CoChat
Sign Up
Cited by 35Asthma and respiratory diseasesVaccine Coverage and HesitancyImmune responses and vaccinations

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Measles-Mumps-Rubella Vaccination and Asthma-like Disease in Early Childhood

Open access
Hviid, A., Melbye, M.·2008·American Journal of Epidemiology
DOI 10.1093/aje/kwn253
Open this paper in CoChat — free account

Abstract

The authors evaluated the association between receipt of measles-mumps-rubella (MMR) vaccine and asthma-like disease in early childhood in a Danish nationwide cohort study (N = 871,234). Two outcomes were included: hospitalizations with asthma diagnoses and use of anti-asthma medications (for a subset of the cohort only). Poisson regression was used to estimate rate ratios according to vaccination status. MMR-vaccinated children were less often hospitalized with an asthma diagnosis (rate ratio (RR) = 0.75, 95% confidence interval (CI): 0.73, 0.78) and used fewer courses of anti-asthma medication (RR = 0.92, 95% CI: 0.91, 0.92) than unvaccinated children. This "protective" effect of MMR vaccine was more pronounced for hospitalizations with severe asthma diagnoses (status asthmaticus: RR = 0.63, 95% CI: 0.49, 0.82) and use of medication that was highly specific for asthma (long-acting beta2-agonist inhalant: RR = 0.68, 95% CI: 0.63, 0.73). MMR vaccine was not negatively associated with anti-asthma medications often used for wheezing illnesses in early childhood (systemic beta2-agonist: RR = 1.02, 95% CI: 1.01, 1.02). These results are compatible not with an increased risk of asthma following MMR vaccination but rather with the hypothesis that MMR vaccination is associated with a reduced risk of asthma-like disease in young children.

Overview

Integrity signals

Registry

Crossref · 10.1093/aje/kwn253

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. Andersen, 1999, Danish medical bulletin, 46, 263
  2. 2001, Chest Meeting Abstracts, 119, 1913

Cited by

Sorted by citations

Related

Metadata

Authors
Hviid, A., & Melbye, M.
Affiliations
Statens Serum Institut (DK)
ORCID
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2008-10-15
Volume
168
Issue
11
Pages
1277-1283
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
DOI
10.1093/aje/kwn253
OpenAlex
W2099997910
Cited by
35
References
26
Citations by year
2023: 1 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 5
FWCI
1.58
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Social Sciences › Health › Vaccine Coverage and Hesitancy
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords
MMR vaccine, asthma, childhood asthma, asthma hospitalization, status asthmaticus, wheezing, vaccine safety, early childhood
MeSH terms
Asthma, Child, Preschool, Denmark, Drug Utilization, Female, Hospitalization, Humans, Infant, Male, Cohort Studies, Confidence Intervals, Poisson Distribution, Odds Ratio, Treatment Outcome, Anti-Asthmatic Agents, Measles-Mumps-Rubella Vaccine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review