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Cited by 697Lipoproteins and Cardiovascular HealthLipid metabolism and disordersDiabetes, Cardiovascular Risks, and Lipoproteins

Plasma triglyceride and coronary heart disease

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Austin, M A·1991·Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
DOI 10.1161/01.atv.11.1.2
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Abstract

Although the literature on epidemiological associations between plasma triglyceride and CHD is not completely consistent, trends do emerge from the studies described here. First, the majority of observational studies demonstrate a significant univariate relation, although the results of case-control and cross-sectional studies are more uniform than those from prospective study designs. In many but not all studies, triglyceride remains a significant predictor of CHD in multivariate statistical analyses after controlling for TC or LDL-C. Perhaps the least consistent result is that the triglyceride association does not persist in some analyses controlling for HDL-C, while in other studies, the association remains significant. Although most studies have been conducted in men, the studies providing data on women, normocholesterolemic subjects, and diabetic subjects have generally found triglyceride to be, at the very least, a univariate risk factor. The results of intervention trials differ considerably, but no such study to date has been specifically designed to evaluate triglyceride-lowering effects on primary prevention of CHD. Important statistical properties must be taken into consideration in evaluating triglyceride as a risk factor for CHD. The large variability of triglyceride measurements and the correlation of triglyceride values with other lipid measures appears to result in the underestimation of the association between triglyceride and disease in multivariate analyses. Finally, individual genetic susceptibility may play an important role in the relation between plasma triglyceride levels and CHD. For example, risk of CHD clearly varies among the well-established familial forms of hypertriglyceridemia. A predominance of small, dense, LDL particles (LDL subclass pattern B) also appears to be a genetic trait associated with both increased risk of MI and increases in plasma triglyceride levels.

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Authors
Austin, M. A.
Affiliations
University of Washington (US)
Corresponding author
Austin, M A
Venue
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1991-01
Volume
11
Issue
1
Pages
2-14
ISSN
1049-8834 (ISSN-L)
DOI
10.1161/01.atv.11.1.2
OpenAlex
W2155238815
Cited by
697
References
98
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 5 · 2014: 5 · 2013: 13 · 2012: 8
FWCI
15.24
Type
journal article
Language
en
Open access
Locations
  • Arteriosclerosis and Thrombosis A Journal of Vascular Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (7r29hl038760-03)
  • National Heart, Lung, and Blood Institute (HL38760, P01HL030086, HL3-0086)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
plasma triglycerides, coronary artery disease, cardiovascular risk factors, hypertriglyceridemia, familial hypertriglyceridemia, small dense LDL, HDL cholesterol, genetic susceptibility, primary prevention, lipid-lowering intervention
MeSH terms
Coronary Disease, Female, Humans, Male, Pedigree, Triglycerides, Multivariate Analysis

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