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Cited by 351Bone health and osteoporosis researchMenopause: Health Impacts and TreatmentsNutritional Studies and Diet

Nutritional associations with bone loss during the menopausal transition: Evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids

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Macdonald, Helen M, New, Susan A, Golden, Michael HN, Campbell, Marion K, Reid, David M·2004·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/79.1.155
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Abstract

Background The menopausal transition is characterized by rapid bone loss. Few data exist on the role of nutrition.Objective The objective of the study was to ascertain which dietary factors influence perimenopausal skeletal loss.Design A longitudinal study was conducted of 891 women aged 45-55 y at baseline and 50-59 y at follow-up 5-7 y later. Bone mineral density (BMD) was measured by using dual-energy X-ray absorptiometry at the lumbar spine and femoral neck (FN). Nutrient intakes were assessed after the baseline visit and 5 y later, by using the same food-frequency questionnaire.Results After adjustment for energy intake and other confounders, higher intakes of calcium were correlated with change in FN BMD (ie, reduced loss) (r = 0.073, P < 0.05), and the intake of modest amounts of alcohol was associated with less lumbar spine bone loss (P < 0.01 for quartile of alcohol intake). Greater FN BMD loss was associated with increased intake of polyunsaturated fatty acids (r = -0.110, P < 0.01), monounsaturated fatty acids (r = -0.069, P < 0.05), retinol (r = -0.067; P < 0.05), and vitamin E (r = -0.110; P < 0.01). The latter 2 nutrients were highly correlated with polyunsaturated fatty acids. For premenopausal women, calcium and nutrients found in fruit and vegetables (vitamin C, magnesium, and potassium) were associated with FN BMD, and calcium, vitamin C, and magnesium were associated with change in FN BMD.Conclusions Although menopausal status and hormone replacement therapy use dominate women's bone health, diet may influence early postmenopausal bone loss. Fruit and vegetable intake may protect against premenopausal bone loss.

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  • Organic nitrate NO donors such as glycerol trinitrate, isosorbide dinitrate, and mononitrate all have beneficial effects on experimental and clinical osteoporosis, and a number of epidemiological studies indicated that high fruit and vegetable intake appears protective against osteoporosis in men and pre- and postmenopausal women.

    “In this context, it has been shown that organic nitrate NO donors, such as glycerol trinitrate, isosorbide dinitrate and mononitrate all have beneficial effects on experimental and clinical osteoporosis [161,162,163], and a number of epidemiological studies also indicated that a high fruit and vegetable intake appears to have a protective effect against osteoporosis in men and pre- and post”

    From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [166]

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Authors
Macdonald, H. M., New, S. A., Golden, M. H., Campbell, M. K., & Reid, D. M.
Affiliations
University of Aberdeen (GB)
Corresponding author
Macdonald, Helen M
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2004-01
Volume
79
Issue
1
Pages
155-165
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/79.1.155
OpenAlex
W2115438773
Cited by
351
References
79
Citations by year
2026: 3 · 2025: 6 · 2024: 13 · 2023: 11 · 2022: 4 · 2021: 8 · 2020: 14 · 2019: 13 · 2018: 16 · 2017: 9 · 2016: 12 · 2015: 21 · 2014: 18 · 2013: 20 · 2012: 31
FWCI
22.05
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
perimenopause, bone loss, bone mineral density, calcium intake, alcohol consumption, polyunsaturated fatty acids, monounsaturated fatty acids, retinol, vitamin E, fruit and vegetable intake, vitamin C, magnesium, potassium, postmenopausal bone loss, dietary factors
MeSH terms
Ethanol, Calcium, Dietary, Diet, Fatty Acids, Female, Fruit, Humans, Longitudinal Studies, Middle Aged, Nutritional Physiological Phenomena, Vegetables, Bone Density, Osteoporosis, Postmenopausal

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