Relation Between Serum Total Cholesterol Level and Cardiovascular Disease Stratified by Sex and Age Group: A Pooled Analysis of 65 594 Individuals From 10 Cohort Studies in Japan
Open accessAbstract
Background: The relation between serum total cholesterol ( TC ) and cardiovascular disease in women and in the elderly is unclear, especially in A sian populations. Methods and Results: We examined this relation in the largest‐scale pooled analysis of the J apanese population, the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan ( EPOCH ‐ JAPAN ) study. A total of 65 594 participants who were 40 to 89 years of age and did not have a past history of cardiovascular disease were examined. C ox proportional‐hazards models were used to estimate hazard ratios for death from total stroke, cerebral infarction, intracranial cerebral hemorrhage, or coronary heart disease. The mean follow‐up period was 10.1 years, with the number of deaths from total stroke, cerebral infarction, cerebral hemorrhage, and coronary heart disease being 875, 457, 212, and 374, respectively. The participants were divided into 2 age groups: middle‐aged (40 to 69 years; mean age 55 years) and elderly (70 to 89 years; mean age 75 years). In men, the multivariate‐adjusted hazard ratios for coronary heart disease in the highest TC category (≥6.21 mmol/L) compared with the lowest category (<4.14 mmol/L) were 2.52 (95% confidence interval: 1.15–5.07) in middle‐aged participants and 2.77 (1.09–7.03) in elderly participants. In women, the hazard ratios of the highest TC category (≥6.72 mmol/L) compared with the lowest category (<4.66 mmol/L) were 3.20 (1.44–7.09) in middle‐aged participants and 1.02 (0.42–2.49) in elderly participants. TC levels were not associated with cerebral infarction in any age or sex group and were associated negatively with total stroke and cerebral hemorrhage. Conclusion: High serum TC levels are associated with coronary heart disease in middle‐aged J apanese men and women, but evidence in elderly J apanese individuals is still limited.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Low TC levels are associated with increased risk of hemorrhagic stroke.
“For hemorrhagic strokes, in contrast with the increase in risk of occurrence at low TC levels55–57)”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [55]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Shepherd, J., Blauw, G. J., Murphy, M. B., Bollen, E. L., Buckley, B. M., Cobbe, S. M., Ford, I., Gaw, A., Hyland, M., Jukema, J. W., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11600-x · Cited by 3,378 · see citing works
Rothman, K. J., Greenland, S. 1., & Lash, T. L. (1998) · Cited by 2,106 · see citing works
Incidence of and risk factors for atrial fibrillation in older adults
Psaty, B. M., Manolio, T. A., Kuller, L. H., Kronmal, R. A., Cushman, M., Fried, L. P., White, R., Furberg, C. D., & Rautaharju, P. M. (1997) · Circulation · doi:10.1161/01.cir.96.7.2455 · Cited by 1,462 · see citing works
Iso, H., Jacobs, D. R., Wentworth, D. N., Neaton, J. D., & Cohen, J. D. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201405 · Cited by 1,130 · see citing works
Self-citationNakamura, H., Arakawa, K., Itakura, H., Kitabatake, A., Goto, Y., Toyota, T., Nakaya, N., Nishimoto, S., Muranaka, M., Yamamoto, A., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69472-5 · Cited by 941 · see citing works
Cardiovascular Disease and Risk Factors in Asia
Ueshima, H., Sekikawa, A. M., Miura, K., Turin, T. C., Takashima, N., Kita, Y., Watanabe, M., Kadota, A., Okuda, N., Kadowaki, T., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.790048 · Cited by 923 · see citing works
Self-citationEpidemiology: Study Design and Data Analysis
(2006) · Technometrics · doi:10.1198/tech.2006.s407 · Cited by 789 · see citing works
Cholesterol, coronary heart disease, and stroke in the Asia Pacific region.
Asia Pacific Cohort Studies Collaboration (2003) · International Journal of Epidemiology · doi:10.1093/ije/dyg106 · Cited by 382 · see citing works
Tanizaki, Y., Kiyohara, Y., Kato, I., Iwamoto, H., Nakayama, K., Shinohara, N., Arima, H., Tanaka, K., Ibayashi, S., & Fujishima, M. (2000) · Stroke · doi:10.1161/01.str.31.11.2616 · Cited by 346 · see citing works
Stroke : a practical guide to management
Warlow, C. P., Dennis, M. S., van Gijn, J., Hankey, G. J., & Barnett, H. J. M. (2001) · UWA Profiles and Research Repository (UWA) · Cited by 301 · see citing works
Teramoto, T., Sasaki, J., Ueshima, H., Egusa, G., Kinoshita, M., Shimamoto, K., Daida, H., Biro, S., Hirobe, K., Funahashi, T., et al. (2007) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.14.45 · Cited by 265 · see citing works
Self-citationGlynn, R. J., Koenig, W., Nordestgaard, B. G., Shepherd, J., & Ridker, P. M. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-8-201004200-00005 · Cited by 252 · see citing works
Imamura, T., Doi, Y., Arima, H., Yonemoto, K., Hata, J., Kubo, M., Tanizaki, Y., Ibayashi, S., Iida, M., & Kiyohara, Y. (2009) · Stroke · doi:10.1161/strokeaha.108.529537 · Cited by 235 · see citing works
NIPPON DATA80 Research Group (2006) · Circulation Journal · doi:10.1253/circj.70.1249 · Cited by 218 · see citing works
A 15.5-Year Follow-up Study of Stroke in a Japanese Provincial City
Nakayama, T., Date, C., Yokoyama, A., Yoshiike, N., Yamaguchi, M., & Tanaka, H. (1997) · Stroke · doi:10.1161/01.str.28.1.45 · Cited by 203 · see citing works
Ebrahim, S. B. J., Sung, J., Song, Y., Ferrer, R. L., Lawlor, D. A., & Smith, G. D. (2006) · BMJ · doi:10.1136/bmj.38855.610324.80 · Cited by 187 · see citing works
Epidemiology: Study Design and Data Analysis (2nd ed.)
Davies, S. (2006) · Quarterly Publications of the American Statistical Association · Cited by 172 · see citing works
Okamura, T., Tanaka, H., Miyamatsu, N., Hayakawa, T., Kadowaki, T., Kita, Y., Nakamura, Y., Okayama, A., & Ueshima, H. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.01.024 · Cited by 172 · see citing works
Self-citationKitamura, A., Sato, S., Kiyama, M., Imano, H., Iso, H., Okada, T., Ohira, T., Tanigawa, T., Yamagishi, K., Nakamura, M., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.075 · Cited by 170 · see citing works
Self-citationNoda, H., Iso, H., Irie, F., Sairenchi, T., Ohtaka, E., Doi, M., Izumi, Y., & Ohta, H. (2009) · Circulation · doi:10.1161/circulationaha.108.795666 · Cited by 150 · see citing works
Self-citationUeshima, H., Iida, M., Shimamoto, T., Konishi, M., Tsujioka, K., Tanigaki, M., Nakanishi, N., Ozawa, H., Kojima, S., & Komachi, Y. (1980) · Preventive Medicine · doi:10.1016/0091-7435(80)90017-1 · Cited by 143 · see citing works
Self-citationEpidemiology: Study Design and Data Analysis
Davies, S. (2006) · Journal of the American Statistical Association · doi:10.1198/jasa.2006.s92 · Cited by 138 · see citing works
Risk Factors and 20-Year Stroke Mortality in Men and Women in the Renfrew/Paisley Study in Scotland
Hart, C., Hole, D. J., & Smith, G. D. (1999) · Stroke · doi:10.1161/01.str.30.10.1999 · Cited by 132 · see citing works
Rumana, N., Kita, Y., Turin, T. C., Murakami, Y., Sugihara, H., Morita, Y., Tomioka, N., Okayama, A., Nakamura, Y., Abbott, R. D., et al. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn064 · Cited by 121 · see citing works
Self-citationTanabe, N., Iso, H., Okada, K., Nakamura, Y., Harada, A., Ohashi, Y., Ando, T., Ueshima, H., & The Japan Arteriosclerosis Longitudinal Study Group (2010) · Circulation Journal · doi:10.1253/circj.cj-09-0861 · Cited by 99 · see citing works
Self-citationCui, R., Iso, H., Toyoshima, H., Date, C., Yamamoto, A., Kikuchi, S., Kondo, T., Watanabe, Y., Koizumi, A., Inaba, Y., et al. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.08.022 · Cited by 96 · see citing works
Self-citationChanges in Coronary Heart Disease Risk Among Japanese
Iso, H. (2008) · Circulation · doi:10.1161/circulationaha.107.750117 · Cited by 96 · see citing works
Self-citationAsia Pacific Cohort Studies Collaboration (2005) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000170264.84820.8e · Cited by 93 · see citing works
Nichaman, M. Z., Hamilton, H. B., Kagan, A., GRIER, T., Sacks, S. T., & Syme, S. L. (1975) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112187 · Cited by 84 · see citing works
Kitamura, A., Nakagawa, Y., Sato, M., Iso, H., Sato, S., Imano, H., Kiyama, M., Okada, T., Okada, H., Iida, M., et al. (2006) · Stroke · doi:10.1161/01.str.0000221714.96986.5f · Cited by 81 · see citing works
Self-citationYokota, C., Minematsu, K., Hasegawa, Y., & Yamaguchi, T. (2004) · Cerebrovascular Diseases · doi:10.1159/000079258 · Cited by 78 · see citing works
Stroke: A Practical Guide to Management
Jellinger, K. A. (2001) · European Journal of Neurology · doi:10.1046/j.1468-1331.2001.0222e.x · Cited by 77 · see citing works
Ischemic Stroke Subtypes in a Japanese Population
Turin, T. C., Kita, Y., Rumana, N., Nakamura, Y., Takashima, N., Ichikawa, M., Sugihara, H., Morita, Y., Hirose, K., Okayama, A., et al. (2010) · Stroke · doi:10.1161/strokeaha.110.581033 · Cited by 77 · see citing works
Self-citationMurakami, Y., Miura, K., Okamura, T., & Ueshima, H. (2010) · Preventive Medicine · doi:10.1016/j.ypmed.2010.11.009 · Cited by 43 · see citing works
Self-citationLow Serum Cholesterol Level and Increased Ischemic Stroke Mortality
Tsuji, H. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.255 · Cited by 16 · see citing works
What Caused This Transient or Persisting Ischaemic Event?
Warlow, C. P., van Gijn, J., Dennis, M. S., Wardlaw, J. M., Bamford, J., Hankey, G. J., Sandercock, P. A., Rinkel, G. J. E., Langhorne, P., Sudlow, C. L. M., et al. (2008) · Stroke · doi:10.1002/9780470696361.ch6 · Cited by 7 · see citing works
[Hyperlipidemia and arteriosclerosis].
Mabuchi, H. (1998) · PubMed · Cited by 6 · see citing works
Hyperlipemia and arteriosclerosis.
宏, 馬. (1998) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.87.950 · Cited by 4 · see citing works
Flagged first, then by citations
1 of the 40 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [34]Takayama Y Effects of an atherogenic diet on arterial lesions of hypertensive rats. J Jpn Coll Angiol. 1975; 15: 455- 464.
Cited by
Sorted by citations
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
Self-citationOkamura, T., Tsukamoto, K., Arai, H., Fujioka, Y., Ishigaki, Y., Koba, S., Ohmura, H., Shoji, T., Yokote, K., Yoshida, H., et al. (2023) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2022 · Cited by 317 · see citing works
Self-citationPeters, S. A. E., Singhateh, Y., MacKay, D., Huxley, R., & Woodward, M. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.03.016 · Cited by 278 · see citing works
Nishimura, K., Okamura, T., Watanabe, M., Nakai, M., Takegami, M., Higashiyama, A., Kokubo, Y., Okayama, A., & Miyamoto, Y. (2014) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.19356 · Cited by 228 · see citing works
Self-citation2017 Taiwan lipid guidelines for high risk patients
Li, Y., Ueng, K., Jeng, J., Charng, M., Lin, T., Chien, K., Wang, C., Chao, T., Liu, P., Su, C., et al. (2017) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2016.11.013 · Cited by 165 · see citing works
Beyond Lipid-Lowering: Effects of Statins on Cardiovascular and Cerebrovascular Diseases and Cancer
Morofuji, Y., Nakagawa, S., Ujifuku, K., Fujimoto, T., Otsuka, K., Niwa, M., & Tsutsumi, K. (2022) · Pharmaceuticals · doi:10.3390/ph15020151 · Cited by 152 · see citing works
Association of Lipids With Ischemic and Hemorrhagic Stroke
Gu, X., Li, Y., Chen, S., Yang, X., Liu, F., Li, Y., Li, J., Cao, J., Liu, X., Chen, J., et al. (2019) · Stroke · doi:10.1161/strokeaha.119.026402 · Cited by 150 · see citing works
Serum Uric Acid and Mortality Form Cardiovascular Disease: EPOCH-JAPAN Study
Zhang, W., Iso, H., Murakami, Y., Miura, K., Nagai, M., Sugiyama, D., Ueshima, H., Okamura, T., & EPOCH-JAPAN GROUP (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.31591 · Cited by 127 · see citing works
Self-citationDutheil, F., Baker, J. S., Mermillod, M., Cesare, M. D., Vidal, A., Moustafa, F., Pereira, B., & Navel, V. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.08.015 · Cited by 102 · see citing works
JCS 2018 Guideline on Diagnosis of Chronic Coronary Heart Diseases
Yamagishi, M., Tamaki, N., Akasaka, T., Ikeda, T., Ueshima, K., Uemura, S., Otsuji, Y., Kihara, Y., Kimura, K., Kimura, T., et al. (2021) · Circulation Journal · doi:10.1253/circj.cj-19-1131 · Cited by 99 · see citing works
Self-citationEffects of smoking and alcohol consumption on lipid profile in male adults in northwest rural China
Li, X., Zhao, Y., Huang, L. X., Xu, H., Liu, X. Y., Yang, J., Zhang, P. J., & Zhang, Y. (2018) · Public Health · doi:10.1016/j.puhe.2018.01.003 · Cited by 85 · see citing works
Asayama, K., Satoh, M., Murakami, Y., Ohkubo, T., NAGASAWA, S., Tsuji, I., Nakayama, T., Okayama, A., Miura, K., Imai, Y., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.03206 · Cited by 71 · see citing works
Self-citationObesity and Dyslipidemia in Chinese Adults: A Cross-Sectional Study in Shanghai, China
Zhu, J., Zhang, Y., Wu, Y., Xiang, Y., Tong, X., Yu, Y., Qiu, Y., Cui, S., Zhao, Q., Wang, N., et al. (2022) · Nutrients · doi:10.3390/nu14112321 · Cited by 68 · see citing works
LOX-1 in atherosclerotic disease
Sawamura, T., Wakabayashi, I., & Okamura, T. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.11.016 · Cited by 55 · see citing works
Self-citationChang, Y., Choi, J. E., Kim, S. W., Baek, S., & Cho, Y. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-012628 · Cited by 55 · see citing works
Satoh, M., Ohkubo, T., Asayama, K., Murakami, Y., Sakurai, M., Nakagawa, H., Iso, H., Okayama, A., Miura, K., Imai, Y., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.04639 · Cited by 54 · see citing works
Self-citationon behalf of the Japan Arteriosclerosis Longitudinal Study Group, Harada, A., Ueshima, H., Kinoshita, Y., Miura, K., Ohkubo, T., Asayama, K., & Ohashi, Y. (2019) · Hypertension Research · doi:10.1038/s41440-019-0220-z · Cited by 53 · see citing works
Self-citationJCS 2023 Guideline on the Primary Prevention of Coronary Artery Disease
Fujiyoshi, A., Kohsaka, S., Hata, J., Hara, M., Kai, H., Masuda, D., Miyamatsu, N., Nishio, Y., Ogura, M., Sata, M., et al. (2024) · Circulation Journal · doi:10.1253/circj.cj-23-0285 · Cited by 47 · see citing works
Self-citationFryer, L. G. D., Jones, B., Duncan, E. J., Hutchison, C. E., Ozkan, T., Williams, P. A., Alder, O., Nieuwdorp, M., Townley, A. K., Mensenkamp, A. R., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.479980 · Cited by 46 · see citing works
The Association Between Perfluoroalkyl Substances and Lipids in Cord Blood
Spratlen, M. J., Perera, F. P., Lederman, S. A., Robinson, M., Kannan, K., Herbstman, J. B., & Trasande, L. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz024 · Cited by 43 · see citing works
Association of change in total cholesterol level with mortality: A population-based study
Jeong, S., Choi, S., Kim, K., Kim, S., Lee, G., Son, J. S., Yun, J., & Park, S. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196030 · Cited by 36 · see citing works
Hirakawa, Y., Ninomiya, T., Kiyohara, Y., Murakami, Y., Saitoh, S., Nakagawa, H., Okayama, A., Tamakoshi, A., Sakata, K., Miura, K., et al. (2017) · Journal of Epidemiology · doi:10.1016/j.je.2016.04.001 · Cited by 34 · see citing works
Self-citationNantsupawat, N., Booncharoen, A., Wisetborisut, A., Jiraporncharoen, W., Pinyopornpanish, K., Chutarattanakul, L., & Angkurawaranon, C. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-0975-x · Cited by 34 · see citing works
Maruyama, S., Ebisawa, S., Miura, T., Yui, H., Kashiwagi, D., Nagae, A., Sakai, T., Kato, T., Saigusa, T., Okada, A., et al. (2020) · Heart and Vessels · doi:10.1007/s00380-020-01659-0 · Cited by 31 · see citing works
Shitara, S., Fujiyoshi, A., Hisamatsu, T., Torii, S., Suzuki, S., Ito, T., Arima, H., Shiino, A., Nozaki, K., Miura, K., et al. (2019) · Stroke · doi:10.1161/strokeaha.119.025964 · Cited by 29 · see citing works
Self-citationTsukinoki, R., Okamura, T., Watanabe, M., Kokubo, Y., Higashiyama, A., Nishimura, K., Takegami, M., Murakami, Y., Okayama, A., & Miyamoto, Y. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu059 · Cited by 27 · see citing works
Self-citationSeino, S., Kitamura, A., Abe, T., Taniguchi, Y., Yokoyama, Y., Amano, H., Nishi, M., Nofuji, Y., Narita, M., Ikeuchi, T., et al. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2019.11.018 · Cited by 26 · see citing works
Cui, J., Sun, J., Wang, W., Xin, H., Qiao, Q., Baloch, Z., & Ma, A. (2017) · Oncotarget · doi:10.18632/oncotarget.21969 · Cited by 24 · see citing works
Kwon, D., Yi, J., Ohrr, H., & Yi, S. (2019) · Medicine · doi:10.1097/md.0000000000017013 · Cited by 24 · see citing works
Satoh, M., Ohkubo, T., Asayama, K., Murakami, Y., Sugiyama, D., Waki, T., Tanaka‐Mizuno, S., Yamada, M., Saitoh, S., Sakata, K., et al. (2020) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.52613 · Cited by 24 · see citing works
Self-citationfor the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) Research Group, Hirata, T., Sugiyama, D., Nagasawa, S.-Y., Murakami, Y., Saitoh, S., Okayama, A., Iso, H., Irie, F., Sairenchi, T., et al. (2017) · European Journal of Epidemiology · doi:10.1007/s10654-016-0203-1 · Cited by 23 · see citing works
Self-citationMomayyezi, M., Jambarsang, S., Fallahzadeh, H., & Sefidkar, R. (2024) · BMC Public Health · doi:10.1186/s12889-024-18734-0 · Cited by 23 · see citing works
Ghasemzadeh, Z., Abdi, H., Asgari, S., Tohidi, M., Khalili, D., Valizadeh, M., Moeini, S., Eidkhani, V., Azizi, F., & Hadaegh, F. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0102-1 · Cited by 23 · see citing works
Endurance training enhances LXRα gene expression in Wistar male rats
Kazeminasab, F., Marandi, M., Ghaedi, K., Esfarjani, F., & Moshtaghian, J. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-013-2658-z · Cited by 22 · see citing works
Okamura, T., Sekikawa, A. M., Sawamura, T., Kadowaki, T., Barinas‐Mitchell, E., Mackey, R. H., Kadota, A., Evans, R. G., Edmundowicz, D., Higashiyama, A., et al. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.04.023 · Cited by 21 · see citing works
Self-citationSerum Uric Acid and Mortality Form Cardiovascular Disease: EPOCH-JAPAN Study
Zhang, W., Iso, H., Murakami, Y., Miura, K., Nagai, M., Sugiyama, D., Ueshima, H., Okamura, T., & EPOCH-JAPAN GROUP (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.er31591 · Cited by 20 · see citing works
Self-citationHirata, A., Kakino, A., Okamura, T., Usami, Y., Fujita, Y., Kadota, A., Fujiyoshi, A., Hisamatsu, T., Kondo, K., Segawa, H., et al. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.09.013 · Cited by 19 · see citing works
Self-citationChen, C., Wang, D., Xia, H., Wang, F., Yang, X., Pan, D., Wang, S., Yang, L., Lu, H., Shu, G., et al. (2018) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2018.1504009 · Cited by 20 · see citing works
Liu, J., Dan, W., Liu, X., Zhong, X., Chen, C., He, Q., & Wang, J. (2023) · Health Information Science and Systems · doi:10.1007/s13755-023-00215-0 · Cited by 18 · see citing works
Mitra, M., Shah, N., Faridi, M., Ghosh, A. K., Sankaranarayanan, V. S., Aggarwal, A., Chatterjee, S., Bhattacharya, N., Kadhe, G., Vishnoi, G., et al. (2015) · Human Vaccines & Immunotherapeutics · doi:10.4161/21645515.2014.979646 · Cited by 18 · see citing works
Lin, L., Kiryakos, J., Ammous, F., Ratliff, S., Ware, E., Faul, J., Kardia, S., Zhao, W., Birditt, K. S., & Smith, J. A. (2024) · BMC Medical Genomics · doi:10.1186/s12920-024-01914-7 · Cited by 14 · see citing works
Sugiyama, D., Turin, T. C., Yeasmin, F., Rumana, N., Watanabe, M., Higashiyama, A., Takegami, M., Kokubo, Y., Okamura, T., & Miyamoto, Y. (2019) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.49098 · Cited by 17 · see citing works
Self-citationZawieja, E. E., Zawieja, B. E., & Chmurzyńska, A. (2019) · Journal of Dietary Supplements · doi:10.1080/19390211.2019.1699223 · Cited by 17 · see citing works
Chiu, Y.-W., Wu, C., Chen, P., Wei, Y., Hsu, L., & Wang, S. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.01.016 · Cited by 17 · see citing works
Dietary tofu intake and long-term risk of death from stroke in a general population
Nguyen, H. N., Miyagawa, N., Miura, K., Okuda, N., Yoshita, K., Arai, Y., Nakagawa, H., Sakata, K., Ojima, T., Kadota, A., et al. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.11.021 · Cited by 16 · see citing works
Self-citationCui, J., Sun, J., Wang, W., Yasmeen, N., Ma, K., Xin, H., Qiao, Q., Ma, A., & Baloch, Z. (2018) · BMC Public Health · doi:10.1186/s12889-018-5286-z · Cited by 15 · see citing works
Murakami, Y. (2014) · Journal of Epidemiology · doi:10.2188/jea.je20130177 · Cited by 14 · see citing works
Self-citationSerum γ-glutamyltransferase and Mortality due to Cardiovascular Disease in Japanese Men and Women
Li, Y., Iso, H., Cui, R., Murakami, Y., Yatsuya, H., Miura, K., Nagasawa, S., Ueshima, H., & Okamura, T. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.32698 · Cited by 13 · see citing works
Self-citationImpact of enzyme-inducing anti-epilepsy drugs on lipid levels in elderly patients with epilepsy
Okada, S., Nishina, M., Koizumi, K., Katayama, M., Inoue, S., & Suga, S. (2020) · Epilepsy Research · doi:10.1016/j.eplepsyres.2020.106428 · Cited by 12 · see citing works
Turusheva, A. V., Vaes, B., Degryse, J., & Frolova, E. V. (2020) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2020.104180 · Cited by 12 · see citing works
Shibata, Y., Ojima, T., Nakamura, M., Kuwabara, K., Miyagawa, N., Saito, Y., Nakamura, Y., Kiyohara, Y., Nakagawa, H., Fujiyoshi, A., et al. (2018) · Journal of Epidemiology · doi:10.2188/jea.je20170229 · Cited by 11 · see citing works
Self-citationShih, Y.-L., Shih, C.-C., & Chen, J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235277 · Cited by 11 · see citing works
Song, X., Wang, H., Su, C., Wang, Z., Du, W., Huang, F., Zhang, J., Jia, X., Jiang, H., Ouyang, Y., et al. (2021) · Nutrients · doi:10.3390/nu13103488 · Cited by 11 · see citing works
Nakai, M., Miyamoto, Y., Higashiyama, A., Murakami, Y., Nishimura, K., Yatsuya, H., Saitoh, S., Sakata, K., Iso, H., Miura, K., et al. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.31286 · Cited by 10 · see citing works
Self-citationThe effect of long-term valproic acid treatment in the level of total cholesterol among adult
Jaeri, S., & Kusumastuti, K. (2020) · Indian Journal of Pharmacology · doi:10.4103/ijp.ijp_655_18 · Cited by 10 · see citing works
Jarauta, E., Bea, A. M., Marco-Benedí, V., & Lamíquiz-Moneo, I. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.554931 · Cited by 9 · see citing works
Initial serum cholesterol level as a potential marker for post cardiac arrest patient outcomes
Chae, M. K., Lee, S. E., Min, Y. G., & Park, E.-J. (2019) · Resuscitation · doi:10.1016/j.resuscitation.2019.11.003 · Cited by 9 · see citing works
Shi, J., Li, R., Liu, Y., Lu, H., Yu, L., & Zhang, F. (2019) · BioMed Research International · doi:10.1155/2019/4805926 · Cited by 8 · see citing works
Imai, Y., Tanaka, S., Satoh, M., Hirata, T., Murakami, Y., Miura, K., Waki, T., Hirata, A., Sairenchi, T., Irie, F., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.021753 · Cited by 8 · see citing works
Self-citationKo, M. J., Kim, Y. J., Park, C. M., Lee, S., Lee, W. J., Pencina, M. J., Navar‐Boggan, A. M., & Park, D. (2015) · American Heart Journal · doi:10.1016/j.ahj.2015.06.012 · Cited by 8 · see citing works
Psychological Risk Factors for the Development of Stroke in the Elderly
Ito, H. (2013) · Journal of Neurology & Neurophysiology · doi:10.4172/2155-9562.1000147 · Cited by 8 · see citing works
The Potential Mechanisms of Effect of Valproic Acid on Lipid Profiles: An Updated Review
Jaeri, S., & Islamiyah, W. R. (2018) · Journal of Epileptology · doi:10.21307/jepil-2018-005 · Cited by 7 · see citing works
Cardiovascular risk and blood pressure lowering treatment among elderly individuals
Asayama, K., Ohkubo, T., Satoh, A., Tanaka, S., Higashiyama, A., Murakami, Y., Yamada, M., Saitoh, S., Okayama, A., Miura, K., et al. (2017) · Journal of Hypertension · doi:10.1097/hjh.0000000000001555 · Cited by 7 · see citing works
Self-citationYamashita, S., Fujita, H., Yokota, D., Isogai, Y., & Kitamoto, R. (2025) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.65336 · Cited by 6 · see citing works
Campisi, M., Cannella, L., Bordin, A., Moretto, A., Scapellato, M. L., Mason, P., Liviero, F., Pavanello, S., & on behalf of Occupational Medicine Working Group (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158056 · Cited by 5 · see citing works
Myung, H. J., Jeong, H. S., Hwang, T. Y., Go, K. H., Kim, J., Cho, W., Choi, Y. K., Park, J., & Hong, S. J. (2016) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2016.5.1.49 · Cited by 5 · see citing works
Zheng, W., Zhang, J., Huang, Y., Wang, S., Gao, X., Yang, Z., Zong, Y., & Yang, Z. (2024) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-024-00694-6 · Cited by 4 · see citing works
Ukawa, S., Tamakoshi, A., Murakami, Y., Kiyohara, Y., Yamada, M., Nagai, M., Satoh, A., Miura, K., Ueshima, H., Okamura, T., et al. (2018) · Europe PMC (PubMed Central) · doi:10.22034/apjcp.2018.19.8.2089 · Cited by 4 · see citing works
Self-citationRisk factors for ischemic heart disease in males in the prime of life: An eight-year follow-up study
Hatanaka, Y., Tamakoshi, A., & Tsushita, K. (2015) · SANGYO EISEIGAKU ZASSHI · doi:10.1539/sangyoeisei.b14008 · Cited by 4 · see citing works
Self-citationCui, M., Chiang, C., Cui, R., Honjo, K., Yatsuya, H., Watson, B. M., Ikerdeu, E., Mita, T., Madraisau, S., Aoyama, A., et al. (2018) · Journal of Epidemiology · doi:10.2188/jea.je20170127 · Cited by 4 · see citing works
Self-citationDyslipidemia paradox: Analysis from the veterans exercise testing study
Vainshelboim, B., & MYERS, J. N. (2023) · PLoS ONE · doi:10.1371/journal.pone.0287923 · Cited by 3 · see citing works
A Multicenter Prospective Hospital-based Cohort Study on the Efficacy and Safety of Pitavastatin
Shehab, A. M., Elnour, A. A., Bhagavathula, A. S., Kurian, J. P., Hassan, G., AlZaabi, S., Gilbert, H., & Al‐Rasadi, K. (2020) · Current Diabetes Reviews · doi:10.2174/1573399817666201228164243 · Cited by 3 · see citing works
The association between rapid growth and lipid profile: a systematic review and meta-analysis
Chen, B., Chen, Y., Wang, Y., Xin, Q., & Ma, D. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1353334 · Cited by 3 · see citing works
Towards Optimal Cardiovascular Health: A Comprehensive Review of Preventive Strategies
Branigan, P., Duong, Y. V., Abdulfattah, A., Sabu, J., Mallappallil, M. C., & John, S. (2024) · Cureus · doi:10.7759/cureus.60877 · Cited by 4 · see citing works
Zhuo, S., & Yuan, C. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.10.007 · Cited by 3 · see citing works
Kunimura, A., Miura, K., Segawa, H., Torii, S., Kondo, K., Hisamatsu, T., Kadota, A., Fujiyoshi, A., Yano, Y., Nakagawa, Y., et al. (2022) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.63549 · Cited by 3 · see citing works
Self-citationSong, X., Wang, H., Zhang, M., Meng, J., Su, C., Zou, Q., & Zhang, B. (2023) · Chronobiology International · doi:10.1080/07420528.2023.2195492 · Cited by 2 · see citing works
Effect on lipid profile due to prolong Valproic acid intake
Aziz, R. S., Saeed, U., Ali, L., Arshad, M., Abbas, R., Mushtaq, S., Shahzad, A., & Shaukat, A. (2021) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs211571497 · Cited by 2 · see citing works
Castilla, E., Morillas, P., Gómez, M., Ahumada, M., Monteagudo, M., Fácila, L., & Pallarés‐Carratalá, V. (2016) · Medicina Clínica · doi:10.1016/j.medcli.2016.03.015 · Cited by 2 · see citing works
Bouhika, E. J., Boussana, A., Kounga, P. R. M., Nsompi, F., Moussouami, S. I., Calvin, M. B., Lolo, D. S., Pambou, R. A. C. B., Okouango, Y. S. I., Elenga, M., et al. (2022) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2022.109024 · Cited by 2 · see citing works
Lin, L., Kiryakos, J., Ammous, F., Ratliff, S. M., Ware, E. B., Faul, J. D., Kardia, S. L. R., Zhao, W., Birditt, K. S., & Smith, J. A. (2024) · Research Square · doi:10.21203/rs.3.rs-3934965/v1 · Cited by 2 · see citing works
Effects of Fuji Apple Juice on Total Cholesterol Levels in Hypercholesterolemic Elderly People
Harsono, R. D. A., Dewi, Y. L. R., & Lestari, A. (2022) · Nutrition and Food Sciences Research · doi:10.52547/nfsr.9.1.15 · Cited by 1 · see citing works
Yao, X., Lai, H., Ma, K., Zhao, B., He, A., Sun, W., Wang, Y., & Song, H. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02698-0 · Cited by 1 · see citing works
Castilla, E., Morillas, P., Gómez, M., Ahumada, M., Monteagudo, M., Fácila, L., & Pallarés‐Carratalá, V. (2016) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2016.07.002 · Cited by 1 · see citing works
Miura, K., & Ueshima, H. (2013) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.102.282 · Cited by 1 · see citing works
Self-citationBahr, N., Abdelkader, A., Demellawy, M. E., Salah-Eldin, A.-E., & Ghareeb, D. A. (2022) · Aswan University Journal of Environmental Studies · doi:10.21608/aujes.2022.128494.1061 · Cited by 1 · see citing works
Colesterol total en dislipidemias
Calvo-Betancourt, L. S., Ardila, D. J. A., García-Peña, Á. A., Múñoz, Ó., & Ruiz, Á. (2019) · Acta Médica Colombiana · doi:10.36104/amc.2019.1320 · Cited by 1 · see citing works
Shevchenko, A. V., Doronin, B. M., Kuznetsova, V. B., & Amstislavskaya, T. G. (2015) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro201511512243-47
Ragino, Y. V., Stakhneva, E. M., Sadovski, E. V., Щербакова, Л. В., & Malyutina, S. K. (2016) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2016-6-41-44
Shevcehnko, A. V., Doronin, B. M., Kuznetsova, V. B., & Amstislavskaya, T. G. (2016) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro20161168252-56
Lifetime Risk as a Tool to Encourage Young Adults with High Cardiovascular Risk in Asia
Satoh, M. (2019) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.ed117
Prevention of Stroke by Lowering Blood Cholesterol Concentrations
Paciaroni, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781316286234.017
Dyslipidemia management in geriatric patients: new guidelines 2017
俊一郎, 大., 一貴, 小., & 幸太郎, 横. (2019) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.56.417
Adele, B. O., Okonkwo, C. J., Odetola, A. O., Emediong, I. E., Ige, A. O., & Adewoye, E. O. (2022) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2022.1012016
การศกษาเปรยบเทยบอตราการเกดโรคหวใจและหลอดเลอดระหวางพนกงานในสำนกงานและพนกงานทใชแรงงานขององคกรแหงหนง
ศรีเจริญธรรม, ส., ศุภพงษ์, ส., รัตนานุพงศ์, ธ., & เอกพลากร, ว. (2017) · doi:10.58837/chula.the.2017.760
A Study of LDL Status of Stroke Patient Admitted in Tertiary Care Hospital
Sarker, N. R., Nabi, Q. M. R. U., Saha, S. K., Ghosh, L. C., & Khan, M. E. U. (2023) · Sir Salimullah Medical College Journal · doi:10.3329/ssmcj.v31i1.69361
Lin, L., Kiryakos, J., Ammous, F., Ratliff, S. M., Ware, E. B., Faul, J. D., Kardia, S. L. R., Zhao, W., Birditt, K. S., & Smith, J. A. (2024) · Figshare · doi:10.6084/m9.figshare.25910051
Song, Z., Takada, M., Hong, Y.-J., Endale, B. T., Nishio, N., Horikoshi, M., Khine, M. T., MATSUNAGA, M., He, Y., Ota, A., et al. (2025) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-025-02189-w
Fujioka, Y., Tanaka, S.-I., Tsujino, T., Ishida, T., & Hirata, K. (2026) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.66073
宮川, 尚., 齋藤, 祥., 中村, 保., 門田, 文., 上島, 弘., 三浦, 克., Shibata, Y., Ojima, T., Nakamura, M., Kuwabara, K., et al. (2018) · Institutional Repositories DataBase (IRDB)
Self-citation
- Authors
- Nagasawa, S., Okamura, T., Iso, H., Tamakoshi, A., Yamada, M., Watanabe, M., Murakami, Y., Miura, K., Ueshima, H., & for the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH‐JAPAN) Research Group
- Affiliations
- Department of Epidemiology and Public Health, Kanazawa Medical University, Ishikawa, Japan
- Keio University (JP)
- The University of Osaka (JP)
- Aichi Medical University (JP)
- Radiation Effects Research Foundation (JP)
- National Cerebral and Cardiovascular Center (JP)
- Shiga University of Medical Science (JP)
- ORCID
- Venue
- Journal of the American Heart Association
- Published
- 2012-09-26
- Volume
- 1
- Issue
- 5
- Pages
- e001974-e001974
- ISSN
- 2047-9980 (ISSN-L)
- PMC
- PMC3541631
- OpenAlex
- W2101888700
- Cited by
- 101
- References
- 40
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 9 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 13 · 2019: 13 · 2018: 11 · 2017: 6 · 2016: 13 · 2015: 6 · 2014: 5 · 2013: 5
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Journal of the American Heart Association (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- total cholesterol, cardiovascular disease, coronary artery disease, stroke, cerebral infarction, cerebral hemorrhage, sex differences, age differences, older adults, middle-aged adults, Japanese population, pooled analysis of cohort studies
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Cardiovascular Diseases, Cholesterol, Female, Humans, Japan, Male, Middle Aged, Risk Factors, Sex Factors, Cohort Studies, Proportional Hazards Models, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review