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Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): Objectives and Design

Open access
Aquino, E. M. L., Barreto, S. M., Bensenor, I. M., Carvalho, M. S., Chor, D., Duncan, B. B., Lotufo, P. A., Mill, J. G., Molina, M. D. C., Mota, E. L. A., Azeredo Passos, V. M., Schmidt, M. I., Szklo, M.·2012·American Journal of Epidemiology

Abstract

Although low- and middle-income countries still bear the burden of major infectious diseases, chronic noncommunicable diseases are becoming increasingly common due to rapid demographic, epidemiologic, and nutritional transitions. However, information is generally scant in these countries regarding chronic disease incidence, social determinants, and risk factors. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute relevant information with respect to the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular diseases and diabetes. In this report, the authors delineate the study's objectives, principal methodological features, and timeline. At baseline, ELSA-Brasil enrolled 15,105 civil servants from 5 universities and 1 research institute. The baseline examination (2008-2010) included detailed interviews, clinical and anthropometric examinations, an oral glucose tolerance test, overnight urine collection, a 12-lead resting electrocardiogram, measurement of carotid intima-media thickness, echocardiography, measurement of pulse wave velocity, hepatic ultrasonography, retinal fundus photography, and an analysis of heart rate variability. Long-term biologic sample storage will allow investigation of biomarkers that may predict cardiovascular diseases and diabetes. Annual telephone surveillance, initiated in 2009, will continue for the duration of the study. A follow-up examination is scheduled for 2012-2013.

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Metadata

Authors
Aquino, E. M. L., Barreto, S. M., Bensenor, I. M., Carvalho, M. S., Chor, D., Duncan, B. B., Lotufo, P. A., Mill, J. G., Molina, M. D. C., Mota, E. L. A., Azeredo Passos, V. M., Schmidt, M. I., & Szklo, M.
Venue
American Journal of Epidemiology
Published
2012-01-10
Volume
175
Issue
4
Pages
315-324
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
OpenAlex
W2145427343
Cited by
825
References
6
FWCI
22.64
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): Objectives and Design. https://app.cochat.ai/papers/10.1093/aje/kwr294
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Aquino, E. M. L., Barreto, S. M., Bensenor, I. M., Carvalho, M. S., Chor, D., Duncan, B. B., Lotufo, P. A., Mill, J. G., Molina, M. D. C., Mota, E. L. A., Azeredo Passos, V. M., Schmidt, M. I., & Szklo, M. (2012). Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): Objectives and Design. American Journal of Epidemiology. https://doi.org/10.1093/aje/kwr294

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.