Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions

Hallmarks of Cancer: The Next Generation

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mTOR Signaling in Growth Control and Disease

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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

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Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

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mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

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Tumor cell metabolism: cancer's Achilles' heel

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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

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Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

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Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

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Autophagy and Metabolism

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

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Serine, glycine and one-carbon units: cancer metabolism in full circle

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A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

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Cancer cachexia: understanding the molecular basis

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Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

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Methionine metabolism in mammals

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Cancer and the microbiota

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Reductive carboxylation supports growth in tumour cells with defective mitochondria

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Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.

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Targeting lactate metabolism for cancer therapeutics

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Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells

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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

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Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

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The insulin and insulin-like growth factor receptor family in neoplasia: an update

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Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer

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Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

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Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3

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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

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Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population

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Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy

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A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan

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Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials

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The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

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Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer

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Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

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Metabolic Modulation of Glioblastoma with Dichloroacetate

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Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy

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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

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Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells

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Arginine Metabolism: Boundaries of Our Knowledge

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Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

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Caloric restriction mimetics enhance anticancer immunosurveillance

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Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo

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Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery

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IDH mutations in cancer and progress toward development of targeted therapeutics

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Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning

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The pharmacology of dichloroacetate

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Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression

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Tumours with PI3K activation are resistant to dietary restriction

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Long-Term Metformin Use Is Associated With Decreased Risk of Breast Cancer

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Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer

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Detection of 2-Hydroxyglutarate in <i>IDH</i> -Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy

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Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation

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Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

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Standing the test of time: targeting thymidylate biosynthesis in cancer therapy

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Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial

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Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

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Calorie restriction and cancer prevention: metabolic and molecular mechanisms

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ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

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Impact of Diabetes Mellitus on Outcomes in Patients With Colon Cancer

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Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer.

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SLC1A5 Mediates Glutamine Transport Required for Lung Cancer Cell Growth and Survival

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Metabolism of [U‐ ¹³ C]glucose in human brain tumors <i>in vivo</i>

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The metabolic basis of arginine nutrition and pharmacotherapy

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Inhibition of fatty acid synthase (FAS) suppresses HER2/neu ( erb B-2) oncogene overexpression in cancer cells

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