The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Non-eosinophilic asthma: importance and possible mechanisms
Open accessAbstract
There is increasing evidence that inflammatory mechanisms other than eosinophilic inflammation may be involved in producing the final common pathway of enhanced bronchial reactivity and reversible airflow obstruction that characterises asthma. A review of the literature has shown that, at most, only 50% of asthma cases are attributable to eosinophilic airway inflammation. It is hypothesised that a major proportion of asthma is based on neutrophilic airway inflammation, possibly triggered by environmental exposure to bacterial endotoxin, particulate air pollution, and ozone, as well as viral infections. If there are indeed two (or more) subtypes of asthma, and if non-eosinophilic (neutrophil mediated) asthma is relatively common, this would have major consequences for the treatment and prevention of asthma since most treatment and prevention strategies are now almost entirely focused on allergic/eosinophilic asthma and allergen avoidance measures, respectively. It is therefore important to study the aetiology of asthma further, including the underlying inflammatory profiles.
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Cites
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Cited by
After asthma: redefining airways diseases
Pavord, I. D., Beasley, R., Agusti, A., Anderson, G. P., Bel, E., Brusselle, G., Cullinan, P., Custovic, A., Ducharme, F. M., Fahy, J. V., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)30879-6 · Cited by 1,073
Eosinophils: Biological Properties and Role in Health and Disease
HOGAN, S. P., ROSENBERG, H. F., MOQBEL, R., PHIPPS, S., FOSTER, P. S., LACY, P., KAY, A. B., & ROTHENBERG, M. E. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.02958.x · Cited by 834
Petsky, H. L., Cates, C. J., Lasserson, T. J., Li, A. M., Turner, C., Kynaston, J. A., & Chang, A. B. (2012) · Thorax · doi:10.1136/thx.2010.135574 · Cited by 338
Bel, E. H. (2004) · Current Opinion in Pulmonary Medicine · doi:10.1097/00063198-200401000-00008 · Cited by 293
Asthma in Children and Adults—What Are the Differences and What Can They Tell us About Asthma?
Trivedi, M., & Denton, E. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00256 · Cited by 283
Metadata
- Authors
- Douwes, J.
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2002-07-01
- Volume
- 57
- Issue
- 7
- Pages
- 643-648
- ISSN
- 0040-6376 (ISSN-L)
- OpenAlex
- W2097681404
- Cited by
- 640
- References
- 86
- FWCI
- 13.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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