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Cited by 640Growth Hormone and Insulin-like Growth FactorsDiabetes, Cardiovascular Risks, and LipoproteinsHormonal and reproductive studies

Low Serum Insulin-Like Growth Factor I Is Associated With Increased Risk of Ischemic Heart Disease: A Population-Based Case-Control Study

Juul, Anders, Scheike, Thomas, Davidsen, Michael, Gyllenborg, Jesper, Jørgensen, Torben·2002·Circulation
DOI 10.1161/01.cir.0000027563.44593.cc
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Abstract

BACKGROUND: Insulin-like growth factor I (IGF-I) has been suggested to be involved in the pathogenesis of atherosclerosis. We hypothesize that low IGF-I and high IGFBP-3 levels might be associated with increased risk of ischemic heart disease (IHD). METHODS AND RESULTS: We conducted a nested case-control study within a large prospective study on cardiovascular epidemiology (DAN-MONICA). We measured IGF-I and IGFBP-3 in serum from 231 individuals who had a diagnosis of IHD 7.63 years after blood sampling and among 374 control subjects matched for age, sex, and calendar time. At baseline when all individuals were free of disease, subjects in the low IGF-I quartile had significantly higher risk of IHD during the 15-year follow-up period, with a relative risk (RR) of 1.94 (95% CI, 1.03 to 3.66) of IHD compared with the high IGF-I quartile group, when IGFBP-3, body mass index, smoking, menopause, diabetes, and use of antihypertensives were controlled for. Conversely, individuals in the high IGFBP-3 quartile group had an adjusted RR of 2.16 (95% CI, 1.18 to 3.95) of having IHD. Identification of a high-risk population with low IGF-I and high IGFBP-3 levels resulted in markedly higher risk of IHD (RR 4.07; 95% CI, 1.48 to 11.22) compared with the index group. CONCLUSIONS: Individuals without IHD but with low circulating IGF-I levels and high IGFBP-3 levels have significantly increased risk of developing IHD during a 15-year follow-up period. Our findings suggest that IGF-I may be involved in the pathogenesis of IHD.

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  • Some studies have found that meat, as a protein source, is associated with higher serum levels of IGF-1, which in turn is related to increased bone mineralization and fewer fractures.

    “Some studies have found that meat, as a protein source, is associated with higher serum levels of IGF-1 [189], which in turn is related to increased bone mineralization and fewer fractures [190].”

    From International Society of Sports Nutrition Position Stand: protein and exercise (2017) · cites this paper as [190]

    The cited paper’s Measurements and Discussion sections concern serum IGF-I and ischemic heart disease. A search for meat, dietary protein, and IGF-I found no passage linking meat consumption to higher serum IGF-I. The bone-mineralization and fracture clause carries a different citation [190], so it is not assessed here. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • Low plasma levels of IGF1 predict development of type 2 diabetes and correlate with insulin resistance and increased risk of metabolic syndrome and cardiovascular disease.

    “There is evidence that low plasma levels of IGF1 predict the development of type 2 diabetes and correlate with insulin resistance and increased risk of metabolic syndrome and cardiovascular disease [[231], [232], [233]] (Table 1).”

    From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [233]

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Research works printed but not linked: 1

  1. Frystyk J, Skjaerbaek C, Vestbo E, et al. Circulating levels of free insulin-like growth factors in obese subjects: the impact of type 2 diabetes. Diabetes Metab Res Rev. 1999;15:314 -322.

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Authors
Juul, A., Scheike, T., Davidsen, M., Gyllenborg, J., & Jørgensen, T.
Affiliations
University of Copenhagen (DK)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-08-20
Volume
106
Issue
8
Pages
939-944
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.0000027563.44593.cc
OpenAlex
W2145397058
Cited by
640
References
26
Citations by year
2026: 6 · 2025: 9 · 2024: 12 · 2023: 13 · 2022: 17 · 2021: 21 · 2020: 21 · 2019: 16 · 2018: 21 · 2017: 24 · 2016: 21 · 2015: 21 · 2014: 30 · 2013: 24 · 2012: 31
FWCI
18.92
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
insulin-like growth factor I, IGFBP-3, ischemic heart disease, atherosclerosis, cardiovascular risk factors, serum biomarkers, IGF-1 deficiency, disease risk prediction
MeSH terms
Adult, Follow-Up Studies, Humans, Insulin-Like Growth Factor I, Middle Aged, Prospective Studies, Risk Factors, Case-Control Studies, Myocardial Ischemia, Insulin-Like Growth Factor Binding Protein 3

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