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Reduced Risk of Lung Cancer With Metformin Therapy in Diabetic Patients: A Systematic Review and Meta-Analysis
Abstract
Emerging evidence from epidemiologic studies and basic science suggests an inverse association between metformin use and cancer risk in diabetic patients. However, the association with lung cancer is not consistent. We summarized the evidence currently available (2009-2013) and explored sources of heterogeneity. Metformin therapy was associated with significantly lower risks of cancers of the lung (4 studies; pooled relative risk = 0.71, 95% confidence interval (CI): 0.55, 0.95; P = 0.02) and respiratory system (6 studies; pooled relative risk = 0.85, 95% CI: 0.75, 0.96; P = 0.01). There was evidence of moderate heterogeneity (I(2) > 50%). The major sources of heterogeneity were smoking adjustment status and cancer site. The relative risk from studies that adjusted for smoking was 1.16-fold (95% CI: 1.00, 1.35) closer to the null than that from studies not adjusting for smoking. The relative risk of respiratory cancer was 1.23-fold (95% CI: 1.02, 1.49) closer to the null than that for lung cancer. In conclusion, metformin use appears to be associated with lower risks of lung and respiratory cancer in diabetic patients. However, caution regarding overestimation is needed, since adjustment for smoking attenuates the association.
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“Originally introduced for the treatment of diabetes, metformin is now gaining attention as a potential anti-cancer agent (7–10) (Figure 1).”
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“this finding has subsequently been confirmed in several other studies(7–10).”
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Cites
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 55,077
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763
von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., Vandenbroucke, J. P., & Initiative, F. T. S. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-8-200710160-00010 · Cited by 17,796
Quantitative Synthesis in Systematic Reviews
Lau, J., Ioannidis, J. P. A., & Schmid, C. H. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-127-9-199711010-00008 · Cited by 2,517
Chen, Y., Ebenstein, A. Y., Greenstone, M., & Li, H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300018110 · Cited by 1,819
Raaschou‐Nielsen, O., Andersen, Z. J., Beelen, R. M. J., Samoli, E., Stafoggia, M., Weinmayr, G., Hoffmann, B. H., Fischer, P. H., Nieuwenhuijsen, M. J., Brunekreef, B., et al. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70279-1 · Cited by 1,667
Lee, I.-M., Cook, N. R., Gaziano, J. M., Gordon, D., Ridker, P. M., Manson, J. E., Hennekens, C. H., & Buring, J. E. (2005) · JAMA · doi:10.1001/jama.294.1.56 · Cited by 1,137
New Users of Metformin Are at Low Risk of Incident Cancer
Libby, G., Donnelly, L. A., Donnan, P. T., Alessi, D. R., Morris, A. D., & Evans, J. M. M. (2009) · Diabetes Care · doi:10.2337/dc08-2175 · Cited by 996
Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis
DeCensi, A., Puntoni, M., Goodwin, P., Cazzaniga, M., Gennari, A., Bonanni, B., & Gandini, S. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0157 · Cited by 918
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Romero, R., Erez, O., Hüttemann, M., Maymon, E., Panaitescu, B., Conde-Agudelo, A., Pacora, P., Yoon, B. H., & Grossman, L. I. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.06.003 · Cited by 253
Metformin attenuates lung fibrosis development via NOX4 suppression
Sato, N., Takasaka, N., Yoshida, M., Tsubouchi, K., Minagawa, S., Araya, J., Saito, N., Fujita, Y., Kurita, Y., Kobayashi, K., et al. (2016) · Respiratory Research · doi:10.1186/s12931-016-0420-x · Cited by 233
Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions
Vernieri, C., Casola, S., Foiani, M., Pietrantonio, F., de Braud, F., & Longo, V. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0615 · Cited by 202
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Chiang, C., Chao, T., Su, Y., Hsu, C., Chien, C., Chiu, K., Shiah, S., Lee, C.-H., Liu, S.-Y., & Shieh, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.14982 · Cited by 188
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Zhao, Y. D., Wang, W., Guo, S., Wang, Y., Miao, L., Xiong, Y., & Huang, L. (2016) · Nature Communications · doi:10.1038/ncomms11822 · Cited by 173
Ding, L., Liang, G., Yao, Z., Zhang, J., Liu, R., Chen, H., Zhou, Y., Wu, H., Yang, B., & He, Q. (2015) · Oncotarget · doi:10.18632/oncotarget.5541 · Cited by 170
Diabetes and cancer: Pathophysiological fundamentals of a ‘dangerous affair’
Cignarelli, A., Genchi, V. A., Caruso, I., Natalicchio, A., Perrini, S., Laviola, L., & Giorgino, F. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.04.002 · Cited by 156
Kowall, B., Stang, A., Rathmann, W., & Kostev, K. (2015) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3823 · Cited by 100
Skinner, H. D., Hu, C., Tsakiridis, T. K., Santana-Dávila, R., Lü, B., Erasmus, J. J., Doemer, A., Videtic, G. M. M., Coster, J. R., Yang, A. X., et al. (2021) · JAMA Oncology · doi:10.1001/jamaoncol.2021.2318 · Cited by 99
Chemotherapy targeting cancer stem cells.
Liu, H., Lv, L. L., & Yang, K. (2015) · PubMed Central · Cited by 94
O’Brien, A. J., Villani, L. A., Broadfield, L. A., Houde, V. P., Galić, S., Blandino, G., Kemp, B. E., Tsakiridis, T. K., Muti, P. C., & Steinberg, G. R. (2015) · Biochemical Journal · doi:10.1042/bj20150122 · Cited by 90
Is metformin poised for a second career as an antimicrobial?
Malik, F. R., Mehdi, S. F., Ali, H., Patel, P., Basharat, A., Kumar, A., Ashok, F., Stein, J., Brima, W., Malhotra, P., et al. (2017) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2975 · Cited by 89
Liu, X., Jiang, J., Yu, C., Wang, Y., Sun, Y., Tang, J., Chen, T., Bi, Y., Liu, Y., & Zhang, Z. (2019) · Cancer Epidemiology · doi:10.1016/j.canep.2019.05.011 · Cited by 87
Self-citationDiabetes induces fibrotic changes in the lung through the activation of TGF-β signaling pathways
Talakatta, G., Sarikhani, M., Muhamed, J., Dhanya, K., Somashekar, B. S., Mahesh, P. A., Sundaresan, N. R., & Veeranna, R. P. (2018) · Scientific Reports · doi:10.1038/s41598-018-30449-y · Cited by 83
Role of Metformin on Osteoblast Differentiation in Type 2 Diabetes
Jiating, L., Buyun, J., & Zhang, Y. (2019) · BioMed Research International · doi:10.1155/2019/9203934 · Cited by 80
Zhou, X., Xue, W., Ding, X., Li, L., Dou, M., Zhang, W., Lv, Z., Fan, Z., Zhao, J., & Wang, L. (2017) · Oncotarget · doi:10.18632/oncotarget.16973 · Cited by 74
Metformin in Lung Cancer: Review of in Vitro and in Vivo Animal Studies
Yousef, M., & Tsiani, E. (2017) · Cancers · doi:10.3390/cancers9050045 · Cited by 75
Rising Mortality Rate of Cervical Cancer in Younger Women in Urban China
Wei, M., Zhou, W., Bi, Y., Wang, H., Liu, Y., & Zhang, Z.-J. (2018) · Journal of General Internal Medicine · doi:10.1007/s11606-018-4732-z · Cited by 68
Self-citationGuo, L., Cui, J., Wang, H., Medina, R., Zhang, S., Zhang, X., Zhuang, Z., & Lin, Y. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2020.11.004 · Cited by 64
Murff, H. J., Roumie, C. L., Greevy, R. A., Hackstadt, A. J., McGowan, L. D., Hung, A. M., Grijalva, C. G., & Griffin, M. R. (2018) · Cancer Causes & Control · doi:10.1007/s10552-018-1058-4 · Cited by 65
Metformin: A Dual-Role Player in Cancer Treatment and Prevention
Galal, M. A., Al-Rimawi, M., Hajeer, A., Dahman, H., Alouch, S. S., & Aljada, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074083 · Cited by 73
Metformin Use and Lung Cancer Risk in Diabetic Patients: A Systematic Review and Meta-Analysis
Long, Y., Liu, M., Huang, Y., Wu, K., Huang, X., Zhao, Y., He, W., & Zhang, R. (2019) · Disease Markers · doi:10.1155/2019/6230162 · Cited by 55
Metformin and lung cancer risk in patients with type 2 diabetes mellitus
Tseng, C. (2017) · Oncotarget · doi:10.18632/oncotarget.17066 · Cited by 53
Zhang, J., Zhang, Q., Li, Z.-Q., Zhou, J., & Du, J. (2019) · PubMed Central · Cited by 52
Self-citationArrieta, O. G., Varela‐Santoyo, E., Soto‐Pérez‐de‐Celis, E., Sánchez-Reyes, R., la Torre-Vallejo, M. D., Muñiz‐Hernández, S., & Cardona, A. F. (2016) · BMC Cancer · doi:10.1186/s12885-016-2658-6 · Cited by 51
Zhang, Z.-J., Yuan, J., Bi, Y., Wang, C., & Liu, Y. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.01.036 · Cited by 48
Self-citationCui, H., Wang, Y., Yang, S., He, G., Jiang, Z., Gang, X., & Wang, G. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106094 · Cited by 48
Role of p53 Family Proteins in Metformin Anti-Cancer Activities
Yi, Y., Zhang, W., Yi, J., & Xiao, Z. J. (2019) · Journal of Cancer · doi:10.7150/jca.30659 · Cited by 47
Wang, L., Yu, C., Liu, Y., Wang, J., Li, C., Wang, Q., Wang, P., Wu, S., & Zhang, Z. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13111052 · Cited by 45
Self-citationMetformin for non-small cell lung cancer patients: Opportunities and pitfalls
Lévy, A., & Doyen, J. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2018.03.001 · Cited by 46
European Code against Cancer 4th Edition: Medical exposures, including hormone therapy, and cancer
Friis, S., Kesminiene, A., Espina, C., Auvinen, A. P., Straíf, K., & Schüz, J. (2015) · Cancer Epidemiology · doi:10.1016/j.canep.2015.08.003 · Cited by 45
Subbiah, V., Coleman, N., Piha-Paul, S. A., Tsimberidou, A. M., Jankú, F., Rodon, J. A., Pant, S., Dumbrava, E. E. I., Fu, S., Hong, D. S., et al. (2023) · Cancer Research Communications · doi:10.1158/2767-9764.crc-22-0260 · Cited by 42
Liu, X., Yu, C., Wang, Y., Bi, Y., Liu, Y., & Zhang, Z. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16010158 · Cited by 41
Self-citationMetformin with Everolimus and Octreotide in Pancreatic Neuroendocrine Tumor Patients with Diabetes
Pusceddu, S., Buzzoni, R., Vernieri, C., Concas, L., Marceglia, S. R. F., Giacomelli, L., Milione, M., Leuzzi, L., Femia, D., Formisano, B., et al. (2016) · Future Oncology · doi:10.2217/fon-2015-0077 · Cited by 38
Dickerman, B. A., García‐Albéniz, X., Logan, R. W., Denaxas, S., & Hernán, M. Á. (2023) · Epidemiology · doi:10.1097/ede.0000000000001626 · Cited by 36
The association between human papillomavirus infection and female lung cancer
Lin, F. C., Huang, J., Tsai, S. C., Nfor, O. N., Chou, M., Wu, M., Lee, C., Jan, C., & Liaw, Y. (2016) · Medicine · doi:10.1097/md.0000000000003856 · Cited by 33
He, Y., Tai, S., Deng, M., Fan, Z., Ping, F., He, L., Zhang, C., Huang, Y., Cheng, B., & Xia, J. (2019) · Cancer Medicine · doi:10.1002/cam4.2206 · Cited by 32
Wang, Y., Liu, X., Yan, P., Bi, Y., Liu, Y., & Zhang, Z.-J. (2019) · Diabetes & Metabolism · doi:10.1016/j.diabet.2019.04.006 · Cited by 33
Self-citationPharmacological Modulation of Lung Carcinogenesis in Smokers: Preclinical and Clinical Evidence
Flora, S. D., Ganchev, G., Iltcheva, M., Maestra, S. L., Micale, R. T., Steele, V. E., & Balansky, R. M. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.11.003 · Cited by 33
Metformin and pancreatic cancer survival: Real effect or immortal time bias?
Wei, M., Liu, Y., Bi, Y., & Zhang, Z. (2019) · International Journal of Cancer · doi:10.1002/ijc.32254 · Cited by 33
Self-citationDu, L., Wang, M., Kang, Y., Li, B., Guo, M., Cheng, Z., & Bi, C. (2017) · Oncotarget · doi:10.18632/oncotarget.14688 · Cited by 32
Kok, V. C., Chen, Y., Chien, C.-H., Horng, J., & Tsai, J. (2015) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s91513 · Cited by 32
Fixed-Dose Combinations of Pioglitazone and Metformin for Lung Cancer Prevention
Seabloom, D. E., Galbraith, A. R., Haynes, A. M., Antonides, J. D., Wuertz, B. R. K., Miller, W. A., Miller, K. A., Steele, V. E., Miller, M. S., Clapper, M. L., et al. (2017) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-16-0232 · Cited by 30
A Phase Ib Clinical Trial of Metformin and Chloroquine in Patients with IDH1-Mutated Solid Tumors
Khurshed, M., Molenaar, R. J., Linde, M. E. V., Mathôt, R. A. A., Struys, E. A., van Wezel, T., Noorden, C. J. F. V., Klümpen, H., Bovée, J. V. M. G., & Wilmink, J. W. (2021) · Cancers · doi:10.3390/cancers13102474 · Cited by 32
Metformin enhances radiation response of ECa109 cells through activation of ATM and AMPK
Feng, T., Li, L., Ling, S., Fan, N., Fang, M., Zhang, H., Fang, X. H., Lan, W., Hou, Z., Meng, Q.-C., et al. (2014) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2014.11.021 · Cited by 31
Advances in metformin‑based metabolic therapy for non‑small cell lung cancer (Review)
Chen, N., Zhou, Y.-S., Wang, L.-C., & Huang, J. (2022) · Oncology Reports · doi:10.3892/or.2022.8266 · Cited by 29
Translational geroscience: From invertebrate models to companion animal and human interventions
Lee, M. B., & Kaeberlein, M. R. (2018) · Translational Medicine of Aging · doi:10.1016/j.tma.2018.08.002 · Cited by 28
Assessing the Current State of Lung Cancer Chemoprevention: A Comprehensive Overview
Ashraf-Uz-Zaman, M., Bhalerao, A., Mikelis, C. M., Cucullo, L., & German, N. (2020) · Cancers · doi:10.3390/cancers12051265 · Cited by 28
Rising Mortality Rate of Cervical Cancer in Younger Women in Urban China
Chen, T., Wei, M., Liu, Y., Wang, H., Zhou, W., Bi, Y., & Zhang, Z. (2019) · Journal of General Internal Medicine · doi:10.1007/s11606-019-05174-5 · Cited by 25
Self-citationMetformin use and lung cancer survival: a population-based study in Norway
Brandão, S. L. B., Støer, N. C., Weiderpass, E., Damhuis, R. A. M., Johannesen, T. B., Botteri, E., & Strand, T. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01186-9 · Cited by 24
Luo, X., Chen, X., Wang, L., Yang, B., & Cai, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.639016 · Cited by 24
Zhang, Q., Kong, J., Dong, S., Xu, W., & Sun, W. (2017) · Cancer Cell International · doi:10.1186/s12935-017-0418-6 · Cited by 23
Self-citationMoradinazar, M., Najafi, F., Rajati, F., Sarokhani, D., & Bavandpour, M. (2023) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_62_21 · Cited by 23
Zaccardi, F., Davies, M. J., & Khunti, K. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13929 · Cited by 22
Sugiyama, Y., Shudo, T., Hosokawa, S., Watanabe, A., Nakano, M., & Kakizuka, A. (2019) · Genes to Cells · doi:10.1111/gtc.12712 · Cited by 21
Shi, R., Mei, Z., Zhang, Z., & Zhu, Z. (2019) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2019.06.027 · Cited by 21
Self-citationThe Diverse Roles of Adiponectin in Non-Small-Cell Lung Cancer: Current Data and Future Perspectives
Boura, P., Loukides, S., Grapsa, D., Achimastos, A. D., & Syrigos, K. (2015) · Future Oncology · doi:10.2217/fon.15.96 · Cited by 20
Zhang, J., Wu, J., He, Q., Liang, W., & He, J. (2018) · Translational Lung Cancer Research · doi:10.21037/tlcr.2018.03.14 · Cited by 20
Liu, X., Bi, Y., Wang, H., Meng, R., Zhou, W., Zhang, G., Yu, C., & Zhang, Z.-J. (2018) · Public Health · doi:10.1016/j.puhe.2018.08.007 · Cited by 18
Self-citationEvaluation of the pharmacokinetics of metformin and acarbose in the common marmoset
Fernández, E., Ross, C. N., Liang, H., Javors, M. A., Tardif, S. D., & Salmon, A. B. (2019) · Pathobiology of Aging & Age-related Diseases · doi:10.1080/20010001.2019.1657756 · Cited by 18
A phase Ib study of everolimus combined with metformin for patients with advanced cancer
Molenaar, R. J., van de Venne, T., Weterman, M. J., Mathôt, R. A. A., Klümpen, H., Richel, D. J., & Wilmink, J. W. (2017) · Investigational New Drugs · doi:10.1007/s10637-017-0478-4 · Cited by 16
Yang, H., Peng, Y., Ni, H., Li, Y., Shi, Y., Ding, W., & Fan, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130953 · Cited by 16
Zhang, J., Hang, C., Jiang, T., Yi, S., Shao, W., Li, W., & Lin, D. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.570516 · Cited by 18
Obesity-specific improvement of lung cancer outcomes and immunotherapy efficacy with metformin
Smith, R. J., Zollo, R. A., Kalvapudi, S., Vedire, Y., Pachimatla, A. G., Petrucci, C. M., Shaller, G., Washington, D., Vethanayagam, R. R., Sass, S. N., et al. (2024) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djae295 · Cited by 15
Synergistic effect of metformin and EGFR-TKI in the treatment of non-small cell lung cancer
Wang, H., Yang, X. L., Sun, Y., Li, Y., Dong, Y., Shan, D., & Yu, Z. (2020) · Translational Cancer Research · doi:10.21037/tcr.2019.11.09 · Cited by 12
Yang, T., Wang, H., Zhou, Q., Huang, W., Zhang, J., Yu, Y., & Sun, T. (2023) · ACS Applied Nano Materials · doi:10.1021/acsanm.3c00140 · Cited by 12
Metformin and thyroid carcinoma incidence and prognosis: A systematic review and meta-analysis
Wang, Z., Luo, J., Zhang, Y., Xun, P., & Chen, Z. (2022) · PLoS ONE · doi:10.1371/journal.pone.0271038 · Cited by 12
Singh, S. V., Carlo, F. D., Ibrahim, M. A., Penfornis, P., Mouton, A. J., Tripathi, S., Agarwal, A. K., Eastham, L. L., Pasco, D. S., Balachandran, P., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097741 · Cited by 11
Zhang, H., Yang, Y. S., Lee, S., Park, S., Nam, C. M., & Jee, S. H. (2022) · International Journal of Colorectal Disease · doi:10.1007/s00384-022-04212-9 · Cited by 10
Will metformin use lead to a decreased risk of thyroid cancer? A systematic review and meta-analyses
Li, H., Chen, Y., Hu, L., Yang, W., Gao, Z., Liu, M., Tao, H., & Li, J. (2023) · European Journal of Medical Research · doi:10.1186/s40001-023-01287-0 · Cited by 10
Wang, Y., Sun, Y., Tang, J., Zhou, W., Liu, X., Bi, Y., & Zhang, Z.-J. (2018) · Annals of Epidemiology · doi:10.1016/j.annepidem.2018.11.010 · Cited by 10
Self-citationMetformina: más allá del control glucémico
de Colombia, U. N., Morantes-Caballero, J. A., Londoño-Zapata, G. A., de Colombia, U. N., Rivera, M. R., de Colombia, U. N., Pinilla-Roa, A. E., & de Colombia, U. N. (2017) · Revista Médicas UIS · doi:10.18273/revmed.v30n1-2017005 · Cited by 9
Yue, N., Jia, F., Du, X., & Mei, Z. (2020) · International Journal of Surgery · doi:10.1016/j.ijsu.2020.02.041 · Cited by 7
Bosco, C. (2015) · ecancermedicalscience · doi:10.3332/ecancer.2015.555 · Cited by 8
Wang, Z., Li, J., Wang, L., Liu, Y., Wang, W., Chen, J., Liang, H., Chen, Y. Q., & Zhu, S. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00535-3 · Cited by 7
Zhang, Z.-J. (2019) · Journal of General Internal Medicine · doi:10.1007/s11606-019-04982-z · Cited by 7
Self-citationWang, Y., Hu, J., Sun, Y. L., Song, B., Zhang, Y., Lu, Y., & Ma, H. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/5983959 · Cited by 7
RetractedCancer Prevention Strategies for Women
Tergas, A. I., & Wright, J. D. (2019) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000003304 · Cited by 7
Wei, M., Liu, Y., Wang, C., Yu, C., Li, D., Zhou, W., & Zhang, Z.-J. (2016) · Acta Diabetologica · doi:10.1007/s00592-016-0948-8 · Cited by 7
Self-citationWei, M., Liu, Y., Wang, C., Yu, C., Li, D., Zhou, W., & Zhang, Z.-J. (2016) · Acta Diabetologica · doi:10.1007/s00592-016-0933-2 · Cited by 7
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Katić, L., Choi, J. W., Saravia, S. D., Silverman, A., Nagourney, A., Torelli, V. A., Gupta, S., Glavan, M., Gulati, A., Khurana, S., et al. (2024) · Cureus · doi:10.7759/cureus.62953 · Cited by 6
Wang, Y., Fu, T., Liu, Y., Yang, G., Yu, C., & Zhang, Z.-J. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200218095310 · Cited by 6
Self-citationWang, Y., Liu, X., Yan, P., Bi, Y., Liu, Y., & Zhang, Z.-J. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190716113126 · Cited by 6
Self-citationSchmedt, N., Azoulay, L., & Hense, S. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwu311 · Cited by 6
Phenformin Induces Caspase-dependent Apoptosis of FaDu Head and Neck Squamous Cell Carcinoma Cells
Seo, Y., Kim, T. H., Lim, H., Oh, J.-S., You, J., Lee, G., Yu, S., Kim, D. K., KIM, H.-J., KIM, C. S., et al. (2019) · Anticancer Research · doi:10.21873/anticanres.13496 · Cited by 5
Hense, H. W., & Geier, A. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwu296 · Cited by 5
Zhang, Z.-J. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwu297 · Cited by 5
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Metadata
- Authors
- Zhang, Z.-J., Bi, Y., Li, S., Zhang, Q., Zhao, G., Guo, Y., & Song, Q.
- Affiliations
- Wuhan University (CN)
- Wuhan Donghu University (CN)
- Corresponding author
- Zhang, Zhi-Jiang
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-06-10
- Volume
- 180
- Issue
- 1
- Pages
- 11-14
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W3145105062
- Cited by
- 120
- References
- 28
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 14 · 2023: 9 · 2022: 6 · 2021: 7 · 2020: 8 · 2019: 19 · 2018: 11 · 2017: 14 · 2016: 9 · 2015: 12 · 2014: 5
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- metformin, lung cancer, respiratory cancer, diabetes mellitus, cancer risk, smoking adjustment, heterogeneity
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Lung Neoplasms, Metformin, Risk, Risk Factors, Smoking
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