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Cited by 916Diabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic DiseasesDiet, Metabolism, and Disease

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Metabolic Syndrome and Development of Diabetes Mellitus: Application and Validation of Recently Suggested Definitions of the Metabolic Syndrome in a Prospective Cohort Study

Laaksonen, D. E.·2002·American Journal of Epidemiology
DOI 10.1093/aje/kwf145
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Abstract

The World Health Organization (WHO) and the National Cholesterol Education Program (NCEP) recently proposed definitions for the metabolic syndrome. Little is known of their validity, however. The authors assessed the sensitivity and specificity of the definitions of the metabolic syndrome for prevalent and incident diabetes mellitus in a Finnish population-based cohort of middle-aged men (n = 1,005) followed for 4 years since the late 1980s. Four definitions based on the WHO and NCEP recommendations were compared. All definitions identified persons at high risk for developing diabetes during the 4-year follow-up (odds ratios = 5.0-8.8). The WHO definition including waist-hip ratio > 0.90 or body mass index >or= 30 kg/m(2) was the most sensitive (0.83 and 0.67) and least specific (0.78 and 0.80) in detecting the 47 prevalent and 51 incident cases of diabetes. The NCEP definition in which adiposity was defined as waist girth > 102 cm detected only 61% of prevalent and 41% of incident diabetes, although it was the most specific (0.89 and 0.90). The WHO definition seems valid as judged by its relatively high sensitivity and specificity in predicting diabetes. The NCEP definition including waist > 102 cm also identifies persons at high risk for diabetes, but it is relatively insensitive in predicting diabetes.

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Metadata

Authors
Laaksonen, D. E.
Affiliations
University of Eastern Finland (FI)
Corresponding author
Laaksonen, D. E.
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2002-12-01
Volume
156
Issue
11
Pages
1070-1077
ISSN
0002-9262 (ISSN-L)
DOI
10.1093/aje/kwf145
OpenAlex
W2149040949
Cited by
916
References
32
Citations by year
2026: 7 · 2025: 7 · 2024: 9 · 2023: 19 · 2022: 17 · 2021: 19 · 2020: 11 · 2019: 18 · 2018: 16 · 2017: 26 · 2016: 25 · 2015: 26 · 2014: 38 · 2013: 29 · 2012: 40
FWCI
34.39
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Academy of Finland (2041022, 41471, 1041086)
  • National Heart, Lung, and Blood Institute (HL-44199, R01HL044199)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
metabolic syndrome, diabetes mellitus, diagnostic criteria validity, WHO definition, waist-to-hip ratio, waist circumference, body mass index, adiposity, sensitivity and specificity, new-onset diabetes, middle-aged men
MeSH terms
Adult, Body Constitution, Diabetes Mellitus, Type 2, Finland, Humans, Insulin Resistance, Male, Middle Aged, Prospective Studies, Sensitivity and Specificity, World Health Organization, Body Mass Index, Metabolic Syndrome

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