CoChat
Sign Up
Cited by 332Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMenopause: Health Impacts and Treatments

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Is the Risk of Developing Alzheimer's Disease Greater for Women than for Men?

Hebert, Liesi E., Scherr, Paul A., McCann, Judith J., Beckett, Laurel A., Evans, Denis A.·2001·American Journal of Epidemiology
DOI 10.1093/aje/153.2.132
Open this paper in CoChat — free account

Abstract

A large proportion of people with Alzheimer's disease (AD) are women; however, it is not clear whether this is due to higher risk of disease or solely to the larger number of women alive at ages when AD is common. Beginning in 1982, two stratified random samples of people aged ≥65 years in East Boston, Massachusetts underwent detailed, structured clinical evaluation for prevalent (467 people) and incident (642 people from a cohort previously ascertained to be disease-free) probable AD. The prevalence sample was followed for mortality for up to 11 years (through December 1992). The age-specific incidence of AD did not differ significantly by sex (for men vs. women, odds ratio = 0.92; 95% confidence interval (CI): 0.51, 1.67). Controlled for age, prevalence also did not differ significantly by sex (for men vs. women, odds ratio = 1.29; 95% CI: 0.67, 2.48). The increase in risk of mortality due to AD did not vary by sex. The odds ratio for women with AD compared with women without AD was 2.07 (95% CI: 1.21, 3.56). For men, the odds ratio was 2.22 (95% CI: 1.02, 4.81). These findings suggest that the excess number of women with AD is due to the longer life expectancy of women rather than sex-specific risk factors for the disease.

Overview

Integrity signals

Registry

Crossref · 10.1093/aje/153.2.132

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 51 references

Cited by

Sorted by citations

See all 332

Related

Metadata

Authors
Hebert, L. E., Scherr, P. A., McCann, J. J., Beckett, L. A., & Evans, D. A.
Affiliations
  • Rush University Medical Center (US)
  • Centers for Disease Control and Prevention (US)
  • Rush University (US)
ORCID
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2001-01-15
Volume
153
Issue
2
Pages
132-136
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
DOI
10.1093/aje/153.2.132
OpenAlex
W2105835982
Cited by
331
References
51
Citations by year
2026: 6 · 2025: 19 · 2024: 19 · 2023: 11 · 2022: 23 · 2021: 12 · 2020: 18 · 2019: 19 · 2018: 16 · 2017: 18 · 2016: 15 · 2015: 14 · 2014: 12 · 2013: 14 · 2012: 15
FWCI
6.01
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ag005362-02, 5r29ag011862-05)
  • National Institute on Aging (AG 10161, P30AG010161, AG 05362, AG11862)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
Alzheimer's disease, sex differences, women, age-specific incidence, prevalence, mortality, life expectancy, older adults, sex-specific risk factors
MeSH terms
Aged, Alzheimer Disease, Boston, Female, Humans, Longevity, Male, Population Surveillance, Risk Factors, Sex Factors, Incidence, Prevalence, Logistic Models, Odds Ratio, Survival Analysis, Sex Distribution

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review