The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Systematic Review and Meta-Analysis of the Association between β2-Adrenoceptor Polymorphisms and Asthma: A HuGE Review
Abstract
A number of studies have investigated two common polymorphisms in the beta(2)-adrenoceptor gene, Arg/Gly16 and Gln/Glu27, in relation to asthma susceptibility. The authors performed a meta-analysis of each polymorphism, as well as haplotype analysis, for adult and pediatric populations separately, using published data, supplemented by additional data requested from the original authors. Individual analysis detected no effect of Arg/Gly16 in adults but did suggest a recessive protective effect of Gly16 for children, with an odds ratio of 0.71 (95% confidence interval (CI): 0.53, 0.96) compared with the other genotypes. Results for Gln/Glu27 in adults seem to indicate that heterozygotes are at decreased risk of asthma than either homozygote (odds ratio = 0.73, 95% CI: 0.62, 0.87), although the studies are heterogeneous; in children, the Glu/Glu genotype has a decreased risk of asthma (odds ratio = 0.60, 95% CI: 0.35, 0.99) compared with the other genotypes. Despite the proximity of these two polymorphic sites, the linkage disequilibrium coefficient of 0.41 was not high (p < 0.001). Haplotype analysis suggests that there may be an interaction between the two sites, with a lower risk of asthma associated with the Glu27 allele (compared with Gln27), and that this risk is modified by the allele at position 16.
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Cites
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Cited by
Meta-analysis of filaggrin polymorphisms in eczema and asthma: Robust risk factors in atopic disease
Rodríguez, E., Baurecht, H., Herberich, E., Wagenpfeil, S., Brown, S. J., Cordell, H. J., Irvine, A. D., & Weidinger, S. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.03.036 · Cited by 430
Gratacòs, M., González, J. R., Mercader, J. M., de Cid, R., Urretavizcaya, M., & Estivill, X. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.025 · Cited by 428
Hou, H., Wang, C., Sun, F., Zhao, L., Dun, A., & Sun, Z. (2015) · Inflammation Research · doi:10.1007/s00011-015-0850-9 · Cited by 55
Pan, Y.-Q., Qiao, L., Xue, X.-D., & Fu, J.-H. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.01.076 · Cited by 41
Wang, X.-B., Cui, N.-H., Yang, J., Qiu, X.-P., Gao, J.-J., Yang, N., & Zheng, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111406 · Cited by 15
Metadata
- Authors
- Thakkinstian, A., McEvoy, M., Minelli, C., Gibson, P., Hancox, B., Duffy, D., Thompson, J., Hall, I., Kaufman, J., Leung, T.-F., Helms, P. J., Hakonarson, H., Halpi, E., Navon, R., & Attia, J.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-08-01
- Volume
- 162
- Issue
- 3
- Pages
- 201-211
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2171151551
- Cited by
- 356
- References
- 40
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Thakkinstian, A., McEvoy, M., Minelli, C., Gibson, P., Hancox, B., Duffy, D., Thompson, J., Hall, I., Kaufman, J., Leung, T.-F., Helms, P. J., Hakonarson, H., Halpi, E., Navon, R., & Attia, J. (2005). Systematic Review and Meta-Analysis of the Association between β2-Adrenoceptor Polymorphisms and Asthma: A HuGE Review. American Journal of Epidemiology. https://doi.org/10.1093/aje/kwi184
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