Effect of alcoholic beverages on postprandial glycemia and insulinemia in lean, young, healthy adults
Open accessAbstract
Background Ethanol's ability to inhibit gluconeogenesis might reduce postprandial glycemia in realistic meal settings.Objective The objective was to explore the effect of 3 types of alcoholic beverages consumed alone, with a meal, or 1 h before a meal on postprandial glycemia in healthy subjects.Design In study 1, isoenergetic (1000 kJ) servings of beer, white wine, and gin were compared with a 1000-kJ portion of white bread. In study 2, the same servings were compared with water as an accompaniment to a bread meal. In study 3, 20-g alcohol portions were served as a premeal drink. Fingertip capillary blood samples were taken at regular intervals over 2-3 h.Results In study 1, the mean (+/-SE) glucose scores for beer (58 +/- 11), wine (7 +/- 3), and gin (10 +/- 5) were significantly lower (P < 0.001) than those for bread (= 100). In study 2, meals consumed with beer (84 +/- 11; P = 0.03), wine (63 +/- 6; P < 0.001), and gin (80 +/- 12; P = 0.007) produced less glycemia than did the meal consumed with water (= 100). In study 3, all 3 beverages reduced the postprandial glycemic response to the subsequent meal (67 +/- 5, 75 +/- 6, and 78 +/- 4 with the beer, wine, and gin trials, respectively; P < 0.003).Conclusion In realistic settings, alcoholic beverage consumption lowers postprandial glycemia by 16-37%, which represents an unrecognized mechanism by which alcohol may reduce the risk of chronic disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Randomized placebo-controlled trials in healthy nondiabetic individuals showed that 1 to 2 drinks immediately before a meal significantly lower postprandial glucose and insulin levels.
“Randomized placebo-controlled trials in healthy nondiabetic individuals showed that 1 to 2 drinks immediately before a meal will significantly lower post-prandial glucose and insulin levels (37) (Fig. 7).”
From Dietary Strategies for Improving Post-Prandial Glucose, Lipids, Inflammation, and Cardiovascular Health (2008) · cites this paper as [37]
Study 3 reports significantly lower postprandial glucose after alcoholic drinks, but the drinks were consumed one hour before the meal, not immediately before it. The Study 3 results also say insulin responses tended to be higher, significantly so for gin, rather than significantly lower. The premeal servings were two standard drinks. (LLM, conf=0.93)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
International table of glycemic index and glycemic load values: 2002,
Foster-Powell, K., Holt, S. H., & Brand-Miller, J. C. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.1.5 · Cited by 3,080 · see citing works
Self-citationDiet, lifestyle, and the risk of type 2 diabetes mellitus in women.
Hu, F. B., Manson, J. E., Stampfer, M. J., Colditz, G., Liu, S., Solomon, C. G., & Willett, W. C. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010492 · Cited by 2,901 · see citing works
Rimm, E. B., Williams, P., Fosher, K., Criqui, M., & Stampfer, M. J. (1999) · BMJ · doi:10.1136/bmj.319.7224.1523 · Cited by 1,360 · see citing works
Frezza, M., di Padova, C., Pozzato, G., Terpin, M., Baraona, E., & Lieber, C. S. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001113220205 · Cited by 1,328 · see citing works
Davies, M. J., Baer, D. J., Judd, J. T., Brown, E. D., Campbell, W. S., & Taylor, P. R. (2002) · JAMA · doi:10.1001/jama.287.19.2559 · Cited by 459 · see citing works
Kiechl, S. J., Willeit, J., Poewe, W. H., Egger, G., Oberhollenzer, F., Muggeo, M., & Bonora, E. (1996) · BMJ · doi:10.1136/bmj.313.7064.1040 · Cited by 343 · see citing works
Light-to-Moderate Alcohol Intake Is Associated With Enhanced Insulin Sensitivity
Facchini, F., Chen, Y.-D. I., & Reaven, G. M. (1994) · Diabetes Care · doi:10.2337/diacare.17.2.115 · Cited by 324 · see citing works
High Blood Alcohol Levels in Women
(1990) · New England Journal of Medicine · doi:10.1056/nejm199007053230113 · Cited by 289 · see citing works
Liljeberg, H., Lönner, C., & Björck, I. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1503 · Cited by 235 · see citing works
Mayer, E. J., Newman, B. M., Quesenberry, C. P., FRIEDMAN, G. D., & Selby, J. V. (1993) · Circulation · doi:10.1161/01.cir.88.5.2190 · Cited by 193 · see citing works
The Effect of Evening Alcohol Consumption on Next-Morning Glucose Control in Type 1 Diabetes
Turner, B. C., Jenkins, E., Kerr, D., Sherwin, R. S., & Cavan, D. A. (2001) · Diabetes Care · doi:10.2337/diacare.24.11.1888 · Cited by 186 · see citing works
Bell, R. A., Mayer‐Davis, E. J., Martin, M. A., Agostino, R. B. D., & Haffner, S. M. (2000) · Diabetes Care · doi:10.2337/diacare.23.11.1630 · Cited by 170 · see citing works
The Inhibition of Gluconeogenesis Following Alcohol in Humans
Siler, S. Q., Neese, R. A., Christiansen, M. P., & Hellerstein, M. K. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.5.e897 · Cited by 141 · see citing works
Ellison, J. M., Stegmann, J. M., Colner, S. L., Michael, R. H., Sharma, M. K., Ervin, K. R., & Horwitz, D. L. (2002) · Diabetes Care · doi:10.2337/diacare.25.6.961 · Cited by 133 · see citing works
Ethanol Decreases Glucose Utilization In Healthy Man*
Yki‐Järvinen, H., & Nikkilä, E. A. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-61-5-941 · Cited by 126 · see citing works
LUNCHTIME GIN AND TONIC A CAUSE OF REACTIVE HYPOGLYCÆMIA
O’Keefe, S. J., & Marks, V. (1977) · The Lancet · doi:10.1016/s0140-6736(77)91321-6 · Cited by 98 · see citing works
Alcohol consumption and insulin resistance in young adults
Flanagan, Moore, Godsland, Cockington, Robinson, & Phillips (2000) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2000.00624.x · Cited by 91 · see citing works
Alcohol Consumption and Risk of Type 2 Diabetes Among Older Women
Beulens, J. W. J., Stolk, R. P., van der Schouw, Y. T., Grobbee, D. E., Hendriks, H., & Bots, M. L. (2005) · Diabetes Care · doi:10.2337/diacare.28.12.2933 · Cited by 84 · see citing works
Goude, D., Fagerberg, B., & Hulthe, J. (2002) · Clinical Science · doi:10.1042/cs1020345 · Cited by 83 · see citing works
Riedt, C. S., Schlussel, Y., Thun, N. L. V., Ambia‐Sobhan, H., Stahl, T. J., Field, M. P., Sherrell, R. M., & Shapses, S. A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.972 · Cited by 81 · see citing works
McMonagle, J. R., & Felig, P. (1975) · Metabolism · doi:10.1016/0026-0495(75)90142-0 · Cited by 78 · see citing works
Alcohol, Type of Alcohol, and All‐Cause and Coronary Heart Disease Mortality
Grønbæk, M. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02902.x · Cited by 67 · see citing works
Alcohol impairs insulin sensitivity in normal subjects.
Avogaro, A., Fontana, P., Valerio, A., et al. (1987) · PubMed · Cited by 40 · see citing works
Gin and Tonic and Reactive Hypoglycemia: What Is Important–the Gin, the Tonic, or Both?1
Flanagan, D., Wood, P. J., Sherwin, R., Debrah, K., & Kerr, D. E. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4622 · Cited by 33 · see citing works
Christiansen, C. F., Thomsen, C., Rasmussen, O., Glerup, H., Berthelsen, J. G., Hansen, C., Ørskov, H., & Hermansen, K. (1993) · PubMed · Cited by 32 · see citing works
Avogaro, A., Duner, E., Marescotti, C., Ferrara, D., Prato, S. D., Nosadini, R., & Tiengo, A. (1983) · Metabolism · doi:10.1016/0026-0495(83)90008-2 · Cited by 16 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Mathews C, van Holde K, Ahern K, eds. Biochemistry. In: Carbohydrate metabolism II: biosynthesis. Boston, MA: Addison Wesley Longman, Inc, 2000.
Cited by
Sorted by citations
O’Keefe, J. H., Gheewala, N. M., & O’Keefe, J. O. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.016 · Cited by 497 · see citing works
Impact of Diet Composition on Blood Glucose Regulation
Russell, W. R., Baka, A., Björck, I., Delzenne, N., Gao, D., Griffiths, H. R., Hadjilucas, E., Juvonen, K., Lahtinen, S., Lansink, M., et al. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.792772 · Cited by 255 · see citing works
Dietary Glycemic Index and Load and the Risk of Type 2 Diabetes: Assessment of Causal Relations
Livesey, G., Taylor, R., Livesey, H. F., Buyken, A. E., Jenkins, D. J. A., Augustin, L. S. A., Sievenpiper, J. L., Barclay, A. W., Liu, S., Wolever, T. M. S., et al. (2019) · Nutrients · doi:10.3390/nu11061436 · Cited by 163 · see citing works
Self-citation
- Authors
- Brand-Miller, J. C., Fatima, K., Middlemiss, C., Bare, M., Liu, V., Atkinson, F., & Petocz, P.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Brand-Miller, Jennie C
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 85
- Issue
- 6
- Pages
- 1545-1551
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2130624836
- Cited by
- 69
- References
- 26
- Citations by year
- 2026: 4 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 6
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Keywords
- alcoholic beverages, ethanol, postprandial blood glucose, insulin levels, beer, white wine, gin, meal timing, gluconeogenesis inhibition, healthy young adults
- MeSH terms
- Adult, Ethanol, Alcoholic Beverages, Blood Glucose, Dietary Carbohydrates, Female, Gluconeogenesis, Humans, Insulin, Male, Middle Aged, Postprandial Period
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
