CoChat
Sign Up
Cited by 232Diet, Metabolism, and DiseaseDiabetes, Cardiovascular Risks, and LipoproteinsNutritional Studies and Diet

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Effects of low-fat, high-carbohydrate diets on risk factors for ischemic heart disease in postmenopausal women

Open access
Jeppesen, J, Schaaf, P, Jones, C, Zhou, MY, Chen, YD, Reaven, GM·1997·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/65.4.1027
Open this paper in CoChat — free account

Abstract

The effects of variations in dietary carbohydrate and fat on various aspects of carbohydrate and lipoprotein metabolism were evaluated in 10 healthy, postmenopausal women. The two diets were isoenergetic, assigned in random fashion, and consisted (as a % of total energy) of 15% protein, 60% carbohydrate, and 25% fat (60%-carbohydrate diet) or 15% protein, 40% carbohydrate, and 45% fat (40%-carbohydrate diet). Fasting plasma triacylglycerol, very-low-density-lipoprotein (VLDL) triacylglycerol, and VLDL-cholesterol concentrations were higher (P < 0.05-0.001) after the 60%-carbohydrate diet, whereas high-density-lipoprotein (HDL) cholesterol was lower (P < 0.05). Plasma insulin and triacylglycerol concentrations were also higher (P < 0.001) from 0800 to 0000 with the 60%-carbohydrate diet than with the 40%-carbohydrate diet. In addition, when vitamin A was given with the noon meal, the ensuing concentrations of retinyl palmitate were also higher after ingestion of the 60%-carbohydrate diet. Resistance to insulin-mediated glucose disposal, quantified at baseline by determining the steady state plasma glucose (SSPG) concentration at the end of a 180-min infusion of somatostatin, insulin, and glucose, correlated with the incremental increases in postprandial concentrations of plasma glucose (r = 0.68, P = 0.06), insulin (r = 0.82, P < 0.02), triacylglycerol (r = 0.77, P < 0.05), and retinyl palmitate (r = 0.68, P = 0.06) and with the Sf > 400 triacylglycerol (r = 0.77, P < 0.05), Sf 20-400 triacylglycerol (r = 0.72, P < 0.05), and Sf > 400 retinyl palmitate (r = 0.75, P < 0.01) lipoprotein fractions. Because all of these changes would increase risk of ischemic heart disease in postmenopausal women, it seems reasonable to question the wisdom of recommending that postmenopausal women consume low-fat, high-carbohydrate diets.

Overview

Integrity signals

Registry

Crossref · 10.1093/ajcn/65.4.1027

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 2

  1. Mensink, 1992, Effect of dietary fatty acids on serum lipids and lipoproteins., ArteriosclerThromb, 12, 911
  2. Patsch, 1992, Relation of triglyceride metabolism and coronary artery disease., ArteriosclerThromb, 12, 1336

Cited by

Sorted by citations

See all 232

Related

See all

Metadata

Authors
Jeppesen, J., Schaaf, P., Jones, C., Zhou, M., Chen, Y., & Reaven, G.
Affiliations
Stanford Medicine (US)
ORCID
Jeppesen, J
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
1997-04
Volume
65
Issue
4
Pages
1027-1033
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/65.4.1027
OpenAlex
W1831066255
Cited by
232
References
51
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2021: 10 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 7 · 2014: 9 · 2013: 4 · 2012: 13
FWCI
8.54
Type
journal article
Language
en
Update notices
erratum (1997-08-01)
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL08506)
  • National Center for Research Resources (RR 00 070, M01RR000070)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
low-fat high-carbohydrate diet, dietary carbohydrates, dietary fat, postmenopausal women, ischemic heart disease risk factors, lipoprotein metabolism, HDL cholesterol, insulin resistance, insulin-stimulated glucose disposal, postprandial lipemia, retinyl palmitate, vitamin A, plasma insulin, plasma triglycerides
MeSH terms
Retinyl Esters, Aged, Blood Glucose, Cholesterol, Dietary Carbohydrates, Dietary Fats, Diterpenes, Female, Humans, Insulin, Insulin Resistance, Cholesterol, HDL, Middle Aged, Risk Factors, Triglycerides, Vitamin A, Myocardial Ischemia, Postmenopause, Diet, Fat-Restricted, Carbohydrate Metabolism, Lipid Metabolism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review