The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Low-density-lipoprotein subclasses and response to a low-fat diet in healthy men
Abstract
Lipid and lipoprotein responses to reduced dietary fat intake were investigated in relation to differences in distribution of low-density-lipoprotein (LDL) subclasses among 105 healthy men consuming high-fat (46% fat) and low-fat (24% fat) diets in random order for 6 wk each. With high-fat diets, 87 subjects had predominantly large, buoyant LDL (pattern A), whereas the remainder had primarily smaller, denser LDL (pattern B). With low-fat diets, 36 men changed from pattern A to B. Compared with the 51 men with pattern A with both diets (stable A group), men in the stable B group (n = 18) had significantly greater reductions in plasma LDL cholesterol, apolipoprotein B, and mass of mid-sized (LDL II) and small (LDL III) LDL subfractions. In both the stable A and change groups, there was a shift in LDL particle mass from larger, lipid-enriched (LDL I and II) to smaller, lipid-depleted (LDL III and IV) subfractions, suggestive of change in LDL composition with minimal change in particle number, and consistent with the observation of reduced plasma LDL cholesterol without reduced apolipoprotein B. Stable B subjects had significantly greater increases in the largest very-low-density-lipoprotein subfraction with the low-fat diet than the stable A group, and also had greater decreases in the high-density-lipoprotein (HDL) subclass HDL3 but smaller reductions in HDL2. Genetic and environmental factors influencing LDL subclass distributions thus may also contribute substantially to interindividual variation in plasma lipoprotein response to a low-fat diet.
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“19 We have previously reported that pattern B is characterized by interrelated 20 metabolic differences from pattern A including increased triglycerides, reduced 21 HDL-C (18), and recently, insulin resistance (19,20).”
BackgroundSelf-citationA prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction.
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Sources of data for developing and maintaining a nutrient database.
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Cited by
Sorted by citations
Metabolic origins and clinical significance of LDL heterogeneity
Berneis, K. K., & Krauss, R. M. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200004-jlr200 · Cited by 896
“small LDL phenotype (152, 153), and contribute to varia-”
BackgroundSelf-citationAn Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing
Pennacchio, L. A., Olivier, M., Hubacek, J. A., Cohen, J. C., Cox, D. R., Fruchart, J.-C., Krauss, R. M., & Rubin, E. M. (2001) · Science · doi:10.1126/science.1064852 · Cited by 921
McLaughlin, T., Reaven, G. M., Abbasi, F., Lamendola, C. A., Saad, M. F., Waters, D. D., Simon, J., & Krauss, R. M. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.03.085 · Cited by 659
Saturated fat, carbohydrate, and cardiovascular disease
Siri-Tarino, P. W., Sun, Q., Hu, F. B., & Krauss, R. M. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26285 · Cited by 636
Parks, E. J., & Hellerstein, M. K. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.412 · Cited by 530
“Dreon et al (153) reported that a switch from a HF (16:46:38) to a LF-HC diet (16:24:60) caused a 14% reduction in HDL cho- FIGURE 2.”
Background
Metadata
- Authors
- Krauss, R., & Dreon, D.
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1995-08
- Volume
- 62
- Issue
- 2
- Pages
- 478S-487S
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2098213415
- Cited by
- 144
- References
- 61
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2018: 2 · 2016: 2 · 2015: 5 · 2014: 3 · 2013: 1 · 2012: 5
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01hl018574-26)
- National Heart, Lung, and Blood Institute (HL-18574)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- LDL particle size, low-fat diet, dietary fat reduction, LDL cholesterol, apolipoprotein B, VLDL, HDL subfractions, HDL3, HDL2, interindividual variability, serum lipoproteins, healthy men
- MeSH terms
- Adult, Aged, Apolipoproteins B, Dietary Fats, Humans, Lipids, Cholesterol, HDL, Lipoproteins, LDL, Cholesterol, LDL, Male, Middle Aged, Models, Biological, Regression Analysis, Body Mass Index, Cross-Over Studies, Diet, Fat-Restricted
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