273390903 · Cited by 1,930 · see citing works
The role of oxidized lipoproteins in atherogenesis
Berliner, J. A., & Heinecke, J. W. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02173-6 · Cited by 1,365 · see citing works
Micha, R., Wallace, S. K., & Mozaffarian, D. (2010) · Circulation · doi:10.1161/circulationaha.109.924977 · Cited by 1,244 · see citing works
Melatonin as a natural ally against oxidative stress: a physicochemical examination
Galano, A., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00916.x · Cited by 1,154 · see citing works
Biomarkers of Nutrition for Development—Folate Review
Bailey, L. B., Stover, P. J., McNulty, H., Fenech, M. F., Gregory, J. F., Mills, J. L., Pfeiffer, C. M., Fazili, Z., Zhang, M., Ueland, P. M., et al. (2015) · Journal of Nutrition · doi:10.3945/jn.114.206599 · Cited by 1,147 · see citing works
Goyer, R. A., & Clarkson, T. W. (1991) · Cited by 1,128 · see citing works
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Healthful and Unhealthful Plant-Based Diets and the Risk of Coronary Heart Disease in U.S. Adults
Satija, A., Bhupathiraju, S. N., Spiegelman, D., Chiuve, S. E., Manson, J. E., Willett, W., Rexrode, K. M., Rimm, E. B., & Hu, F. B. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.05.047 · Cited by 991 · see citing works
Lakka, T. A., Venalainen, J. M., Rauramaa, R., Salonen, R., Tuomilehto, J., & Salonen, J. T. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406023302201 · Cited by 793 · see citing works
A permease-oxidase complex involved in high-affinity iron uptake in yeast.
Stearman, R., Yuan, D. S., Yamaguchi-Iwai, Y., Klausner, R. D., & Dancis, A. (1996) · Science · doi:10.1126/science.271.5255.1552 · Cited by 683 · see citing works
Kell, D. B., & Pretorius, E. (2014) · Metallomics · doi:10.1039/c3mt00347g · Cited by 667 · see citing works
Uric Acid Level as a Risk Factor for Cardiovascular and All-Cause Mortality in Middle-aged Men
NISKANEN, L. K., Laaksonen, D. E., Nyyssönen, K., Alfthan, G., Lakka, H., Lakka, T. A., & Salonen, J. T. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.14.1546 · Cited by 664 · see citing works
Laaksonen, D. E., Lakka, H.-M., Salonen, J. T., Niskanen, L. K., Rauramaa, R., & Lakka, T. A. (2002) · Diabetes Care · doi:10.2337/diacare.25.9.1612 · Cited by 657 · see citing works
Knovich, M. A., Storey, J. A., Coffman, L. G., Torti, S. V., & Torti, F. M. (2008) · Blood Reviews · doi:10.1016/j.blre.2008.08.001 · Cited by 666 · see citing works
Bioavailability of iron, zinc, and other trace minerals from vegetarian diets
Hunt, J. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.633s · Cited by 637 · see citing works
Balla, J., Jacob, H. S., Balla, G., Nath, K. A., Eaton, J. W., & Vercellotti, G. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9285 · Cited by 591 · see citing works
Salonen, J. T., Seppänen, K., Nyyssönen, K., Korpela, H., Kauhanen, J., Kantola, M., Tuomilehto, J., Esterbauer, H., Tatzber, F., & Salonen, R. (1995) · Circulation · doi:10.1161/01.cir.91.3.645 · Cited by 578 · see citing works
Lynch, J. W., Kaplan, G. A., Cohen, R. D., Tuomilehto, J., & Salonen, J. T. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008863 · Cited by 547 · see citing works
Commentary: Vitamin C: Antioxidant or Pro-Oxidant In Vivo?
Halliwell, B. (1996) · Free Radical Research · doi:10.3109/10715769609149066 · Cited by 531 · see citing works
Heart rate and the cardiovascular risk
Palatini, P., & Julius, S. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715010-00001 · Cited by 508 · see citing works
Micha, R., Michas, G., & Mozaffarian, D. (2012) · Current Atherosclerosis Reports · doi:10.1007/s11883-012-0282-8 · Cited by 502 · see citing works
Macdougall, I. C., Bircher, A. J., Eckardt, K., Obrador, G. T., Pollock, C. A., Stenvinkel, P., Swinkels, D. W., Wanner, C., Weiß, G., Chertow, G. M., et al. (2016) · Kidney International · doi:10.1016/j.kint.2015.10.002 · Cited by 488 · see citing works
Association of low serum concentration of bilirubin with increased risk of coronary artery disease
Schwertner, H. A., Jackson, W. G., & Tolan, G. D. (1994) · Clinical Chemistry · doi:10.1093/clinchem/40.1.18 · Cited by 472 · see citing works
Surface, corrosion and biocompatibility aspects of Nitinol as an implant material.
Shabalovskaya, S. A. (2002) · PubMed · Cited by 429 · see citing works
Body Iron Stores and the Risk of Carotid Atherosclerosis: Prospective Results From the Bruneck Study
Kiechl, S., Willeit, J., Egger, G., Poewe, W., & Oberhollenzer, F. (1997) · Circulation · doi:10.1161/01.cir.96.10.3300 · Cited by 390 · see citing works
Phytic acid in health and disease
Zhou, J. R., & Erdman, J. W. (1995) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408399509527712 · Cited by 381 · see citing works
Human disease, free radicals, and the oxidant/antioxidant balance
McCord, J. M. (1993) · Clinical Biochemistry · doi:10.1016/0009-9120(93)90111-i · Cited by 376 · see citing works
Drüeke, T. B., Witko‐Sarsat, V., Massy, Z. A., Descamps‐Latscha, B., Guérin, A. P., Marchais, S. J., Gausson, V., & London, G. M. (2002) · Circulation · doi:10.1161/01.cir.0000035250.66458.67 · Cited by 375 · see citing works
Iron Toxicity in Diseases of Aging: Alzheimer's Disease, Parkinson's Disease and Atherosclerosis
Altamura, S., & Muckenthaler, M. U. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1010 · Cited by 369 · see citing works
Preventing Iron Deficiency Through Food Fortification
Hurrell, R. F. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1997.tb01608.x · Cited by 362 · see citing works
Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361 · see citing works
Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection
Galano, A., & Reiter, R. J. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12514 · Cited by 361 · see citing works
Association of age, sex, and race with body iron stores in adults: Analysis of NHANES III data
Zacharski, L. R., Ornstein, D. L., Woloshin, S., & Schwartz, L. M. (2000) · American Heart Journal · doi:10.1067/mhj.2000.106646 · Cited by 349 · see citing works
Dietary Supplements and Mortality Rate in Older Women
Mursu, J. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.445 · Cited by 339 · see citing works
Serum Ferritin as a Component of the Insulin Resistance Syndrome
Fernández-Real, J.-M., Ricart-Engel, W., Arroyo, E., Balançá, R., Casamitjana-Abella, R., Cabrero, D., Fernández-Castañer, M., & Soler, J. (1998) · Diabetes Care · doi:10.2337/diacare.21.1.62 · Cited by 328 · see citing works
Biomarkers of Nutrition for Development (BOND)—Iron Review
Lynch, S. R., Pfeiffer, C. M., Georgieff, M., Brittenham, G. M., Fairweather‐Tait, S. J., Hurrell, R. F., McArdle, H. J., & Raiten, D. J. (2018) · Journal of Nutrition · doi:10.1093/jn/nxx036 · Cited by 348 · see citing works
Blood Letting in High-Ferritin Type 2 Diabetes
Fernández‐Real, J. M., Peñarroja, G., Castro, A., Garcia-Bragado, F., Hernández‐Aguado, I., & Ricart, W. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1000 · Cited by 333 · see citing works
Virtanen, J. K., Voutilainen, S., Rissanen, T., Mursu, J., Tuomainen, T., Korhonen, M. J., Valkonen, V.-P., Seppänen, K., Laukkanen, J. A., & Salonen, J. T. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000150040.20950.61 · Cited by 327 · see citing works
Erythropoietin, iron, and erythropoiesis.
Goodnough, L. T., Skikne, B., & Brugnara, C. (2000) · PubMed · Cited by 310 · see citing works
Vinchi, F., Porto, G., Simmelbauer, A., Altamura, S., Passos, S., Garbowski, M., Silva, A. M. N., Spaich, S., Seide, S., Sparla, R., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz112 · Cited by 308 · see citing works
Iron deficiency and cardiovascular disease
von Haehling, S., Jankowska, E. A., van Veldhuisen, D. J., Ponikowski, P. P., & Anker, S. D. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.109 · Cited by 307 · see citing works
The development of mitochondrial medicine.
Luft, R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8731 · Cited by 302 · see citing works
Systolic Blood Pressure Response to Exercise Stress Test and Risk of Stroke
Kurl, S., Laukkanen, J. A., Rauramaa, R., Lakka, T. A., Sivenius, J., & Salonen, J. T. (2001) · Stroke · doi:10.1161/hs0901.095395 · Cited by 302 · see citing works
Erythropoietin, iron, and erythropoiesis
Goodnough, L. T., Skikne, B., & Brugnara, C. (2000) · Blood · doi:10.1182/blood.v96.3.823 · Cited by 299 · see citing works
Cardiovascular Fitness as a Predictor of Mortality in Men
Laukkanen, J. A., Lakka, T. A., Rauramaa, R., Kuhanen, R., Venäläinen, J. M., Salonen, R. M., & Salonen, J. T. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.6.825 · Cited by 291 · see citing works
Eid, R., Arab, N. T. T., & Greenwood, M. T. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.12.002 · Cited by 286 · see citing works
Association Between Body Iron Stores and the Risk of Acute Myocardial Infarction in Men
Tuomainen, T.-P., Punnonen, K., Nyyssönen, K., & Salonen, J. T. (1998) · Circulation · doi:10.1161/01.cir.97.15.1461 · Cited by 286 · see citing works
Mechanisms of copper- and iron-dependent oxidative modification of human low density lipoprotein
Lynch, S. M., & Frei, B. B. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)35737-0 · Cited by 285 · see citing works
Galano, A., & Alvarez-Idaboy, J. R. (2018) · International Journal of Quantum Chemistry · doi:10.1002/qua.25665 · Cited by 282 · see citing works
Kauhanen, J., Kaplan, G. A., Goldberg, D. E., & Salonen, J. T. (1997) · BMJ · doi:10.1136/bmj.315.7112.846 · Cited by 278 · see citing works
n−3 Fatty acids and cardiovascular disease risk factors among the Inuit of Nunavik
Dewailly, É., Blanchet, C., Lemieux, S., Sauvé, L., Gingras, S., Ayotte, P., & Holub, B. J. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.4.464 · Cited by 275 · see citing works
Moderate elevation of body iron level and increased risk of cancer occurrence and death
Stevens, R. G., Graubard, B. I., Micozzi, M. S., Neriishi, K., & Blumberg, B. S. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910560312 · Cited by 276 · see citing works
Erythropoietin, iron, and erythropoiesis
Goodnough, L. T., Skikne, B., & Brugnara, C. (2000) · Blood · doi:10.1182/blood.v96.3.823.015k49_823_833 · Cited by 357 · see citing works
Iron Chelation Improves Endothelial Function in Patients With Coronary Artery Disease
Duffy, S. J., Biegelsen, E. S., Holbrook, M., Russell, J. D., Gokce, N., Keaney, J. F., & Vita, J. A. (2001) · Circulation · doi:10.1161/01.cir.103.23.2799 · Cited by 271 · see citing works
Frei, B. B., & Gaziano, J. M. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)35354-2 · Cited by 270 · see citing works
Rissanen, T. H., Voutilainen, S., Virtanen, J. K., Venho, B., Vanharanta, M., Mursu, J., & Salonen, J. T. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.1.199 · Cited by 260 · see citing works
Haddad, E. H., Berk, L., Kettering, J. D., Hubbard, R. W., & Peters, W. R. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.3.586s · Cited by 259 · see citing works
Nyyssonen, K., Parviainen, M. T., Salonen, R., Tuomilehto, J. O., & Salonen, J. T. (1997) · BMJ · doi:10.1136/bmj.314.7081.634 · Cited by 256 · see citing works
THOMPSON, A., & DANESH, J. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01644.x · Cited by 252 · see citing works
Body Iron Stores and the Risk of Coronary Heart Disease
Sempos, C. T., Looker, A. C., Gillum, R. F., & Makuc, D. M. (1994) · New England Journal of Medicine · doi:10.1056/nejm199404213301604 · Cited by 251 · see citing works
Iron, Atherosclerosis, and Ischemic Heart Disease
de Valk, B., & Marx, J. J. M. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.14.1542 · Cited by 250 · see citing works
Vanharanta, M., Voutilainen, S., Lakka, T. A., van der Lee, M., Adlercreutz, H., & Salonen, J. T. (1999) · The Lancet · doi:10.1016/s0140-6736(99)05031-x · Cited by 246 · see citing works
Self-citationSantos, J. S., Brizola, V. R. A., & Granato, D. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.07.091 · Cited by 246 · see citing works
Roest, M., van der Schouw, Y. T., de Valk, B., Marx, J. J. M., Tempelman, M. J., de Groot, P. G., Sixma, J. J., & Banga, J. D. (1999) · Circulation · doi:10.1161/01.cir.100.12.1268 · Cited by 245 · see citing works
Heme Oxygenases in Cardiovascular Health and Disease
Ayer, A., Zarjou, A., Agarwal, A., & Stocker, R. (2016) · Physiological Reviews · doi:10.1152/physrev.00003.2016 · Cited by 243 · see citing works
Lipoprotein Oxidation and Progression of Carotid Atherosclerosis
Salonen, J. T., ̈nen, K. N., Salonen, R. M., Porkkala-Sarataho, E., Tuomainen, T., Diczfalusy, U., & Björkhem, I. (1997) · Circulation · doi:10.1161/01.cir.95.4.840 · Cited by 241 · see citing works
Iron Deficiency: Contemporary Scientific Issues and International Programmatic Approaches
Yip, R. (1994) · Journal of Nutrition · doi:10.1093/jn/124.suppl_8.1479s · Cited by 238 · see citing works
Iron absorption from the whole diet in men: how effective is the regulation of iron absorption?
Hallberg, L., Hultén, L., & Gramatkovski, E. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.347 · Cited by 237 · see citing works
Keaton, J. M., Kamali, Z., Xie, T., Vaez, A., Williams, A., Goleva, S. B., Ani, A., Εvangelou, Ε., Hellwege, J. N., Yengo, L., et al. (2024) · Nature Genetics · doi:10.1038/s41588-024-01714-w · Cited by 232 · see citing works
Iron, Free Radicals, and Oxidative Injury
McCord, J. M. (2004) · Journal of Nutrition · doi:10.1093/jn/134.11.3171s · Cited by 232 · see citing works
Tuomainen, T., KONTULA, K. K., Nyyssönen, K., Lakka, T. A., Heliö, T. M., & Salonen, J. T. (1999) · Circulation · doi:10.1161/01.cir.100.12.1274 · Cited by 232 · see citing works
Marniemi, J., Alanen, E., Impivaara, O., Seppänen, R., Hakala, P., Rajala, T., & Rönnemaa, T. (2005) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2005.01.001 · Cited by 231 · see citing works
Coronary Heart Disease and Iron Status: Meta-Analyses of Prospective Studies
Danesh, J., & Appleby, P. (1999) · Circulation · doi:10.1161/01.cir.99.7.852 · Cited by 226 · see citing works
Association of Serum Bilirubin Concentration with Risk of Coronary Artery Disease
Mayer, M. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.11.1723 · Cited by 223 · see citing works
Vitamins and minerals: efficacy and safety
Hathcock, J. N. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.427 · Cited by 221 · see citing works
Burt, M. J., George, P. M., Upton, J. D., Collett, J. A., Frampton, C. M., Chapman, T. M., Walmsley, T. A., & CHAPMAN, B. A. (1998) · Gut · doi:10.1136/gut.43.6.830 · Cited by 220 · see citing works
Baynes, R. D. (1996) · Clinical Biochemistry · doi:10.1016/0009-9120(96)00010-k · Cited by 215 · see citing works
Ghosh, G. C., Khan, M. J. H., Chakraborty, T. K., Zaman, S., Kabir, A. H. M. E., & Tanaka, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-62187-5 · Cited by 214 · see citing works
Metabolic Syndrome and the Risk of Stroke in Middle-Aged Men
Kurl, S., Laukkanen, J. A., NISKANEN, L. K., Laaksonen, D. E., Sivenius, J., Nyyssönen, K., & Salonen, J. T. (2006) · Stroke · doi:10.1161/01.str.0000204354.06965.44 · Cited by 211 · see citing works
Low Dietary Folate Intake Is Associated With an Excess Incidence of Acute Coronary Events
Voutilainen, S., Rissanen, T., Virtanen, J. K., Lakka, T. A., & Salonen, J. T. (2001) · Circulation · doi:10.1161/01.cir.103.22.2674 · Cited by 209 · see citing works
Overview and Mechanisms of Iron Regulation
Bothwell, T. H. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1995.tb05480.x · Cited by 207 · see citing works
Liyana‐Pathirana, C. M., & Shahidi, F. (2005) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2374 · Cited by 203 · see citing works
Iron deficiency and cardiovascular disease
Savarese, G., von Haehling, S., Butler, J., Cleland, J. G. F., Ponikowski, P. P., & Anker, S. D. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac569 · Cited by 203 · see citing works
Ferroptosis: the potential value target in atherosclerosis
Ouyang, S., You, J., Zhi, C., Li, P., Lin, X., Tan, X., Ma, W., Li, L., & Xie, W. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04054-3 · Cited by 203 · see citing works
Kristenson, M., Ziedén, B., Kučinskienė, Z. A., Abaravičius, A., Razinkovienė, L., Elinder, L. S., Bergdahl, B., Elwing, B., Čalkauskas, H., & OLSSON, A. G. (1997) · BMJ · doi:10.1136/bmj.314.7081.629 · Cited by 201 · see citing works
Evaluation of oxidative stress in patients with hyperlipidemia
Araujo, F., Barbosa, D. S., Chang, Y. H., Maranhão, R. C., & Abdalla, D. S. P. (1995) · Atherosclerosis · doi:10.1016/0021-9150(94)05558-z · Cited by 194 · see citing works
Chronic Iron Administration Increases Vascular Oxidative Stress and Accelerates Arterial Thrombosis
Day, S. M., Duquaine, D., Mundada, L. V., Menon, R. G., Khan, B. V., Rajagopalan, S., & Fay, W. P. (2003) · Circulation · doi:10.1161/01.cir.0000066910.02844.d0 · Cited by 192 · see citing works
Green tea or rosemary extract added to foods reduces nonheme-iron absorption
Samman, S., Sandström, B., Toft, M. B., Bukhave, K., Jensen, M., Sørensen, S. S., & Hansen, M. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.3.607 · Cited by 193 · see citing works
Administration of Parenteral Iron and Mortality among Hemodialysis Patients
Feldman, H. I., Joffe, M. M., Robinson, B. M., KNAUSS, J. S., Čižman, B., Guo, W., Franklin-Becker, E. D., & Faich, G. A. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000128009.69594.be · Cited by 193 · see citing works
Caries prediction – state of the art
Hausen, H. (1997) · Community Dentistry And Oral Epidemiology · doi:10.1111/j.1600-0528.1997.tb00904.x · Cited by 191 · see citing works
Blood Donations and Risk of Coronary Heart Disease in Men
Ascherio, A., Rimm, E. B., Giovannucci, E. L., Willett, W. C., & Stampfer, M. J. (2001) · Circulation · doi:10.1161/01.cir.103.1.52 · Cited by 193 · see citing works
The Fascinating but Deceptive Ferritin
Kalantar‐Zadeh, K., Kalantar‐Zadeh, K., & Lee, G. H. (2006) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.01390406 · Cited by 189 · see citing works
On risks and benefits of iron supplementation recommendations for iron intake revisited
Schümann, K., Ettle, T., Szegner, B., Elsenhans, B., & Solomons, N. W. (2007) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2007.06.002 · Cited by 189 · see citing works
Virtanen, J. K., Mursu, J., Voutilainen, S., & Tuomainen, T. (2009) · Circulation · doi:10.1161/circulationaha.109.852657 · Cited by 188 · see citing works
Islam, M. R., Akash, S., Jony, M. H., Alam, M. N. A., Nowrin, F. T., Rahman, M. M., Rauf, A., & Thiruvengadam, M. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04638-3 · Cited by 186 · see citing works
RetractedIron Deficiency: The Global Perspective
Cook, J. D., Skikne, B., & Baynes, R. D. (1994) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2554-7_24 · Cited by 183 · see citing works
A study of free radical chemistry: their role and pathophysiological significance.
Gutowski, M., & Kowalczyk, S. J. (2013) · Acta Biochimica Polonica · doi:10.18388/abp.2013_1944 · Cited by 182 · see citing works
- Authors
- Salonen, J. T., Nyyssönen, K., Korpela, H., Tuomilehto, J., Seppänen, R., & Salonen, R.
- Affiliations
- University of Eastern Finland (FI)
- Venue
- Circulation
- Published
- 1992-09
- Volume
- 86
- Issue
- 3
- Pages
- 803-811
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2065303599
- Cited by
- 1,284
- References
- 38
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 16 · 2023: 17 · 2022: 43 · 2021: 32 · 2020: 27 · 2019: 33 · 2018: 36 · 2017: 42 · 2016: 47 · 2015: 35 · 2014: 38 · 2013: 40 · 2012: 48
- FWCI
- 34.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- serum ferritin, stored iron, acute myocardial infarction, coronary heart disease risk, iron intake, lipid peroxidation, LDL cholesterol, men, Eastern Finland
- MeSH terms
- Adult, Aging, Diet, Dose-Response Relationship, Drug, Ferritins, Finland, Hemoglobins, Humans, Iron, Cholesterol, LDL, Male, Middle Aged, Myocardial Infarction, Risk Factors, Smoking, Proportional Hazards Models
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