Pregnancy-Induced Hypertension and Diabetes and the Risk of Cardiovascular Disease, Stroke, and Diabetes Hospitalization in the Year Following Delivery
Open accessAbstract
Although pregnancy events predict the long-term risk of chronic disease, little is known about their short-term impact because of the rarity of clinical events. We examined hospital discharge diagnoses linked to birth certificate data in the year following delivery for 849,639 births during 1995-2004 in New York City, New York. Adjusted odds ratios characterized the relationship between pregnancy complications and subsequent hospitalization for cardiovascular disease, stroke, and diabetes. Gestational hypertension was related to heart failure (adjusted odds ratio = 2.6, 95% confidence interval: 1.5, 4.5). Preeclampsia was related to all of the outcomes considered except type 1 diabetes, with adjusted odds ratios ranging from 2.0 to 4.1. Gestational diabetes was strongly related to the risk of subsequent diabetes (for type 1 diabetes, adjusted odds ratio = 40.4, 95% confidence interval: 23.8, 68.5; for type 2 diabetes, adjusted odds ratio = 22.6, 95% confidence interval: 16.9, 30.4) but to no other outcomes. The relationship of pregnancy complications to future chronic disease is apparent as early as the year following delivery. Moreover, elucidating short-term clinical outcomes offers the potential for etiological insights into the relationship between pregnancy events and chronic disease over the life course.
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Evidence of an association between gestational diabetes and heart failure is inconclusive.
“Evidence of an association between gestational diabetes and heart failure87 was inconclusive however (supplementary table 4).100 101”
From Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review (2020) · cites this paper as [101]
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- Authors
- Savitz, D. A., Danilack, V. A., Elston, B., & Lipkind, H. S.
- Affiliations
- Brown University (US)
- Corresponding author
- Savitz, D. A.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-05-30
- Volume
- 180
- Issue
- 1
- Pages
- 41-44
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- PMC
- PMC4070939
- OpenAlex
- W2124916306
- Cited by
- 120
- References
- 16
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 9 · 2023: 15 · 2022: 17 · 2021: 13 · 2020: 8 · 2019: 13 · 2018: 6 · 2017: 14 · 2016: 9 · 2015: 4 · 2014: 2
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Yale University
- Brown University
- U.S. Public Health Service (R21 58111)
- National Institute of Child Health and Human Development
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- gestational hypertension, preeclampsia, gestational diabetes mellitus, type 1 diabetes, type 2 diabetes, heart failure, stroke, cardiovascular disease, diabetes-related hospitalization, postpartum period, pregnancy complications, chronic disease risk, birth certificate data
- MeSH terms
- Cardiovascular Diseases, Coronary Disease, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Heart Failure, Hospitalization, Humans, Hypertension, New York City, Pregnancy, Pregnancy Complications, Cardiovascular, Pregnancy in Diabetics, Risk Factors, Venous Thrombosis, Intracranial Hemorrhages, Stroke
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