Cited by 121Acute Myocardial Infarction ResearchHealthcare Systems and Public HealthCardiovascular Health and Risk Factors

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Trend of Increase in the Incidence of Acute Myocardial Infarction in a Japanese Population: Takashima AMI Registry, 1990-2001

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Rumana, N., Kita, Y., Turin, T. C., Murakami, Y., Sugihara, H., Morita, Y., Tomioka, N., Okayama, A., Nakamura, Y., Abbott, R. D., Ueshima, H.·2008·American Journal of Epidemiology

DOI 10.1093/aje/kwn064

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Abstract

The incidence and mortality of acute myocardial infarction (AMI) remain low in Japan despite major dietary changes and worsening cardiovascular risk factors, a situation that should have resulted in a substantial increase in AMI rates (Japanese paradox). The current trend in the incidence of AMI was examined for the period 1990-2001 by use of data from the Takashima AMI Registry covering a stable population of approximately 55,000 in central Japan. AMI incidence rates (per 100,000 person-years) and 95% confidence intervals were calculated for 1990-1992, 1993-1995, 1996-1998, and 1999-2001. The incidence trend was determined by calculating the average annual change in percentage across the years. There were 352 (men: n = 224; women: n = 128) registered first-ever AMI cases during 1990-2001. The age-adjusted incidence rate of all AMI showed a gradual increase from 39.9 (95% confidence interval (CI): 29.8, 50.0) in 1990-1992 to 62.6 (95% CI: 51.5, 73.7) in 1999-2001. In men, the age-adjusted incidence rate increased from 66.5 (95% CI: 46.4, 86.6) in 1990-1992 to 100.7 (95% CI: 78.6, 122.7) in 1999-2001. In women, fluctuation was observed after an initial steep increase. The average annual incidence increased by 7.6% (95% CI: 3.5, 11.7) among men and by 8.3% (95% CI: 1.02, 15.6) among women. To the best of the authors' knowledge, this is the first study to report an increasing trend of AMI in a Japanese population.

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Authors: Rumana, N., Kita, Y., Turin, T. C., Murakami, Y., Sugihara, H., Morita, Y., Tomioka, N., Okayama, A., Nakamura, Y., Abbott, R. D., & Ueshima, H.
Affiliations: Shiga University of Medical Science (JP)
Otsu Red Cross Hospital (JP)
Kyoto Women's University (JP)
ORCID: Kita, Y.
Turin, T. C.
Sugihara, H.
Morita, Y.
Okayama, A.
Nakamura, Y.
Abbott, R. D.
Ueshima, H.
Venue: American Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 2008-03-25
Volume: 167
Issue: 11
Pages: 1358-1364
ISSN: 0002-9262 (ISSN-L)
1476-6256
DOI: 10.1093/aje/kwn064
OpenAlex: W2101922914
Cited by: 121
References: 29
Citations by year: 2025: 7 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 10 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 6 · 2014: 8 · 2013: 10 · 2012: 10
FWCI: 6.54
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: American Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
Institutional Repositories DataBase (IRDB) (submittedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords: acute myocardial infarction, incidence trends, age-adjusted incidence, sex differences in incidence, cardiovascular risk factors, dietary change, Japan
MeSH terms: Adult, Aged, Aged, 80 and over, Female, Humans, Japan, Male, Middle Aged, Myocardial Infarction, Registries, Incidence, Poisson Distribution, Linear Models

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Trend of Increase in the Incidence of Acute Myocardial Infarction in a Japanese Population: Takashima AMI Registry, 1990-2001

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