Insulin-like growth factors and subsequent risk of mortality in the United States

Saydah, S.; Graubard, B.; Ballard-Barbash, R.; Berrigan, D.

doi:10.1093/aje/kwm124

Cited by 71Growth Hormone and Insulin-like Growth FactorsHormonal and reproductive studiesBirth, Development, and Health

Insulin-like growth factors and subsequent risk of mortality in the United States

Saydah, S., Graubard, B., Ballard-Barbash, R., Berrigan, D.·2007·American Journal of Epidemiology

DOI 10.1093/aje/kwm124

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Abstract

Although numerous studies have explored the relation of insulin-like growth factor (IGF)-I and IGF-binding protein (BP) 3 with cancer and cardiovascular disease, only two previous studies are known to have looked at the association of IGF-I and IGF-BP3 with risk of mortality. The objective of this US study was to examine the risk of all-cause, heart disease, and cancer mortality associated with IGF-I and IGF-BP3 levels using data from the Third National Health and Nutrition Examination Survey (NHANES III) and NHANES III Mortality Study (n = 6,061) (1988-2000). The authors constructed proportional hazards models with age as the time scale to determine the association of baseline IGF-I and IGF-BP3 levels with subsequent mortality. After adjustment for baseline measures, there was no increased risk of all-cause, heart disease, or cancer mortality for the lower quartiles of IGF-I compared with the highest quartile. The adjusted relative hazard of all-cause mortality for the lowest quartile of IGF-BP3 compared with the highest quartile was 1.57 (95% confidence interval: 0.98, 2.52), and the trend for risk was significant (p = 0.0364), but there was no increased risk of heart disease or cancer mortality. Results suggest that the association of IGF-I and IGF-BP3 with mortality may differ from associations with incidence of disease.

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Observational studies have reported inconsistent associations between IGF-1 and mortality.
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Original Contribution Insulin-like Growth Factors and Subsequent Risk of Mortality in the United States
Saydah, S., Graubard, B., Ballard-Barbash, R. R., & Berrigan, D. (2006)
Self-citation
Mortality and Serum Insulin-Like Growth Factor (IGF)-I and IGF Binding Protein 3 Concentrations
Friedrich, N., Haring, R., Nauck, M. A., Lüdemann, J., Rosskopf, D., Spilcke-Liss, E., Felix, S. B., Dörr, M., Brabant, G. E., Völzke, H., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2138 · Cited by 116 · see citing works
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Relationship between serum levels of insulin-like growth factors and subsequent risk of cancer mortality: Findings from a nested case–control study within the Japan Collaborative Cohort Study
Pham, T., Fujino, Y., Nakachi, K., Suzuki, K. A. O., Ito, Y., Watanabe, Y., Inaba, Y., Tajima, K., Tamakoshi, A., & Yoshimura, T. (2010) · Cancer Epidemiology · doi:10.1016/j.canep.2010.03.017 · Cited by 8 · see citing works
Decline in circulating insulin-like growth factors and mortality in older adults: cardiovascular health study all-stars study
Kaplan, R. C., Bùžková, P., Cappola, A. R., Strickler, H. D., McGinn, A. P., Mercer, L. D., Arnold, A. M., Pollak, M. N., & Newman, A. B. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2967 · Cited by 24 · see citing works

Authors: Saydah, S., Graubard, B., Ballard-Barbash, R., & Berrigan, D.
Affiliations: Centers for Disease Control and Prevention (US)
National Cancer Institute (US)
National Institutes of Health (US)
ORCID: Saydah, S.
Berrigan, D.
Venue: American Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 2007-06-21
Volume: 166
Issue: 5
Pages: 518-526
ISSN: 0002-9262 (ISSN-L)
1476-6256
DOI: 10.1093/aje/kwm124
OpenAlex: W2166839527
Cited by: 71
References: 36
Citations by year: 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 4
FWCI: 6.33
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
Funders: Centers for Disease Control and Prevention
National Cancer Institute
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords: insulin-like growth factor I, IGF binding protein-3, mortality, all-cause mortality, heart disease mortality, cancer mortality, NHANES III, biomarkers, cardiovascular disease, cancer risk
MeSH terms: Adolescent, Adult, Aged, Cardiovascular Diseases, Female, Humans, Male, Middle Aged, Mortality, Neoplasms, Nutrition Surveys, Prospective Studies, Risk Factors, Somatomedins, United States, Proportional Hazards Models

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Insulin-like growth factors and subsequent risk of mortality in the United States

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