The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Decreased bioavailability of vitamin D in obesity
Open accessAbstract
Background Obesity is associated with vitamin D insufficiency and secondary hyperparathyroidism.Objective This study assessed whether obesity alters the cutaneous production of vitamin D(3) (cholecalciferol) or the intestinal absorption of vitamin D(2) (ergocalciferol).Design Healthy, white, obese [body mass index (BMI; in kg/m(2)) > or = 30] and matched lean control subjects (BMI </= 25) received either whole-body ultraviolet radiation or a pharmacologic dose of vitamin D(2) orally.Results Obese subjects had significantly lower basal 25-hydroxyvitamin D concentrations and higher parathyroid hormone concentrations than did age-matched control subjects. Evaluation of blood vitamin D(3) concentrations 24 h after whole-body irradiation showed that the incremental increase in vitamin D(3) was 57% lower in obese than in nonobese subjects. The content of the vitamin D(3) precursor 7-dehydrocholesterol in the skin of obese and nonobese subjects did not differ significantly between groups nor did its conversion to previtamin D(3) after irradiation in vitro. The obese and nonobese subjects received an oral dose of 50000 IU (1.25 mg) vitamin D(2). BMI was inversely correlated with serum vitamin D(3) concentrations after irradiation (r = -0.55, P: = 0.003) and with peak serum vitamin D(2) concentrations after vitamin D(2) intake (r = -0.56, P: = 0.007).Conclusions Obesity-associated vitamin D insufficiency is likely due to the decreased bioavailability of vitamin D(3) from cutaneous and dietary sources because of its deposition in body fat compartments.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Emerging data also support a direct relationship between bone and fat16, 17.”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [16]
Citations
Cites
Experimental Design: Procedures for the Behavioral Sciences
Kirk, R. (2013) · doi:10.4135/9781483384733 · Cited by 8,539
Aging decreases the capacity of human skin to produce vitamin D3.
MacLaughlin, J. A., & Holick, M. F. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112134 · Cited by 1,442
Self-citationExperimental design: Procedures for the behavioral sciences (3rd ed.).
Kirk, R. E. (1995) · Cited by 787
Photosynthesis of Previtamin D 3 in Human Skin and the Physiologic Consequences
Holick, M. F., MacLaughlin, J. A., Clark, M. B., Holick, S. A., Potts, J. T. J., Anderson, R. R., Blank, I. H., Parrish, J. A., & Elias, P. M. (1980) · Science · doi:10.1126/science.6251551 · Cited by 778
Self-citationEvidence for alteration of the vitamin D-endocrine system in obese subjects.
Bell, N. H., Epstein, S., Greene, A. S., Shary, J., Oexmann, M. J., & Shaw, S. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111971 · Cited by 685
Sunscreens Suppress Cutaneous Vitamin D3Synthesis*
Matsuoka, L. Y., IDE, L., Wortsman, J., MacLaughlin, J. A., & Holick, M. F. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-6-1165 · Cited by 600
Self-citationLow circulating vitamin D in obesity
Liel, Y., Ulmer, E., Shary, J., Hollis, B. W., & Bell, N. H. (1988) · Calcified Tissue International · doi:10.1007/bf02555135 · Cited by 388
Racial Pigmentation and the Cutaneous Synthesis of Vitamin D
Matsuoka, L. Y. (1991) · Archives of Dermatology · doi:10.1001/archderm.1991.04510010104011 · Cited by 302
Self-citationEffects of skin thickness, age, body fat, and sunlight on serum 25-hydroxyvitamin D
Need, A. G., Morris, H., Horowitz, M., & Nordin, C. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.6.882 · Cited by 301
Vitamin D status and bone histomorphometry in gross obesity
Compston, J. E., Vedi, S., Ledger, J. E., Webb, A., Gazet, J. C., & Pilkington, T. R. (1981) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/34.11.2359 · Cited by 249
Cited by
Sorted by citations
Holick, M. F., Binkley, N., Bischoff-Ferrari, H. A., Gordon, C. M., Hanley, D. A., Heaney, R. P., Murad, M. H., & Weaver, C. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0385 · Cited by 10,961
Self-citationClinician’s Guide to Prevention and Treatment of Osteoporosis
Cosman, F., de Beur, S. J., LeBoff, M. S., Lewiecki, E. M., Tanner, B., Randall, S., & Lindsay, R. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2794-2 · Cited by 4,149
“This regimen should be followed by maintenance therapy of 1500–2000 IU/day or whatever dose is needed to maintain the target blood level [37, 38].”
BackgroundHolick, M. F. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1678s · Cited by 2,799
Self-citationVitamin D deficiency: a worldwide problem with health consequences
Holick, M. F., & Chen, T. C. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.1080s · Cited by 2,689
Self-citationHigh Prevalence of Vitamin D Inadequacy and Implications for Health
Holick, M. F. (2006) · Mayo Clinic Proceedings · doi:10.4065/81.3.353 · Cited by 2,037
Self-citation
Metadata
- Authors
- Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z., & Holick, M. F.
- Affiliations
- SIU Medicine (US)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2000-09
- Volume
- 72
- Issue
- 3
- Pages
- 690-693
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2157304718
- Cited by
- 3,204
- References
- 19
- Citations by year
- 2026: 73 · 2025: 89 · 2024: 97 · 2023: 138 · 2022: 190 · 2021: 173 · 2020: 177 · 2019: 158 · 2018: 183 · 2017: 194 · 2016: 189 · 2015: 213 · 2014: 215 · 2013: 231 · 2012: 193
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR369637)
- National Center for Research Resources (MO1 RR 00533, M01RR000533)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
- Keywords
- obesity, vitamin D bioavailability, vitamin D insufficiency, 25-hydroxyvitamin D, parathyroid hormone, secondary hyperparathyroidism, UV irradiation, 7-dehydrocholesterol, previtamin D3, vitamin D2, body fat storage
- MeSH terms
- Adult, Biological Availability, Cholecalciferol, Ergocalciferols, Humans, Intestinal Absorption, Obesity, Reference Values, Skin, Ultraviolet Rays, Vitamin D, Body Mass Index
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
