Vitamin D status and bone histomorphometry in gross obesity
Abstract
Plasma 25-hydroxyvitamin D concentrations and bone histomorphometry were investigated in 24 grossly obese subjects. The mean plasma 25OHD concentration was significantly lower in the obese group than in age-matched, healthy controls. Subnormal values were found in four obese subjects and in a further two subjects, who were investigated at the end of the summer, plasma 25-hydroxyvitamin D levels were at the lower end of the normal winter range. Bone histology was abnormal in two patients. In one, mild osteomalacia and secondary hyperparathyroidism were present while in the other patient the appearance suggested increased bone turnover, possibly as a result of healing osteomalacia. We conclude that gross obesity is associated with an increased risk of vitamin D deficiency, probably because of reduced exposure to uv radiation. Histological evidence of metabolic bone disease may also occur. Preoperative vitamin D deficiency may contribute in some patients to the development of metabolic bone disease after intestinal bypass.
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Hyperparathyroidism is common.
“Hyperparathyroidism is common, and while this may be secondary to vitamin D deficiency, an independent relationship between PTH and obesity has been reported14, 15.”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [15]
Hyperparathyroidism may be secondary to vitamin D deficiency.
“Hyperparathyroidism is common, and while this may be secondary to vitamin D deficiency, an independent relationship between PTH and obesity has been reported14, 15.”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [15]
An independent relationship between PTH and obesity has been reported.
“Hyperparathyroidism is common, and while this may be secondary to vitamin D deficiency, an independent relationship between PTH and obesity has been reported14, 15.”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [15]
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- Authors
- Compston, J. E., Vedi, S., Ledger, J. E., Webb, A., Gazet, J. C., & Pilkington, T. R.
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1981-11
- Volume
- 34
- Issue
- 11
- Pages
- 2359-2363
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2199079318
- Cited by
- 249
- References
- 12
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 8 · 2020: 6 · 2019: 13 · 2018: 10 · 2017: 12 · 2016: 13 · 2015: 18 · 2014: 19 · 2013: 11 · 2012: 14
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Keywords
- vitamin D deficiency, 25-hydroxyvitamin D, bone histomorphometry, osteomalacia, secondary hyperparathyroidism, bone turnover, metabolic bone disease, UV exposure, bariatric surgery, intestinal bypass
- MeSH terms
- Adult, Bone and Bones, Bone Resorption, Calcifediol, Calcification, Physiologic, Female, Humans, Hydroxycholecalciferols, Male, Middle Aged, Obesity, Seasons
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