Reduced postprandial cholecystokinin (CCK) secretion in patients with noninsulin-dependent diabetes mellitus: evidence for a role for CCK in regulating postprandial hyperglycemia.
Abstract
The plasma cholecystokinin (CCK) response to a test meal was studied in 16 control subjects and 15 patients with noninsulin-dependent diabetes mellitus (NIDDM). Basal CCK levels were approximately 1 pmol in both groups. However, after the test meal, plasma CCK levels were 2-fold greater in the controls when compared to the diabetics. In controls, CCK levels maximally increased by 5.6 +/- 0.8 pmol (mean +/- SEM) 10 min after feeding, whereas in the NIDDM patients this value was 1.9 +/- 0.6 pmol (P < 0.001). After the test meal, the normal subjects showed no postprandial rise in blood glucose, whereas the diabetic patient showed a rise of 2.6 +/- 0.7 mmol. To determine whether the decreased CCK levels may have been related to the postprandial hyperglycemia, 7 diabetic subjects were infused with CCK. With this CCK infusion, postprandial glucose levels did not rise. These data suggest, therefore: 1) a role for cholecystokinin in regulating postprandial hyperglycemia in man, 2) abnormalities in CCK secretion occur in NIDDM and may contribute to the hyperglycemia seen in this disease.
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Reduced CCK plasma levels in noninsulin-dependent diabetes mellitus cause postprandial hyperglycemia.
“The pivotal role of CCK in modulating glucose homeostasis is reflected in postprandial hyperglycemia, which is due to reduced CCK plasma levels in noninsulin-dependent diabetes mellitus.240”
From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [240]
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- Authors
- Rushakoff, R. A., Goldfine, I. D., Beccaria, L. J., Mathur, A., Brand, R. J., & Liddle, R. A.
- Affiliations
- University of California, San Francisco (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1993-02
- Volume
- 76
- Issue
- 2
- Pages
- 489-493
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2089449544
- Cited by
- 59
- References
- 21
- Citations by year
- 2026: 1 · 2025: 5 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1p01dk038985-01a1, 5r01dk027626-19)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK38626, DK-27626, P01-DK-38985)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- cholecystokinin, type 2 diabetes, postprandial hyperglycemia, plasma CCK levels, test meal, glucose regulation
- MeSH terms
- Adult, Aged, Blood Glucose, Cholecystokinin, Diabetes Mellitus, Type 2, Female, Food, Humans, Hyperglycemia, Insulin, Male, Middle Aged
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