Cited by 199Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchGenetic Associations and Epidemiology

The DOI matches its Crossref record; 78 of the 79 references it cites were found in a registry or an index.

Large Meta-Analysis Establishes the ACE Insertion-Deletion Polymorphism as a Marker of Alzheimer's Disease

Open access

Lehmann, Donald J., Cortina-Borja, Mario, Warden, Donald R., Smith, A. David, Sleegers, Kristel, Prince, Jonathan A., van Duijn, Cornelia M., Kehoe, Patrick G.·2005·American Journal of Epidemiology

DOI 10.1093/aje/kwi202

Open this paper in CoChat — free account

Abstract

Apolipoprotein E epsilon4 (APOE*4) is the only fully established susceptibility allele for Alzheimer's disease. One of the most studied candidates is the insertion (I)/deletion (D) polymorphism (indel) of the gene for angiotensin I-converting enzyme (ACE). This study aimed to clarify its association with Alzheimer's disease. The meta-analysis included 39 samples, comprising 6,037 cases of Alzheimer's disease and 12,099 controls, using mainly primary data. Potential interactions with gender, age, ethnic group, and carrier status of the apolipoprotein E epsilon4 allele were all examined. D homozygotes were at reduced risk of Alzheimer's disease (odds ratio = 0.81, 95% confidence interval: 0.72, 0.90; corrected p = 0.0004); I homozygotes showed no association with Alzheimer's disease, while heterozygotes were at increased risk. Although there were clear differences among the three ethnic groups examined (North Europeans, South Caucasians, and East Asians), in all groups D homozygotes were at reduced risk. These results confirm the association of the angiotensin I-converting enzyme indel with Alzheimer's disease across diverse populations, although this is probably due to linkage disequilibrium with the true risk factor. Further, in North Europeans, both association and Hardy-Weinberg analysis suggested partial heterosis, that is, an increased risk for heterozygotes, due to a hidden interaction with another, as yet unknown, risk factor. This interaction warrants further investigation.

Integrity signals

Registry

Crossref · 10.1093/aje/kwi202

Cites

78 of 78 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
(1959) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/22.4.719 · Cited by 14,689
Gentleman R: R: A language for data analysis and graphics
Ihaka, R., & Gentleman, R. (1996) · Journal of Computational and Graphical Statistics · doi:10.1080/10618600.1996.10474713 · Cited by 11,747
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,168
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels
Rigat, B., Hubert, C., Alhenc-Gelas, F., Cambien, F., Corvol, P., & Soubrier, F. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114844 · Cited by 3,767
Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859
Diagnosis of Alzheimer's Disease
Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499

Show all 79 references

Research works printed but not linked: 1

Armitage P. Statistical methods in medical research. Oxford, United Kingdom: Blackwell Scientific Publications, 1983.

Sorted by citations

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Alzheimer Disease Genetics Consortium (ADGC), Kunkle, B. W., The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, P. A. E. R. F. A. D. C. (., Grenier-Boley, B., Sims, R., Bis, J. C., Damotte, V., Naj, A. C., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0358-2 · Cited by 2,946
Self-citation
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
Bertram, L., McQueen, M. B., Mullin, K., Blacker, D., & Tanzi, R. E. (2007) · Nature Genetics · doi:10.1038/ng1934 · Cited by 1,857
GWAS on family history of Alzheimer’s disease
Marioni, R. E., Harris, S. E., Zhang, Q., McRae, A. F., Hagenaars, S. P., Hill, W. D., Davies, G., Ritchie, C. W., Gale, C. R., Starr, J. M., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0150-6 · Cited by 564
Defining the relationship between hypertension, cognitive decline, and dementia: a review
Walker, K. A., Power, M. C., & Gottesman, R. F. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0724-3 · Cited by 394
SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ‐Degrading Enzymes in Alzheimer's Disease
Miners, J. S., Baig, S., Palmer, J. C., Palmer, L. E., Kehoe, P. G., & Love, S. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00132.x · Cited by 393
Self-citation
ACE polymorphisms.
Sayed-Tabatabaei, F., Oostra, B., Isaacs, A., van Duijn, C. V., & Witteman, J. (2006) · Circulation Research · doi:10.1161/01.res.0000223145.74217.e7 · Cited by 306
Amyloid β-Protein Is Degraded by Cellular Angiotensin-converting Enzyme (ACE) and Elevated by an ACE Inhibitor*
Hemming, M. L., & Selkoe, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508460200 · Cited by 344
Clearance of cerebral Aβ in Alzheimer’s disease: reassessing the role of microglia and monocytes
Zuroff, L. R., Daley, D. A., Black, K. L., & Koronyo‐Hamaoui, M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2463-7 · Cited by 292
The CNS renin-angiotensin system
Halbach, O. V. B. U., & Albrecht, D. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0190-8 · Cited by 251
The Worldwide Challenge of the Dementias: A Role for B Vitamins and Homocysteine?
Smith, A. D. (2008) · Food and Nutrition Bulletin · doi:10.1177/15648265080292s119 · Cited by 221
Self-citation
Angiotensin-converting enzyme 2 is reduced in Alzheimer’s disease in association with increasing amyloid-β and tau pathology
Kehoe, P. G., Wong, S., AL Mulhim, N., Palmer, L. E., & Miners, J. S. (2016) · Alzheimer's Research & Therapy · doi:10.1186/s13195-016-0217-7 · Cited by 203
Self-citation
Variants within the COL5A1 gene are associated with Achilles tendinopathy in two populations
September, A. V., Cook, J., Handley, C. J., van der Merwe, L., Schwellnus, M. P., & Collins, M. (2008) · British Journal of Sports Medicine · doi:10.1136/bjsm.2008.048793 · Cited by 199
Regulation of Steady-state β-Amyloid Levels in the Brain by Neprilysin and Endothelin-converting Enzyme but Not Angiotensin-converting Enzyme
Eckman, E. A., Adams, S. K., Troendle, F. J., Stodola, B. A., Kahn, M. A., Fauq, A. H., Xiao, H. D., Bernstein, K. E., & Eckman, C. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605827200 · Cited by 196
Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives
Cheng, Y., Tian, D., & Wang, Y.-J. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00195-1 · Cited by 197
Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer’s disease?
Nalivaeva, N. N., Beckett, C., Belyaev, N. D., & Turner, A. J. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07510.x · Cited by 169
Angiotensin-Converting Enzyme Converts Amyloid β-Protein 1–42 (Aβ 1–42 ) to Aβ 1–40 , and Its Inhibition Enhances Brain Aβ Deposition
Zou, K., Yamaguchi, H., Akatsu, H., Sakamoto, T., Ko, M.-H., Mizoguchi, K., Gong, J.-S., Yu, W., Yamamoto, T., Kosaka, K., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1549-07.2007 · Cited by 193
β ‐Amyloid Degradation and Alzheimer′s Disease
Wang, D.-S., Dickson, D. W., & Malter, J. S. (2006) · BioMed Research International · doi:10.1155/jbb/2006/58406 · Cited by 195
Is inhibition of the renin–angiotensin system a new treatment option for Alzheimer's disease?
Kehoe, P. G., & Wilcock, G. K. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70077-7 · Cited by 183
Self-citation
Angiotensin‐converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE‐1 to cerebral amyloid angiopathy
Miners, J., Ashby, E. L., van Helmond, Z., Chalmers, K., Palmer, L., Love, S., & Kehoe, P. (2008) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00885.x · Cited by 170
Self-citation
Angiotensins in Alzheimer's disease – friend or foe?
Kehoe, P. G., Miners, J. S., & Love, S. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.07.006 · Cited by 164
Self-citation
Angiotensin-converting enzyme levels and activity in Alzheimer's disease: differences in brain and CSF ACE and association with ACE1 genotypes.
(2009) · PubMed Central · Cited by 165
Self-citation
Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans
Logue, M. W., Schu, M., Vardarajan, B. N., Farrell, J., Bennett, D. A., Buxbaum, J. D., Byrd, G. S., Ertekin‐Taner, N., Evans, D., Foroud, T., et al. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.06.010 · Cited by 136
Decreased Expression and Activity of Neprilysin in Alzheimer Disease Are Associated With Cerebral Amyloid Angiopathy
Miners, J. S., Helmond, Z. V., Chalmers, K. A., Wilcock, G. K., Love, S., & Kehoe, P. G. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000240463.87886.9a · Cited by 156
Self-citation
The Coming of Age of the Angiotensin Hypothesis in Alzheimer’s Disease: Progress Toward Disease Prevention and Treatment?
Kehoe, P. G. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-171119 · Cited by 133
Self-citation
Genetic association studies in patients with traumatic brain injury
Dardiotis, E., Fountas, K. N., Dardioti, M., Xiromerisiou, G., Kapsalaki, E. Z., Τάσιου, Α., & Hadjigeorgiou, G. M. (2009) · Neurosurgical FOCUS · doi:10.3171/2009.10.focus09215 · Cited by 131
Prevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors
Fournier, A. E., Oprisiu, R., Sérot, J., Godefroy, O., Achard, J., Faure, S., Mazouz, H., Temmar, M., Albu, A., Bordet, R., et al. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.89 · Cited by 131
Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphic Variant as a Marker of Coronary Artery Disease A Meta-analysis
Zintzaras, E. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.10.1077 · Cited by 122
Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer’s-like cognitive decline
Bernstein, K. E., Koronyo, Y., Salumbides, B. C., Sheyn, J., Pelissier, L., Lopes, D. H. J., Shah, K. H., Bernstein, E. A., Fuchs, D.-T. S., Yu, J. J.-Y., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci66541 · Cited by 117
Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid β-protein metabolism in mouse models of Alzheimer disease
Hemming, M. L., Selkoe, D. J., & Farris, W. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.01.004 · Cited by 119
Pharmacogenomics in Alzheimer's Disease
Cacabelos, R. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-205-2_10 · Cited by 109
Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer’s disease: Past, present and future
Gouveia, F., Camins, A., Ettcheto, M., Bicker, J., Falcão, A. C., Cruz, M. T., & Fortuna, A. C. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101612 · Cited by 99
Gene therapy in Alzheimer’s disease – potential for disease modification
Nilsson, P., Iwata, N., Muramatsu, S., Tjernberg, L. O., Winblad, B. G., & Saido, T. C. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01038.x · Cited by 98
The effects of commonly prescribed drugs in patients with Alzheimer's disease on the rate of deterioration
Ellul, J., Archer, N. J., Foy, C. M. L., Poppe, M., Boothby, H., Nicholas, H., Brown, R. G., & Lovestone, S. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.104034 · Cited by 91
Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia
Gao, Y., Ó’Caoimh, R., Healy, L. O., Kerins, D. M., Eustace, J. A., Guyatt, G. H., Sammon, D., & Molloy, D. W. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-002881 · Cited by 89
Effects of Centrally Acting Angiotensin Converting Enzyme Inhibitors on Functional Decline in Patients with Alzheimer's Disease
Ó’Caoimh, R., Healy, L. O., Gao, Y., Svendrovski, A., Kerins, D. M., Eustace, J. A., Kehoe, P. G., Guyatt, G. H., & Molloy, D. W. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131694 · Cited by 82
Self-citation
The association of angiotensin-converting enzyme with biomarkers for Alzheimer’s disease
Jochemsen, H. M., Teunissen, C. E., Ashby, E. L., van der Flier, W. M., Jones, R. E., Geerlings, M. I., Scheltens, P., Kehoe, P. G., & Muller, M. (2014) · Alzheimer's Research & Therapy · doi:10.1186/alzrt257 · Cited by 77
Self-citation
Aβ42-to-Aβ40- and Angiotensin-converting Activities in Different Domains of Angiotensin-converting Enzyme
Zou, K., Maeda, T., Watanabe, A., Liu, J., Liu, S., Oba, R., Satoh, Y.-I., Komano, H., & Michikawa, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.011437 · Cited by 81
Insights into the pathogenesis and pathogenicity of cerebral amyloid angiopathy
Love, S. (2009) · Frontiers in bioscience · doi:10.2741/3567 · Cited by 78
Association of Polymorphisms in the Angiotensin-Converting Enzyme Gene with Alzheimer Disease in an Israeli Arab Community
Meng, Y., Baldwin, C. T., Bowirrat, A., Waraska, K., Inzelberg, R., Friedland, R. P., & Farrer, L. A. (2006) · The American Journal of Human Genetics · doi:10.1086/503687 · Cited by 72
The N-domain of angiotensin-converting enzyme specifically hydrolyzes the Arg-5-His-6 bond of Alzheimer's Abeta-(1-16) peptide and its isoAsp-7 analogue with different efficiency as evidenced by quantitative matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Toropygin, I., Kugaevskaya, E. V., Mirgorodskaya, O., Elisseeva, Y. E., Kozmin, Y., Popov, I., Nikolaev, E., Makarov, A., & Kozin, S. (2008) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3357 · Cited by 61
Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease
Koronyo‐Hamaoui, M., Sheyn, J., Hayden, E. Y., Li, S., Fuchs, D.-T. S., Regis, G. C., Lopes, D. H. J., Black, K. L., Bernstein, K. E., Teplow, D. B., et al. (2019) · Brain · doi:10.1093/brain/awz364 · Cited by 75
Puzzling role of genetic risk factors in human longevity: “risk alleles” as pro-longevity variants
Ukraintseva, S. V., Yashin, A. I., Arbeev, K. G., Kulminski, A. M., Akushevich, I. V., Wu, D., Joshi, G., Land, K. C., & Stallard, E. (2015) · Biogerontology · doi:10.1007/s10522-015-9600-1 · Cited by 68
Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project
Lehmann, D. J., Schuur, M., Warden, D. R., Hammond, N., Belbin, O., Kölsch, H., Lehmann, M. G., Wilcock, G. K., Brown, K. S., Kehoe, P. G., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.07.018 · Cited by 64
Self-citation
Angiotensin-converting enzyme gene variants are associated with both cortisol secretion and late-life depression
Ancelin, M., Carrière, I., Scali, J., Ritchie, K. A., Chaudieu, I., & Ryan, J. L. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.95 · Cited by 62
The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project
Combarros, O., Warden, D. R., Hammond, N., Cortina‐Borja, M., Belbin, O., Lehmann, M. G., Wilcock, G. K., Brown, K. S., Kehoe, P. G., Barber, R., et al. (2010) · BMC Medical Genetics · doi:10.1186/1471-2350-11-162 · Cited by 57
Self-citation
A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer's disease pathology in mice
Liu, S., Ando, F., Fujita, Y., Liu, J., Maeda, T., Shen, X., Kikuchi, K., Matsumoto, A., Yokomori, M., Tanabe, C., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006420 · Cited by 58
Angiotensin-I converting enzyme (ACE): structure, biological roles, and molecular basis for chloride ion dependence
Masuyer, G., Yates, C. J., Sturrock, E. D., & Acharya, K. R. (2014) · Biological Chemistry · doi:10.1515/hsz-2014-0157 · Cited by 55
Antihypertensive drugs and brain function: mechanisms underlying therapeutically beneficial and harmful neuropsychiatric effects
Carnovale, C., Perrotta, C., Baldelli, S., Cattaneo, D., Montrasio, C., Barbieri, S. S., Pompilio, G., Vantaggiato, C., Clementi, E., & Pozzi, M. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac110 · Cited by 62
Angiotensin Converting Enzyme Inhibitors and Cognitive and Functional Decline in Patients with Alzheimer's Disease: An Observational Study
Hajjar, I. M., Keown, M., Lewis, P., & Almor, A. (2008) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317507309803 · Cited by 54
Renin-Angiotensin System and Alzheimer’s Disease Pathophysiology: From the Potential Interactions to Therapeutic Perspectives
Ribeiro, V. T., de Souza, L. C., & Silva, A. C. S. E. (2019) · Protein and Peptide Letters · doi:10.2174/0929866527666191230103739 · Cited by 50
A Pilot Study of Gene/Gene and Gene/Environment Interactions in Alzheimer Disease
Ghebranious, N., Mukesh, B. N., Giampietro, P. F., Glurich, I., Mickel, S. F., Waring, S. C., & McCarty, C. A. (2010) · Clinical Medicine & Research · doi:10.3121/cmr.2010.894 · Cited by 49
Towards compendia of negative genetic association studies: an example for Alzheimer disease
Blomqvist, M. E.-L., Reynolds, C. A., Katzov, H., Feuk, L., Andreasen, N., Bogdanović, N., Blennow, K., Brookes, A. J., & Prince, J. A. (2005) · Human Genetics · doi:10.1007/s00439-005-0078-9 · Cited by 47
Self-citation
Effects of age, genes, and pulse pressure on executive functions in healthy adults
Raz, N., Dahle, C. L., Rodrigue, K. M., Kennedy, K. M., & Land, S. J. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.05.015 · Cited by 48
Aβ43 Is the Earliest-Depositing Aβ Species in APP Transgenic Mouse Brain and Is Converted to Aβ41 by Two Active Domains of ACE
Zou, K., Liu, J., Watanabe, A., Hiraga, S., Liu, S., Tanabe, C., Maeda, T., Terayama, Y., Takahashi, S., Michikawa, M., et al. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.01.053 · Cited by 48
Association between Chronic Blood Pressure Changes and Development of Alzheimer's Disease
Feldstein, C. A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120613 · Cited by 47
Can angiotensin-converting enzyme inhibitors impact cognitive decline in early stages of Alzheimer's disease? An overview of research evidence in the elderly patient population
Rygiel, K. (2016) · Journal of Postgraduate Medicine · doi:10.4103/0022-3859.188553 · Cited by 46
Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits
Program, T. V. M. V., Bone, W. P., Siewert, K. M., Jha, A., Klarin, D., Damrauer, S. M., Chang, K.-M., Tsao, P. S., Assimes, T. L., Ritchie, M. D., et al. (2021) · Alzheimer's Research & Therapy · doi:10.1186/s13195-021-00773-z · Cited by 41
“, the ALU insertion/deletion at the ACE locus) [32].”
Background
Aβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes
Miners, J. S., Palmer, J. C., Tayler, H. M., Palmer, L. E., Ashby, E. L., Kehoe, P. G., & Love, S. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00238 · Cited by 43
Self-citation
Two Opposing Functions of Angiotensin-Converting Enzyme (ACE) That Links Hypertension, Dementia, and Aging
Le, D. D., Brown, L., Malik, K., & Murakami, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413178 · Cited by 40
The Beneficial Role of Vitamin D in Alzheimer’s Disease
Lương, K. V. Q., & Nguyễn, L. (2011) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317511429321 · Cited by 40
Ancillary risk information and pharmacogenetic tests: social and policy implications
Henrikson, N. B., Burke, W., & Veenstra, D. L. (2007) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500457 · Cited by 40
Functional regulation of Alu element of human angiotensin-converting enzyme gene in neuron cells
Wu, S.-J., Hsieh, T., Kuo, M., Tsai, M.-L., Tsai, K.-L., Chen, C., & Yang, Y. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.01.003 · Cited by 40
An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3
Edwards, T. L., Pericak‐Vance, M. A., Gilbert, J. R., Haines, J. L., Martin, E. R., & Ritchie, M. D. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30899 · Cited by 39
Biobanking for Epidemiological Research and Public Health
Brand, A. M., & Probst-Hensch, N. M. (2007) · Pathobiology · doi:10.1159/000104450 · Cited by 37
The Rationale and Design of the Reducing Pathology in Alzheimer’s Disease through Angiotensin TaRgeting (RADAR) Trial
Kehoe, P. G., Blair, P. S., Howden, B., Thomas, D. L., Malone, I. B., Horwood, J., Clement, C., Selman, L. E., Baber, H., Lane, A., et al. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-170101 · Cited by 35
Self-citation
The Insertion Polymorphism in Angiotensin-Converting Enzyme Gene Associated With the APOE ε4 Allele Increases the Risk of Late-Onset Alzheimer Disease
Wang, B., Jin, F., Yang, Z., Lu, Z., Kan, R., Li, S., Zheng, C., & Wang, L. (2006) · Journal of Molecular Neuroscience · doi:10.1385/jmn:30:3:267 · Cited by 36
Angiotensins and Alzheimer's disease: a bench to bedside overview
Kehoe, P. G. (2009) · Alzheimer s Research & Therapy · doi:10.1186/alzrt3 · Cited by 34
Self-citation
Renin Angiotensin Aldosterone System Inhibition in Controlling Dementia-Related Cognitive Decline
Ó’Caoimh, R., Kehoe, P. G., & Molloy, D. W. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141284 · Cited by 35
Self-citation
Meta-analysis of genetic association with diagnosed Alzheimer’s disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing
Kunkle, B., Grenier-Boley, B., Sims, R., Bis, J., Naj, A., Boland, A., Vronskaya, M., van der Lee, S., Amlie-Wolf, A., Bellenguez, C., et al. (2018) · doi:10.1101/294629 · Cited by 35
Self-citation
Dopamine D2 Receptor Genotype (C957T) and Habitual Consumption of Sugars in a Free-Living Population of Men and Women
Eny, K. M., Corey, P., & El‐Sohemy, A. (2009) · Lifestyle Genomics · doi:10.1159/000276991 · Cited by 34
Genetic Influences on Alzheimer’s Disease: Evidence of Interactions Between the Genes APOE, APOC1 and ACE in a Sample Population from the South of Brazil
Lucatelli, J. F., Barros, A. C., da Silva, V. K., MACHADO, F. D. S., Constantin, P. C., Dias, A., Hutz, M. H., & de Andrade, F. M. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0481-7 · Cited by 34
The Role of Beta-Adrenergic Receptor Blockers in Alzheimer’s Disease
Lương, K. V. Q., & Nguyễn, L. (2013) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317513488924 · Cited by 32
Acute Myocardial Infarction and Risk of Cognitive Impairment and Dementia: A Review
Thong, E. H., Quek, J. W. E., Loo, J. H., Yun, C.-Y., Teo, Y. N., Teo, Y. H., Leow, A. S., Li, T. Y., Sharma, V. K., Tan, B. Y., et al. (2023) · Biology · doi:10.3390/biology12081154 · Cited by 31
Lower circulating levels of angiotensin-converting enzyme (ACE) in patients with schizophrenia
Mohite, S., de Campos-Carli, S. M., Rocha, N. P., Sharma, S., de Miranda, A. S., Barbosa, I. G., Salgado, J. V., Silva, A. C. S. E., & Teixeira, A. L. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.06.023 · Cited by 31
Power and Pitfalls of the Genome-Wide Association Study Approach to Identify Genes for Alzheimer’s Disease
Sherva, R., & Farrer, L. A. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0184-4 · Cited by 31
Kallikrein/K1, Kinins, and ACE/Kininase II in Homeostasis and in Disease Insight From Human and Experimental Genetic Studies, Therapeutic Implication
Alhenc‐Gelas, F., Bouby, N., & Girolami, J. (2019) · Frontiers in Medicine · doi:10.3389/fmed.2019.00136 · Cited by 30
Angiotensin‐converting enzymes as druggable features of psychiatric and neurodegenerative disorders
Santiago, T. C., Parra, L., Nani, J. V. S., Fidalgo, T. M., Bradshaw, N. J., & Hayashi, M. A. F. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15806 · Cited by 30
Angiotensin converting enzyme insertion/deletion polymorphism in sporadic and familial Alzheimer's disease and longevity
Nacmias, B., Bagnoli, S., Tedde, A., Cellini, E., Bessi, V., Guarnieri, B., Ortensi, L., Piacentini, S., Bracco, L., & Sorbi, S. (2006) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2006.10.011 · Cited by 30
Effect of chronic angiotensin converting enzyme inhibition on spatial memory and anxiety-like behaviours in rats
Jenkins, T. A., & Chai, S. Y. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.08.010 · Cited by 29
Decision tree analysis of genetic risk for clinically heterogeneous Alzheimer’s disease
Yokoyama, J. S., Bonham, L. W., Sears, R. L., Klein, E., Karydas, A., Kramer, J. H., Miller, B. L., & Coppola, G. (2015) · BMC Neurology · doi:10.1186/s12883-015-0304-6 · Cited by 28
Of mice and men: more neurobiology in dementia
Codita, A., Winblad, B. G., & Mohammed, A. H. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000245757.06374.6a · Cited by 29
Homogeneous Assay of rs4343, an ACE I/D Proxy, and an Analysis in the British Women’s Heart and Health Study (BWHHS)
Abdollahi, M. R., Huang, S., Rodrı́guez, S., Guthrie, P. A. I., Smith, G. D., Ebrahim, S. B. J., Lawlor, D. A., Day, I. N. M., & Gaunt, T. R. (2007) · Disease Markers · doi:10.1155/2008/813679 · Cited by 28
Alzheimer’s Disease Genetics: Review of Novel Loci Associated with Disease
Tábuas‐Pereira, M., Santana, I. J., Guerreiro, R. J., & Brás, J. (2020) · Current Genetic Medicine Reports · doi:10.1007/s40142-020-00182-y · Cited by 26
Angiotensin-Converting Enzyme as a Potential Target for Treatment of Alzheimer's Disease: Inhibition or Activation?
Zou, K., & Michikawa, M. (2008) · Reviews in the Neurosciences · doi:10.1515/revneuro.2008.19.4-5.203 · Cited by 27
Lipoproteins, Vascular-Related Genetic Factors, and Human Longevity
Panza, F., D’Introno, A., Capurso, C. A., Colacicco, A. M., Seripa, D., Pilotto, A., Santamato, A., Capurso, A., & Solfrizzi, V. (2007) · Rejuvenation Research · doi:10.1089/rej.2007.0537 · Cited by 27
Fine-Mapping Angiotensin-Converting Enzyme Gene: Separate QTLs Identified for Hypertension and for ACE Activity
Chung, C., Wang, R.-Y., Fann, C. S. J., Chen, J., Jong, Y.-S., Jou, Y., Yang, H., Kang, C.-S., Chen, C., Chang, H.-C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056119 · Cited by 26
An age effect on the association of common variants of ACE with Alzheimer's disease.
Helbecque, N., Codron, V., Cottel, D., & Amouyel, P. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.06.006 · Cited by 34
Deletion/Insertion Polymorphism of the Angiotensin‐Converting Enzyme Gene and White Matter Hyperintensities in Dementia: A Pilot Study
Purandare, N. B., Voshaar, R. C. O., Davidson, Y. S., Gibbons, L., Hardicre, J., Byrne, E. J., McCollum, C. N., Jackson, A., Burns, A. S., & Mann, D. M. A. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00841.x · Cited by 26
Higher activity of peripheral blood angiotensin-converting enzyme is associated with later-onset of Alzheimer's disease
Akatsu, H., Ogawa, N., Kanesaka, T., Hori, A., Yamamoto, T., Matsukawa, N., & Michikawa, M. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.09.030 · Cited by 24
Cognitive disorders in diabetic patients
Koekkoek, P. S., Rutten, G. E. H. M., & Biessels, G. J. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53480-4.00011-4 · Cited by 27
Predictive value of testing for multiple genetic variants in multifactorial diseases: implications for the discourse on ethical, legal and social issues
Janssens, A. C. J. W., & Khoury, M. J. (2006) · Italian Journal of Public Health · doi:10.2427/5915 · Cited by 23
Association between the Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor Gamma 2 and Inflammatory Bowel Disease: A Meta-Analysis
Zhang, Z., Yang, N., Zhao, G., Zhu, L., & Wang, L.-X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030551 · Cited by 22
Literature-related discovery: common factors for Parkinson’s Disease and Crohn’s Disease
Kostoff, R. N. (2014) · Scientometrics · doi:10.1007/s11192-014-1298-3 · Cited by 21
PSEN1 polymorphisms alter the rate of cognitive decline in sporadic Alzheimer's disease patients
Belbin, O., Beaumont, H., Warden, D. R., Smith, A. D., Kalsheker, N. A., & Morgan, K. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.02.013 · Cited by 21
Self-citation
Interaction of insulin and PPAR-α genes in Alzheimer’s disease: the Epistasis Project
Kölsch, H., Lehmann, D. J., Ibrahim‐Verbaas, C. A., Combarros, O., van Duijn, C. M., Hammond, N., Belbin, O., Cortina‐Borja, M., Lehmann, M. G., Aulchenko, Y. S., et al. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0732-4 · Cited by 22
Self-citation
Interleukin-1A −889C/T polymorphism and risk of Alzheimer’s disease: a meta-analysis based on 32 case–control studies
Qin, X. Y., Peng, Q., Zeng, Z., Chen, Z., Lin, L., Deng, Y., Huang, X., Xu, J., Wu, H., Huang, S., et al. (2012) · Journal of Neurology · doi:10.1007/s00415-011-6381-6 · Cited by 20
The ACE Insertion Deletion polymorphism relates to dementia by metabolic phenotype, APOEɛ4, and age of dementia onset
Gustafson, D., Melchior, L. C., Eriksson, E., Sundh, V., Blennow, K., & Skoog, I. G. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.07.015 · Cited by 20
Association of angiotensin-converting enzyme functional gene I/D polymorphism with amnestic mild cognitive impairment
Zhang, Z., Deng, L., Yu, H., Shi, Y., Bai, F., Xie, C., Yuan, Y., Jia, J., & Zhang, Z. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.02.074 · Cited by 19
ACE I/D polymorphism affects cognitive function and gray-matter volume in amnestic mild cognitive impairment
Zhang, Z., Deng, L., Bai, F., Shi, Y., Yu, H., Yuan, Y., Jiang, T., Jia, J., & Zhang, Z. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.032 · Cited by 19
Unknown face of known drugs – what else can we expect from angiotensin converting enzyme inhibitors?
Wzgarda, A., Kleszcz, R., Prokop-Piotrkowska, M., Regulska, K., Regulski, M., Paluszczak, J., & Stanisz, B. J. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.12.031 · Cited by 19

Authors: Lehmann, D. J., Cortina-Borja, M., Warden, D. R., Smith, A. D., Sleegers, K., Prince, J. A., van Duijn, C. M., & Kehoe, P. G.
Affiliations: University of Oxford (GB)
Corresponding author: Lehmann, Donald J.
ORCID: Smith, A. David
Sleegers, Kristel
Kehoe, Patrick G.
Venue: American Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 2005-08-15
Volume: 162
Issue: 4
Pages: 305-317
ISSN: 0002-9262 (ISSN-L)
1476-6256
DOI: 10.1093/aje/kwi202
OpenAlex: W2044936845
Cited by: 199
References: 79
Citations by year: 2026: 3 · 2025: 1 · 2024: 6 · 2023: 8 · 2022: 3 · 2021: 9 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 9 · 2016: 5 · 2015: 7 · 2014: 15 · 2013: 9 · 2012: 9
FWCI: 2.16
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
Locations: American Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
Bristol Research (University of Bristol) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
UCL Discovery (University College London) (submittedVersion)
Funders: Bristol-Myers Squibb
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: Alzheimer's disease, angiotensin-converting enzyme, ACE I/D polymorphism, APOE ε4, genetic susceptibility, genetic association, linkage disequilibrium, heterosis, ethnic differences, Hardy-Weinberg equilibrium, risk factors
MeSH terms: Aged, Alzheimer Disease, Apolipoproteins E, Ethnicity, Female, Humans, Hybrid Vigor, Peptidyl-Dipeptidase A, Male, Middle Aged, Polymorphism, Genetic, Confidence Intervals, Apolipoprotein E4

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Large Meta-Analysis Establishes the ACE Insertion-Deletion Polymorphism as a Marker of Alzheimer's Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks