Patterns and predictors of folic acid supplement use among pregnant women: the Norwegian Mother and Child Cohort Study
Open accessAbstract
Background Patterns and predictors of maternal folic acid supplement use have not been examined in large prospective studies of pregnant women.Objective We examined the patterns and predictors of maternal folic acid supplement use from 2 mo before pregnancy through the eighth month of pregnancy.Design Data from 22 500 women in the Norwegian Mother and Child Cohort Study with deliveries recorded in 2000-2003 were analyzed.Results Folic acid supplement use increased from 11.8% at 2 mo before pregnancy to 46.9% at gestational month 3, but decreased to 26.0% at gestational month 8. Of 16 116 women (71.6%) who had taken folic acid supplements at some time before or during pregnancy, 72.4% had started use after becoming pregnant. Ten percent of the women had used supplements regularly from 1 mo before pregnancy throughout the first trimester. These women more frequently reported higher maternal and paternal education, planned pregnancies, infertility treatments, or chronic diseases. They were also more likely to be older, married, and nonsmokers and to have higher income and lower parity.Conclusions Most women started folic acid supplementation too late with respect to the prevention of neural tube defects. More effective intervention programs to improve periconceptional intakes of folic acid are needed and should consider both demographic and socioeconomic factors.
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Nutritional impact in pregnancy after bariatric surgery is unclear, and although supplement use is widely recommended following bariatric surgery and for pregnant women, poor compliance is a problem.
“Also, nutritional impact in pregnancy is unclear and although supplement use is widely recommended following bariatric surgery and for pregnant women, poor compliance is a problem. 269”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [269]
Cites
Czeizel, A. E., & Dudás, I. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212243272602 · Cited by 3,200 · see citing works
Prevention of Neural-Tube Defects with Folic Acid in China
Berry, R. J., Li, Z., Erickson, J. D., Li, S., Moore, C. A., Wang, H., Mulinare, J., Zhao, P., Wong, L.-Y., Gindler, J., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199911113412001 · Cited by 1,353 · see citing works
Prevention of Neural-Tube Defects with Folic Acid in China
(1999) · New England Journal of Medicine · doi:10.1056/nejm199912093412424 · Cited by 1,075 · see citing works
Botto, L. D., Moore, C. A., Khoury, M. J., & Erickson, J. D. (1999) · New England Journal of Medicine · doi:10.1056/nejm199911113412006 · Cited by 1,000 · see citing works
The Medical Birth Registry of Norway. Epidemiological research and surveillance throughout 30 years
Irgens, L. M. (2000) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1034/j.1600-0412.2000.079006435.x · Cited by 836 · see citing works
POSSIBLE PREVENTION OF NEURAL-TUBE DEFECTS BY PERICONCEPTIONAL VITAMIN SUPPLEMENTATION
SMITHELLS, R. W., Sheppard, S., Schorah, C. J., Seller, M. J., Nevin, N. C., Harris, R., Read, A., & Fielding, D. W. (1980) · The Lancet · doi:10.1016/s0140-6736(80)90886-7 · Cited by 657 · see citing works
Folic acid: influence on the outcome of pregnancy
Scholl, T. O., & Johnson, W. G. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.5.1295s · Cited by 617 · see citing works
Dietary and serum folate: their influence on the outcome of pregnancy
Scholl, T., Hediger, M. L., Schall, J., Khoo, C., & Fischer, R. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.4.520 · Cited by 278 · see citing works
Botto, L. D., Lisi, A., Robert‐Gnansia, E., et al. (2005) · BMJ · doi:10.1136/bmj.38336.664352.82 · Cited by 246 · see citing works
Robbins, A. S., Chao, S. Y., & Fonseca, V. P. (2002) · Annals of Epidemiology · doi:10.1016/s1047-2797(01)00278-2 · Cited by 183 · see citing works
Hertrampf, E., Cortés, F. M., Marisol Cayazzo, C., Erickson, J. D., Freire, W. B., Bailey, L. B., Howson, C., KAUWELL, G. P. A., & Pfeiffer, C. M. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3166 · Cited by 173 · see citing works
Charles, D., Ness, A., Campbell, D. M., Smith, G. D., Whitley, E., & Hall, M. H. (2005) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2005.00633.x · Cited by 115 · see citing works
Trends and predictors of folic acid awareness and periconceptional use in pregnant women
den Berg, L. T. W. D. J., Hernández–Dı́az, S., Werler, M. M., Louik, C., & Mitchell, A. A. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.05.085 · Cited by 108 · see citing works
Risk of Gestational Hypertension in Relation to Folic Acid Supplementation during Pregnancy
Hernández–Dı́az, S. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf129 · Cited by 99 · see citing works
Ray, J. G., Vermeulen, M. J., Boss, S. C., & Cole, D. E. C. (2002) · Epidemiology · doi:10.1097/00001648-200203000-00026 · Cited by 96 · see citing works
Folate Supplementation and Twin Pregnancies
Vollset, S. E., Gjessing, H. K. K., Tandberg, A., et al. (2005) · Epidemiology · doi:10.1097/01.ede.0000152914.84962.13 · Cited by 90 · see citing works
Self-citationBrevik, A., Vollset, S. E., Tell, G. S., et al. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.81.2.434 · Cited by 79 · see citing works
Self-citationCorrelates of intake of folic acid–containing supplements among pregnant women
Carmichael, S. L., Shaw, G. M., Yang, W., Laurent, C. A., Herring, A. H., Royle, M. H., Canfield, M. A., & Study, T. N. B. D. P. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.06.018 · Cited by 72 · see citing works
Knudsen, V. K., Orozova-Bekkevold, I. M., Rasmussen, L. B., et al. (2004) · Public Health Nutrition · doi:10.1079/phn2004630 · Cited by 67 · see citing works
Morrell, M. J. (2002) · Epiliepsy currents/Epilepsy currents · doi:10.1046/j.1535-7597.2002.00017.x · Cited by 65 · see citing works
Determinants of folic acid knowledge and use among antenatal women
McDonnell, R., Johnson, Z., Doyle, A., et al. (1999) · Journal of Public Health · doi:10.1093/pubmed/21.2.145 · Cited by 64 · see citing works
Sen, S., Manzoor, A., Deviasumathy, M., et al. (2001) · Public Health Nutrition · doi:10.1079/phn2001123 · Cited by 54 · see citing works
Daltveit, A. K., Vollset, S. E., Lande, B., & Øien, H. (2004) · Scandinavian Journal of Public Health · doi:10.1080/14034940310019515 · Cited by 53 · see citing works
Self-citationPericonceptional use of folic acid supplements in Oslo
Brække, K., & Staff, A. C. (2003) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1034/j.1600-0412.2003.00180.x · Cited by 49 · see citing works
Folic Acid Use by Women Receiving Routine Gynecologic Care
Cleves, M. A., Hobbs, C. A., Collins, H. B., Andrews, N., Smith, L. N., & Robbins, J. M. (2004) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000117084.02395.a0 · Cited by 39 · see citing works
Achieving a public health recommendation for preventing neural tube defects with folic acid.
Werler, M. M., Louik, C., & Mitchell, A. A. (1999) · American Journal of Public Health · doi:10.2105/ajph.89.11.1637 · Cited by 33 · see citing works
Use of vitamins containing folic acid among women of childbearing age--United States, 2004.
(2004) · PubMed · Cited by 28 · see citing works
Morrell, M. J. (2002) · Epiliepsy currents/Epilepsy currents · doi:10.1111/j.1535-7597.2002.00017.x · Cited by 25 · see citing works
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Balen, A. H., Morley, L. C., Misso, M., Franks, S., Legro, R. S., Wijeyaratne, C. N., Stener-Victorin, E., Fauser, B. C. J. M., Norman, R. J., & Teede, H. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw025 · Cited by 705 · see citing works
Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline
Teede, H. J., Misso, M. L., Deeks, A. A., Moran, L. J., Stuckey, B. G. A., Wong, J. L. A., Norman, R. J., Costello, M. F., & Groups, O. B. O. T. G. D. (2011) · Medical Journal of Australia · doi:10.5694/mja11.10915 · Cited by 379 · see citing works
Association between maternal age and birth defects of unknown etiology ― United States, 1997–2007
Gill, S. K., Broussard, C., Devine, O., Green, R. F., Rasmussen, S. A., Reefhuis, J., & Study, A. T. N. B. D. P. (2012) · Birth Defects Research Part A: Clinical and Molecular Teratology · doi:10.1002/bdra.23049 · Cited by 153 · see citing works
Julvez, J., Fortuny, J., Mendez, M., Torrent, M., Ribas‐Fitó, N., & Sunyer, J. (2009) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2009.01032.x · Cited by 150 · see citing works
Ogundipe, O., Hoyo, C., Østbye, T., Oneko, O., Manongi, R., Lie, R. T., & Daltveit, A. K. (2012) · BMC Public Health · doi:10.1186/1471-2458-12-481 · Cited by 114 · see citing works
Antenatal iron and folic acid supplementation use by pregnant women in Khartoum, Sudan
Abdullahi, H., Gasim, G. I., Saeed, A., Imam, A. M., & Adam, I. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-498 · Cited by 88 · see citing works
Sengpiel, V., Bacelis, J., Myhre, R., Myking, S., Devold Pay, A. S., Haugen, M., Brantsæter, A.-L., Meltzer, H. M., Nilsen, R. M., Magnus, P., et al. (2014) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-014-0375-1 · Cited by 46 · see citing works
Self-citationChourasia, A., Pandey, C. M., & Awasthi, A. (2017) · Clinical Epidemiology and Global Health · doi:10.1016/j.cegh.2017.04.004 · Cited by 41 · see citing works
- Authors
- Nilsen, R. M., Vollset, S. E., Gjessing, H. K., Magnus, P., Meltzer, H. M., Haugen, M., & Ueland, P. M.
- Affiliations
- Norwegian Institute of Public Health (NO)
- Corresponding author
- Nilsen, Roy M
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 84
- Issue
- 5
- Pages
- 1134-1141
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1864680902
- Cited by
- 153
- References
- 28
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 10 · 2021: 4 · 2020: 17 · 2019: 7 · 2018: 7 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 10 · 2013: 13 · 2012: 13
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- UCLA - Biblioteca de Ciencias de la Salud (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- folic acid supplementation, pregnant women, periconceptional period, neural tube defects, supplement use patterns, predictors of supplement use, maternal education, socioeconomic factors, planned pregnancy, infertility treatment, parity, Norwegian Mother and Child Cohort Study
- MeSH terms
- Adult, Awareness, Educational Status, Family Planning Services, Female, Folic Acid, Humans, Health Knowledge, Attitudes, Practice, Neural Tube Defects, Norway, Pregnancy, Prenatal Care, Prospective Studies, Time Factors, Vitamin B Complex, Cohort Studies, Health Behavior, Dietary Supplements, Prenatal Nutritional Physiological Phenomena
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