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Cited by 150Folate and B Vitamins ResearchPrenatal Substance Exposure EffectsPharmacological Effects and Toxicity Studies

Maternal use of folic acid supplements during pregnancy and four‐year‐old neurodevelopment in a population‐based birth cohort

Julvez, Jordi, Fortuny, Joan, Mendez, Michelle, Torrent, Maties, Ribas‐Fitó, Núria, Sunyer, Jordi·2009·Paediatric and Perinatal Epidemiology
DOI 10.1111/j.1365-3016.2009.01032.x
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Abstract

Summary: The use of folic acid supplements during very early pregnancy is recommended in order to reduce the incidence of neural tube defects. Little is known about the possible benefits of folic acid on child neurodevelopment. A total of 420 children (87% of those eligible) from a birth cohort had complete data for final analyses at age 4 years. Information about folic acid and other over‐the‐counter dietary supplements was obtained prospectively using interviewer‐administered questionnaires at the end of the first trimester of pregnancy. Psychological outcomes were assessed by two psychologists and teachers 4 years later. Low maternal socio‐economic status, smoking, high parity and short duration of breast feeding were associated with lower prevalence of folic acid supplement use. Verbal (b = 3.98, SE = 1.69), motor (b = 4.54, SE = 1.66) and verbal‐executive function (b = 3.97, SE = 1.68) scores, social competence (b = 3.97, SE = 1.61) and inattention symptom [OR = 0.46; 95% CI 0.22, 0.95] scores were associated with reported folic acid use. Reported folic acid supplement use during pregnancy was associated with improved neurodevelopment in children after adjusting for a number of sociodemographic and behavioural factors.

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  • There is wide evidence that pre and periconceptional folate supplementation supports neural and neurobehavioral development, bolstering social, cognitive and verbal functioning.

    “There is wide evidence that pre and periconceptional folate supplementation supports neural and neurobehavioral development, bolstering social, cognitive and verbal functioning [235–237].”

    From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [235]

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Authors
Julvez, J., Fortuny, J., Mendez, M., Torrent, M., Ribas‐Fitó, N., & Sunyer, J.
Affiliations
  • Universitat Pompeu Fabra (ES)
  • Center for Research in Environmental Epidemiology (ES)
ORCID
Venue
Paediatric and Perinatal Epidemiology
Publisher
Wiley
Published
2009-03-30
Volume
23
Issue
3
Pages
199-206
ISSN
  • 0269-5022 (ISSN-L)
  • 1365-3016
DOI
10.1111/j.1365-3016.2009.01032.x
OpenAlex
W1975127060
Cited by
150
References
34
Citations by year
2026: 4 · 2025: 7 · 2024: 11 · 2023: 10 · 2022: 9 · 2021: 14 · 2020: 6 · 2019: 13 · 2018: 9 · 2017: 10 · 2016: 10 · 2015: 11 · 2014: 8 · 2013: 5 · 2012: 11
FWCI
5.19
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Paediatric and Perinatal Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
Keywords
folic acid supplementation, pregnancy, child neurodevelopment, 4-year-old children, verbal ability, motor development, executive function, social competence, inattention, over-the-counter dietary supplements, maternal socioeconomic status, maternal smoking, parity, breastfeeding duration
MeSH terms
Child Development, Child, Preschool, Female, Folic Acid, Humans, Infant, Neural Tube Defects, Neurologic Examination, Pregnancy, Prenatal Care, Prenatal Exposure Delayed Effects, Socioeconomic Factors, Spain, Time Factors, Vitamins, Cohort Studies, Dietary Supplements, Prenatal Nutritional Physiological Phenomena

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