Systematic Review: Why sources of heterogeneity in meta-analysis should be investigated

Meta-analysis in clinical trials

DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works

Practical Statistics for Medical Research.

Walter, S., & Altman, D. G. (1992) · Biometrics · doi:10.2307/2532320 · Cited by 11,665 · see citing works

Practical Statistics for Medical Research

Altman, D. G. (1990) · doi:10.1201/9780429258589 · Cited by 10,668 · see citing works

Practical Statistics for Medical Research.

Bartko, J. J., & Altman, D. G. (1992) · Journal of the American Statistical Association · doi:10.2307/2290246 · Cited by 4,834 · see citing works

Blood pressure, stroke, and coronary heart disease *1Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias

MACMAHON, S. (1990) · The Lancet · doi:10.1016/0140-6736(90)90878-9 · Cited by 4,253 · see citing works

COLLABORATIVE OVERVIEW OF RANDOMIZED TRIALS OF ANTIPLATELET THERAPY .1. PREVENTION OF DEATH, MYOCARDIAL-INFARCTION, AND STROKE BY PROLONGED ANTIPLATELET THERAPY IN VARIOUS CATEGORIES OF PATIENTS

Altman, R., Carreras, L., Díaz, R. S., Figueroa, E. B., Paolasso, E., Parodi, J. C., Cade, J. F., Donnan, G. A., Eadie, M. J., Gavaghan, T. P., et al. (1994) · Cited by 3,322 · see citing works

Publication bias in clinical research

Easterbrook, P. J., Gopalan, R., Berlin, J. A., & Matthews, D. R. (1991) · The Lancet · doi:10.1016/0140-6736(91)90201-y · Cited by 3,109 · see citing works

Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy

Early Breast Cancer Trialist's Collaborative Group (1992) · The Lancet · doi:10.1016/0140-6736(92)90997-h · Cited by 2,191 · see citing works

By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease?

Law, M., Wald, N., & Thompson, S. (1994) · British medical journal · doi:10.1136/bmj.308.6925.367 · Cited by 1,306 · see citing works

Analysis and interpretation of treatment effects in subgroups of patients in randomized clinical trials

Yusuf, S. (1991) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1991.03470010097038 · Cited by 1,014 · see citing works

A consumer's guide to subgroup analyses

Oxman, A. D., & Guyatt, G. H. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-1-78 · Cited by 914 · see citing works

Meta-analysis of the literature or of individual patient data: is there a difference?

Stewart, L. A., & Parmar, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)93004-k · Cited by 771 · see citing works

A general parametric approach to the meta‐analysis of randomized clinical trials

Whitehead, A., & Whitehead, J. (1991) · Statistics in Medicine · doi:10.1002/sim.4780101105 · Cited by 750 · see citing works

Nutritional supplementation, psychosocial stimulation, and mental development of stunted children: the Jamaican Study

Grantham-McGregor, S. M., Powell, C. A., Walker, S. P., & Himes, J. H. (1991) · The Lancet · doi:10.1016/0140-6736(91)90001-6 · Cited by 685 · see citing works

A note on graphical presentation of estimated odds ratios from several clinical trials

Galbraith, R. F. (1988) · Statistics in Medicine · doi:10.1002/sim.4780070807 · Cited by 663 · see citing works

Meta-analysis: State-of-the-Science

Dickersin, K., & Berlin, J. A. (1992) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036084 · Cited by 502 · see citing works

Can meta-analyses be trusted?

Thompson, S. G., & Pocock, S. (1991) · The Lancet · doi:10.1016/0140-6736(91)91975-z · Cited by 489 · see citing works

Cholesterol lowering and mortality: the importance of considering initial level of risk.

Smith, G., Song, F., & Sheldon, T. (1993) · British medical journal · doi:10.1136/bmj.306.6889.1367 · Cited by 447 · see citing works

Why do we need systematic overviews of randomized trials? (Transcript of an oral presentation, modified by the editors)

Peto, R. (1987) · Statistics in Medicine · doi:10.1002/sim.4780060306 · Cited by 409 · see citing works

Cholesterol and heart disease in older persons and women review of an NHLBI workshop

Manolio, T. A., Pearson, T. A., WENGER, N. K., Barrett-Connor, E. L., Payne, G. H., & Harlan, W. R. (1992) · Annals of Epidemiology · doi:10.1016/1047-2797(92)90051-q · Cited by 353 · see citing works

Prevention of First Bleeding in Cirrhosis

Pagliaro, L., D’Amico, G., Sørensen, T. I. A., Lebrec, D., Burroughs, A. K., Morabito, A., Tinè, F., Politi, F., & Traina, M. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-1-59 · Cited by 318 · see citing works

Cholesterol lowering trials in coronary heart disease: Frequency of citation and outcome.

Ravnskov, U. (1992) · BMJ · doi:10.1136/bmj.305.6844.15 · Cited by 313 · see citing works

Low serum cholesterol and the risk of cancer: an analysis of the published prospective studies

Law, M. R., & Thompson, S. G. (1991) · Cancer Causes & Control · doi:10.1007/bf00052142 · Cited by 119 · see citing works

Controversies in meta-analysis: the case of the trials of serum cholesterol reduction

Thompson, S. G. (1993) · Statistical Methods in Medical Research · doi:10.1177/096228029300200205 · Cited by 118 · see citing works

Does plasma cholesterol concentration predict mortality from coronary heart disease in elderly people? 18 year follow up in Whitehall study.

Shipley, M. J., Pocock, S., & Marmot, M. G. (1991) · BMJ · doi:10.1136/bmj.303.6794.89 · Cited by 114 · see citing works

Inter‐study differences: How should they influence the interpretation and analysis of results?

Bailey, K. R. (1987) · Statistics in Medicine · doi:10.1002/sim.4780060327 · Cited by 108 · see citing works

Importance of trends in the interpretation of an overall odds ratio in the meta‐analysis of clinical trials

Senn, S. J., & Brand, R. (1994) · Statistics in Medicine · doi:10.1002/sim.4780130310 · Cited by 91 · see citing works

Importance of trends in the interpretation of an overall odds ratio in the meta‐analysis of clinical trials

Brand, R., & Kragt, H. (1992) · Statistics in Medicine · doi:10.1002/sim.4780111605 · Cited by 64 · see citing works

Systemic Treatment of Early Breast Cancer by Hormonal, Cytotoxic, or Immune Therapy

&NA; (1992) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199206000-00018 · Cited by 54 · see citing works

The Impact of Stopping Rules on Heterogeneity of Results in Overviews of Clinical Trials

Hughes, M. D., Freedman, L. S., & Pocock, S. (1992) · Biometrics · doi:10.2307/2532737 · Cited by 35 · see citing works

Can meta-analyses be trusted?

Chalmers, I., Stewart, L., Girling, D. J., Parmar, M. B., & Machin, D. (1991) · The Lancet · doi:10.1016/0140-6736(91)92771-s · Cited by 34 · see citing works

Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement

Moher, D., Cook, D. J., Eastwood, S., Olkin, I., Rennie, D., & Stroup, D. F. (1999) · The Lancet · doi:10.1016/s0140-6736(99)04149-5 · Cited by 4,826 · see citing works

Systematic reviews in the social sciences: a practical guide

(2006) · Choice Reviews Online · doi:10.5860/choice.43-5664 · Cited by 4,074 · see citing works

Systematic reviews: CRD's guidance for undertaking reviews in health care

Tacconelli, E. (2010) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(10)70065-7 · Cited by 3,237 · see citing works

How should meta‐regression analyses be undertaken and interpreted?

Thompson, S. G., & Higgins, J. P. T. (2002) · Statistics in Medicine · doi:10.1002/sim.1187 · Cited by 3,026 · see citing works

Interpretation of random effects meta-analyses

Riley, R. D., Higgins, J. P. T., & Deeks, J. J. (2011) · BMJ · doi:10.1136/bmj.d549 · Cited by 2,884 · see citing works

The CONSORT statement: revised recommendations for improving the quality of reports of parallel group randomized trials

Moher, D., Schulz, K. F., & Altman, D. G. (2001) · BMC Medical Research Methodology · doi:10.1186/1471-2288-1-2 · Cited by 2,755 · see citing works

A Re-Evaluation of Random-Effects Meta-Analysis

Higgins, J. P. T., Thompson, S. G., & Spiegelhalter, D. J. (2009) · Journal of the Royal Statistical Society Series A: Statistics in Society · doi:10.1111/j.1467-985x.2008.00552.x · Cited by 2,569 · see citing works

Systematic Review and Meta-analysis

Garg, A. X., Hackam, D. G., & Tonelli, M. A. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.01430307 · Cited by 2,251 · see citing works

Writing narrative literature reviews for peer-reviewed journals: secrets of the trade

Green, B. N., Johnson, C. D., & Adams, A. (2006) · Journal of Chiropractic Medicine · doi:10.1016/s0899-3467(07)60142-6 · Cited by 2,224 · see citing works

Statistical Methods for Examining Heterogeneity and Combining Results from Several Studies in Meta‐Analysis

Deeks, J. J., Altman, D. G., & Bradburn, M. J. (2001) · Systematic Reviews in Health Care · doi:10.1002/9780470693926.ch15 · Cited by 2,163 · see citing works

Socioeconomic inequalities in depression: a meta-analysis

Lorant, V. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwf182 · Cited by 2,603 · see citing works

Advanced methods in meta‐analysis: multivariate approach and meta‐regression

van Houwelingen, H. C., Arends, L. R., & Stijnen, T. (2002) · Statistics in Medicine · doi:10.1002/sim.1040 · Cited by 1,574 · see citing works

Depression in heart failure

Rutledge, T., Reis, V. A., Linke, S. E., Greenberg, B. H., & Mills, P. J. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.06.055 · Cited by 1,513 · see citing works

Controlling the risk of spurious findings from meta-regression

Higgins, J. P. T., & Thompson, S. G. (2004) · Statistics in Medicine · doi:10.1002/sim.1752 · Cited by 1,267 · see citing works

Long-term mental health of war-refugees: a systematic literature review

Bogic, M., Njoku, A., & Priebe, S. (2015) · BMC International Health and Human Rights · doi:10.1186/s12914-015-0064-9 · Cited by 1,166 · see citing works

Guidelines for systematic review in Conservation and environmental management

PULLIN, A. S., & STEWART, G. B. (2006) · Conservation Biology · doi:10.1111/j.1523-1739.2006.00485.x · Cited by 1,137 · see citing works

Consistency and inconsistency in network meta-analysis: model estimation using multivariate meta-regression

White, I. R., Barrett, J. K., Jackson, D., & Higgins, J. P. T. (2012) · Research Synthesis Methods · doi:10.1002/jrsm.1045 · Cited by 1,114 · see citing works

Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation

Patsopoulos, N. A., Εvangelou, Ε., & Ioannidis, J. P. A. (2008) · International Journal of Epidemiology · doi:10.1093/ije/dyn065 · Cited by 1,147 · see citing works

Conducting systematic reviews of diagnostic studies: didactic guidelines

Devillé, W. L. J. M., Buntinx, F., Bouter, L. M., Montori, V. M., de Vet, H. C. W., van der Windt, D., & Bezemer, P. D. (2002) · BMC Medical Research Methodology · doi:10.1186/1471-2288-2-9 · Cited by 954 · see citing works

Much ado about nothing: a comparison of the performance of meta-analytical methods with rare events

Bradburn, M. J., Deeks, J. J., Berlin, J. A., & Russell Localio, A. (2007) · Statistics in Medicine · doi:10.1002/sim.2528 · Cited by 938 · see citing works

Systems to rate the strength of scientific evidence.

West, S. L., King, V., Carey, T. S., Lohr, K. N., Mckoy, N. A., Sutton, S. F., & Lux, L. J. (2002) · PubMed Central · Cited by 873 · see citing works

The Interpretation of Random-Effects Meta-Analysis in Decision Models

Ades, A. E., Lu, G., & Higgins, J. P. T. (2005) · Medical Decision Making · doi:10.1177/0272989x05282643 · Cited by 861 · see citing works

Alveolar bone dimensional changes of post‐extraction sockets in humans: a systematic review

van der Weijden, G. A., Dell'Acqua, F., & Slot, D. E. (2009) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2009.01482.x · Cited by 858 · see citing works

A diagnostic meta-analysis of the Patient Health Questionnaire-9 (PHQ-9) algorithm scoring method as a screen for depression

Manea, L., Gilbody, S., & McMillan, D. (2015) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2014.09.009 · Cited by 795 · see citing works

Statistical heterogeneity in systematic reviews of clinical trials: a critical appraisal of guidelines and practice

Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2002) · Journal of Health Services Research & Policy · doi:10.1258/1355819021927674 · Cited by 755 · see citing works

Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children

Goldenberg, J. Z., Ma, S. S., Saxton, J. D., Martzen, M. R., Vandvik, P. O., Thorlund, K., Guyatt, G. H., & Johnston, B. C. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006095.pub3 · Cited by 741 · see citing works

Effectiveness of acute postoperative pain management: I. Evidence from published data

Dolin, S. J., Cashman, J. N., & Bland, J. M. (2002) · British Journal of Anaesthesia · doi:10.1093/bja/89.3.409 · Cited by 737 · see citing works

League Tables and Their Limitations: Statistical Issues in Comparisons of Institutional Performance

Goldstein, H., & Spiegelhalter, D. J. (1996) · Journal of the Royal Statistical Society. Series A (Statistics in Society) · doi:10.2307/2983325 · Cited by 1,069 · see citing works

Guidance on the conduct of narrative synthesis in sytematic reviews

Popay, J., Roberts, H. M., Sowden, A. J., Petticrew, M. P., Arai, L., Rodgers, M., & Britten, N. (2006) · Cited by 690 · see citing works

Home Visits to Prevent Nursing Home Admission and Functional Decline in Elderly People: Systematic Review and Meta-regression Analysis

Stuck, A. E., Egger, M., Hammer, A., Minder, C. E., & Beck, J. C. (2002) · JAMA · doi:10.1001/jama.287.8.1022 · Cited by 675 · see citing works

Risk markers associated with challenging behaviours in people with intellectual disabilities: a meta-analytic study

McClintock, K., Hall, S., & Oliver, C. (2003) · Journal of Intellectual Disability Research · doi:10.1046/j.1365-2788.2003.00517.x · Cited by 675 · see citing works

Is network meta-analysis as valid as standard pairwise meta-analysis? It all depends on the distribution of effect modifiers

Jansen, J. P., & Naci, H. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-159 · Cited by 656 · see citing works

Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease

Troosters, T., Casaburi, R. H., Gosselink, R., & Decramer, M. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200408-1109so · Cited by 644 · see citing works

Evidence on the long-term effects of breastfeeding SYSTEMATIC REVIEWS AND META-ANALYSES

Horta, B. L. (2007) · Cited by 636 · see citing works

Collaborative systematic review of the randomised trials of organised inpatient (stroke unit) care after stroke

(1997) · BMJ · doi:10.1136/bmj.314.7088.1151 · Cited by 642 · see citing works

A method for meta-analysis of molecular association studies

Thakkinstian, A., McElduff, P., D’Este, C. A., Duffy, D. L., & Attia, J. (2004) · Statistics in Medicine · doi:10.1002/sim.2010 · Cited by 615 · see citing works

Traditional reviews, meta-analyses and pooled analyses in epidemiology

Blettner, M. (1999) · International Journal of Epidemiology · doi:10.1093/ije/28.1.1 · Cited by 591 · see citing works

Recent developments in meta‐analysis

Sutton, A. J., & Higgins, J. P. T. (2007) · Statistics in Medicine · doi:10.1002/sim.2934 · Cited by 583 · see citing works

Factors predisposing women to chronic pelvic pain: systematic review

Latthe, P. M., Mignini, L. E., Gray, R. G., Hills, R. K., & Khan, K. S. (2006) · BMJ · doi:10.1136/bmj.38748.697465.55 · Cited by 582 · see citing works

How to read a paper: Papers that summarise other papers (systematic reviews and meta-analyses)

Greenhalgh, T. (1997) · BMJ · doi:10.1136/bmj.315.7109.672 · Cited by 574 · see citing works

Bronchodilators for bronchiolitis

Gadomski, A., & Scribani, M. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001266.pub4 · Cited by 566 · see citing works

Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children

Goldenberg, J. Z., Yap, C., Lytvyn, L., Lo, C. K.-F., Beardsley, J., Mertz, D., & Johnston, B. C. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006095.pub4 · Cited by 550 · see citing works

Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Qstatistics

Bowden, J., Tierney, J. F., Copas, A. J., & Burdett, S. (2011) · BMC Medical Research Methodology · doi:10.1186/1471-2288-11-41 · Cited by 551 · see citing works

A meta-analytic investigation of the relationship between the psychological distress of cancer patients and their carers

Hodges, L. J., Humphris, G. M., & Macfarlane, G. (2005) · Social Science & Medicine · doi:10.1016/j.socscimed.2004.04.018 · Cited by 533 · see citing works

Comprehensive literature review and statistical considerations for microarray meta-analysis

Tseng, G. C., Ghosh, D., & Feingold, E. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr1265 · Cited by 527 · see citing works

Systematic review: Hygiene and health: systematic review of handwashing practices worldwide and update of health effects

Freeman, M. C., Stocks, M. E., Cumming, O., Jeandron, A., Higgins, J. P. T., Wolf, J., Prüss‐Ustün, A., Bonjour, S., Hunter, P. R., Fewtrell, L., et al. (2014) · Tropical Medicine & International Health · doi:10.1111/tmi.12339 · Cited by 524 · see citing works

Hormone Replacement Therapy and Prevention of Nonvertebral Fractures

Torgerson, D. J., & Bell-Syer, S. E. (2001) · JAMA · doi:10.1001/jama.285.22.2891 · Cited by 521 · see citing works

Pharmacotherapy for post traumatic stress disorder (PTSD)

Stein, D. J., Ipser, J. C., Seedat, S., Sager, C., & Amos, T. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002795.pub2 · Cited by 519 · see citing works

Extended-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of the randomised trials

Eikelboom, J. W., Quinlan, D. J., & Douketis, J. D. (2001) · The Lancet · doi:10.1016/s0140-6736(00)05249-1 · Cited by 512 · see citing works

The more you drink, the harder you fall: A systematic review and meta-analysis of how acute alcohol consumption and injury or collision risk increase together

Taylor, B., Irving, H. M., Kanteres, F., Room, R., Borges, G., Cherpitel, C., Greenfield, T., & Rehm, J. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.02.011 · Cited by 509 · see citing works

Is There Evidence That Palliative Care Teams Alter End-of-Life Experiences of Patients and Their Caregivers?

Higginson, I. J., Finlay, I. G., Goodwin, D. M., Hood, K., Edwards, A., Cook, A., Douglas, H.-R., & Normand, C. E. M. (2003) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(02)00599-7 · Cited by 504 · see citing works

Collaborative systematic review of the randomised trials of organised in-patient (stroke unit) care after stroke.

Asplund, K., Berman, P. H., Blomstrand, C., Dennis, M. S., Douglas, J. A., Erilä, T., Garraway, M. O., Hamrin, E., Hankey, G. J., Ilmavirta, M., et al. (1997) · Cited by 499 · see citing works

The impact of sleep amount and sleep quality on glycemic control in type 2 diabetes: a systematic review and meta-analysis

Lee, S. W. H., Ng, K. Y., & Chin, W. K. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.02.001 · Cited by 470 · see citing works

Systematic review: Assessing the impact of drinking water and sanitation on diarrhoeal disease in low‐ and middle‐income settings: systematic review and meta‐regression

Wolf, J., Prüss‐Ustün, A., Cumming, O., Bartram, J., Bonjour, S., Cairncross, S., Clasen, T., Colford, J. M., Curtis, V., De France, J., et al. (2014) · Tropical Medicine & International Health · doi:10.1111/tmi.12331 · Cited by 461 · see citing works

A graphical tool for locating inconsistency in network meta-analyses

Krahn, U., Binder, H., & König, J. (2013) · BMC Medical Research Methodology · doi:10.1186/1471-2288-13-35 · Cited by 458 · see citing works

Approaches to heterogeneity in meta‐analysis

Petitti, D. B. (2001) · Statistics in Medicine · doi:10.1002/sim.1091 · Cited by 469 · see citing works

Evidence Synthesis for Decision Making 3

Dias, S., Sutton, A. J., Welton, N. J., & Ades, A. E. (2013) · Medical Decision Making · doi:10.1177/0272989x13485157 · Cited by 468 · see citing works

Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation

Arrich, J., Holzer, M. S., Havel, C., Müllner, M., & Herkner, H. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004128.pub4 · Cited by 454 · see citing works

Exploring sources of heterogeneity in systematic reviews of diagnostic tests

Lijmer, J. G., Bossuyt, P. M., & Heisterkamp, S. H. (2002) · Statistics in Medicine · doi:10.1002/sim.1185 · Cited by 446 · see citing works

A systematic overview of the incidence of posterior capsule opacification

Schaumberg, D. A., Dana, M. R., Christen, W. G., & Glynn, R. J. (1998) · Ophthalmology · doi:10.1016/s0161-6420(98)97023-3 · Cited by 443 · see citing works

Diagnostic Performance of Multidetector CT Angiography for Assessment of Coronary Artery Disease: Meta-analysis

Vanhoenacker, P. K., Heijenbrok‐Kal, M. H., Heste, R. V., Decramer, I., Hoe, L. R. V., Wijns, W. C., & Hunink, M. G. M. (2007) · Radiology · doi:10.1148/radiol.2442061218 · Cited by 442 · see citing works

Understanding heterogeneity in meta-analysis: the role of meta-regression

Baker, W. L., Michael White, C., Cappelleri, J. C., Kluger, J., Coleman, C. I., & From the Health Outcomes, P. (2009) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2009.02168.x · Cited by 492 · see citing works

Impact of the Quality of Coronal Restoration versus the Quality of Root Canal Fillings on Success of Root Canal Treatment: A Systematic Review and Meta-analysis

Gillen, B. M., Looney, S. W., Gu, L.-S., Loushine, B. A., Weller, R. N., Loushine, R. J., Pashley, D. H., & Tay, F. R. (2011) · Journal of Endodontics · doi:10.1016/j.joen.2011.04.002 · Cited by 429 · see citing works

Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement

QUOROM Group, Moher, D., Cook, D. J., Eastwood, S., Olkin, I., Rennie, D., & Stroup, D. F. (2000) · British journal of surgery · doi:10.1046/j.1365-2168.2000.01610.x · Cited by 418 · see citing works

Confidence intervals for the amount of heterogeneity in meta‐analysis

Viechtbauer, W. (2006) · Statistics in Medicine · doi:10.1002/sim.2514 · Cited by 399 · see citing works

A comparison of summary patient-level covariates in meta-regression with individual patient data meta-analysis

Lambert, P. C., Sutton, A. J., Abrams, K. R., & Jones, D. R. (2002) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(01)00414-0 · Cited by 396 · see citing works

Portal hypertension and variceal bleeding: An AASLD single topic symposium†

Grace, N. D., Groszmann, R. J., García–Tsao, G., Burroughs, A. K., Pagliaro, L., Makuch, R., Bosch, J., Stiegmann, G. V., Henderson, M. J., de Franchis, R., et al. (1998) · Hepatology · doi:10.1002/hep.510280339 · Cited by 389 · see citing works

A guide to interpreting discordant systematic reviews.

Jadad, A., Cook, D. J., & Browman, G. P. (1997) · Europe PMC (PubMed Central) · Cited by 393 · see citing works

Meta-Analytic Review of the Risk Factors for Acute Otitis Media

Uhari, M., Mantysaari, K., & Niemelä, M. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/22.6.1079 · Cited by 388 · see citing works

Low-Molecular-Weight Heparin Compared with Intravenous Unfractionated Heparin for Treatment of Pulmonary Embolism

Quinlan, D. J., McQuillan, A., & Eikelboom, J. W. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-3-200402030-00008 · Cited by 384 · see citing works

Synthesis of genetic association studies for pertinent gene–disease associations requires appropriate methodological and statistical approaches

Zintzaras, E., & Lau, J. (2008) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2007.12.011 · Cited by 360 · see citing works

Efficacy of prophylactic nimodipine for delayed ischemic deficit after subarachnoid hemorrhage: a metaanalysis

Barker, F. G., & Ogilvy, C. S. (1996) · Journal of neurosurgery · doi:10.3171/jns.1996.84.3.0405 · Cited by 357 · see citing works

Systematic Review and Meta-Analysis of the Association between β2-Adrenoceptor Polymorphisms and Asthma: A HuGE Review

Thakkinstian, A., McEvoy, M., Minelli, C., Gibson, P. G., Hancox, B., Duffy, D. L., Thompson, J. R., Hall, I. P., Kaufman, J. D., Leung, T. F., et al. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi184 · Cited by 356 · see citing works

Alcohol and hypertension: gender differences in dose-response relationships determined through systematic review and meta-analysis

Taylor, B., Irving, H. M., Baliunas, D., Roerecke, M., Patra, J., Mohapatra, S., & Rehm, J. (2009) · Addiction · doi:10.1111/j.1360-0443.2009.02694.x · Cited by 346 · see citing works

Magnesium Intake and Risk of Type 2 Diabetes

Dong, J.-Y., Xun, P., He, K., & Qin, L. (2011) · Diabetes Care · doi:10.2337/dc11-0518 · Cited by 375 · see citing works

Clinical Outcomes of Therapeutic Agents That Block the Platelet Glycoprotein IIb/IIIa Integrin in Ischemic Heart Disease

Kong, D. F., Califf, R. M., Miller, D. P., Moliterno, D. J., White, H. D., Harrington, R. A., Tcheng, J. E., Lincoff, A. M., Hasselblad, V., & Topol, E. J. (1998) · Circulation · doi:10.1161/01.cir.98.25.2829 · Cited by 346 · see citing works

Selective serotonin re-uptake inhibitors (SSRIs) versus placebo for obsessive compulsive disorder (OCD)

Soomro, G. M., Altman, D. G., Rajagopal, S., & Oakley Browne, M. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001765.pub3 · Cited by 342 · see citing works

Reliable assessment of the effects of treatment on mortality and major morbidity, I: clinical trials

Collins, R., & MacMahon, S. W. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03651-5 · Cited by 337 · see citing works

The efficacy of silver alloy-coated urinary catheters in preventing urinary tract infection: a meta-analysis

Saint, S. K., Elmore, J. G., Sullivan, S. D., Emerson, S. S., & Koepsell, T. D. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(98)00240-x · Cited by 329 · see citing works

Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review

Raghunath, A. S., Hungin, A. P. S., Wooff, D., & Childs, S. (2003) · BMJ · doi:10.1136/bmj.326.7392.737 · Cited by 327 · see citing works

Bivariate Random Effects Meta-Analysis of ROC Curves

Arends, L. R., Hamza, T. H., van Houwelingen, H. C., Heijenbrok‐Kal, M. H., Hunink, M. G. M., & Stijnen, T. (2008) · Medical Decision Making · doi:10.1177/0272989x08319957 · Cited by 325 · see citing works

Drug eluting and bare metal stents in people with and without diabetes: collaborative network meta-analysis

Stettler, C., Allemann, S., Wandel, S., Kastrati, A., Morice, M. C., Schomig, A., Pfisterer, M. E., Stone, G. W., Leon, M. B., Lezo, J. S. D., et al. (2008) · BMJ · doi:10.1136/bmj.a1331 · Cited by 320 · see citing works

Prognosis for the co‐twin following single‐twin death: a systematic review

Ong, S., Zamora, J., Khan, K. S., & Kilby, M. D. (2006) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.01027.x · Cited by 317 · see citing works

Meta-analysis: Chondroitin for Osteoarthritis of the Knee or Hip

Reichenbach, S., Sterchi, R., Scherer, M., Trelle, S., Bürgi, E., Bürgi, U., Dieppe, P. A., & Jüni, P. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-8-200704170-00009 · Cited by 316 · see citing works

Neurofeedback with fMRI: A critical systematic review

Thibault, R. T., MacPherson, A., Lifshitz, M., Roth, R. R., & Raz, A. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.12.071 · Cited by 300 · see citing works

Meta-analyses of molecular association studies: Methodologic lessons for genetic epidemiology

Attia, J. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(03)00011-8 · Cited by 311 · see citing works

Impact of implant support for mandibular dentures on satisfaction, oral and general health‐related quality of life: a meta‐analysis of randomized‐controlled trials

Emami, E., Heydecke, G., Rompre, P. H., de Grandmont, P., & Feine, J. S. (2009) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2008.01693.x · Cited by 299 · see citing works

Impact of Pharmacist Care in the Management of Cardiovascular Disease Risk Factors

Santschi, V. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.399 · Cited by 298 · see citing works

Expected Value of Sample Information Calculations in Medical Decision Modeling

Ades, A. E., Lu, G., & Claxton, K. (2004) · Medical Decision Making · doi:10.1177/0272989x04263162 · Cited by 364 · see citing works

Systematic review of randomised controlled trials of psychological therapy for chronic pain in children and adolescents, with a subset meta-analysis of pain relief

Eccleston, C., Morley, S., Williams, A. C. D. C., Yorke, L., & Mastroyannopoulou, K. (2002) · Pain · doi:10.1016/s0304-3959(02)00072-6 · Cited by 295 · see citing works

Randomised trials of human albumin for adults with sepsis: systematic review and meta-analysis with trial sequential analysis of all-cause mortality

Patel, A., Laffan, M., Waheed, U., & Brett, S. J. (2014) · BMJ · doi:10.1136/bmj.g4561 · Cited by 289 · see citing works

Systematic reviews of the effectiveness of quality improvement strategies and programmes

Grimshaw, J. (2003) · BMJ Quality & Safety · doi:10.1136/qhc.12.4.298 · Cited by 290 · see citing works

Meta-analysis of Cohen’s kappa

Sun, S. (2011) · Health Services and Outcomes Research Methodology · doi:10.1007/s10742-011-0077-3 · Cited by 282 · see citing works

Multivariate Random-effects Meta-analysis

White, I. R. (2009) · The Stata Journal Promoting communications on statistics and Stata · doi:10.1177/1536867x0900900103 · Cited by 289 · see citing works

Evaluation of various estimators for standardized mean difference in meta‐analysis

Lin, L., & Aloe, A. M. (2021) · Statistics in Medicine · doi:10.1002/sim.8781 · Cited by 297 · see citing works

A systematic review of school-based smoking prevention trials with long-term follow-up

Wiehe, S. E., Garrison, M. M., Christakis, D. A., Ebel, B. E., & Rivara, F. P. (2005) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2004.12.003 · Cited by 286 · see citing works

Meta‐analysis of continuous outcomes combining individual patient data and aggregate data

Riley, R. D., Lambert, P. C., Staessen, J. A., Wang, J., Gueyffier, F., Thijs, L., & Boutitie, F. (2007) · Statistics in Medicine · doi:10.1002/sim.3165 · Cited by 280 · see citing works

Bayesian random effects meta-analysis of trials with binary outcomes: methods for the absolute risk difference and relative risk scales

Warn, D. E., Thompson, S. G., & Spiegelhalter, D. J. (2002) · Statistics in Medicine · doi:10.1002/sim.1189 · Cited by 277 · see citing works

Microalbuminuria, blood pressure and diabetic renal disease: origin and development of ideas

Mogensen, C. E. (1999) · Diabetologia · doi:10.1007/s001250051151 · Cited by 274 · see citing works

Systematic review of dietary intervention trials to lower blood total cholesterol in free-living subjects Commentary: Dietary change, cholesterol reduction, and the public health---what does meta-analysis add?

Tang, J., Armitage, J., Lancaster, T., Silagy, C. A., Fowler, G. H., Neil, H. A. W., Smith, G. D., & Ebrahim, S. B. J. (1998) · BMJ · doi:10.1136/bmj.316.7139.1213 · Cited by 276 · see citing works

Methods for Exploring Heterogeneity in Meta-Analysis

Song, F., Sheldon, T., Sutton, A. J., Abrams, K. R., & Jones, D. R. (2001) · Evaluation & the Health Professions · doi:10.1177/016327870102400203 · Cited by 253 · see citing works

Letter from the editor: Meta-analysis, study heterogeneity, and clinical significance

Elston, D. M. (2022) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2022.01.024

The Authors Say: ‘The Data Are Not So Robust because of Heterogeneity’ – So, How Should I Deal with This Systematic Review?

Sandercock, P. A. (2011) · Cerebrovascular Diseases · doi:10.1159/000326068 · Cited by 24 · see citing works

Assessing and Exploring Heterogeneity

Schulzke, S. M. (2021) · Springer eBooks · doi:10.1007/978-3-030-71921-0_3 · Cited by 27 · see citing works

On the importance of heterogeneity in meta-analysis

O’Keefe, S. J., & Strom, B. L. (2009) · Clinical Trials · doi:10.1177/1740774509344372 · Cited by 3 · see citing works