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Multiple Imputation With Large Data Sets: A Case Study of the Children's Mental Health Initiative

Open access
Stuart, E. A., Azur, M., Frangakis, C., Leaf, P.·2009·American Journal of Epidemiology

Abstract

Multiple imputation is an effective method for dealing with missing data, and it is becoming increasingly common in many fields. However, the method is still relatively rarely used in epidemiology, perhaps in part because relatively few studies have looked at practical questions about how to implement multiple imputation in large data sets used for diverse purposes. This paper addresses this gap by focusing on the practicalities and diagnostics for multiple imputation in large data sets. It primarily discusses the method of multiple imputation by chained equations, which iterates through the data, imputing one variable at a time conditional on the others. Illustrative data were derived from 9,186 youths participating in the national evaluation of the Community Mental Health Services for Children and Their Families Program, a US federally funded program designed to develop and enhance community-based systems of care to meet the needs of children with serious emotional disturbances and their families. Multiple imputation was used to ensure that data analysis samples reflect the full population of youth participating in this program. This case study provides an illustration to assist researchers in implementing multiple imputation in their own data.

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Metadata

Authors
Stuart, E. A., Azur, M., Frangakis, C., & Leaf, P.
Venue
American Journal of Epidemiology
Published
2009-03-24
Volume
169
Issue
9
Pages
1133-1139
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
OpenAlex
W2168089684
Cited by
268
References
6
FWCI
7.65
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Multiple Imputation With Large Data Sets: A Case Study of the Children's Mental Health Initiative. https://app.cochat.ai/papers/10.1093/aje/kwp026
The paper
Stuart, E. A., Azur, M., Frangakis, C., & Leaf, P. (2009). Multiple Imputation With Large Data Sets: A Case Study of the Children's Mental Health Initiative. American Journal of Epidemiology. https://doi.org/10.1093/aje/kwp026

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.