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Cited by 101Mindfulness and Compassion InterventionsBlood Pressure and Hypertension StudiesSodium Intake and Health

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Hypertension Analysis of Stress Reduction Using Mindfulness Meditation and Yoga: Results From the Harmony Randomized Controlled Trial

Blom, K., Baker, B., How, M., Dai, M., Irvine, J., Abbey, S., Abramson, B. L., Myers, M. G., Kiss, A., Perkins, N. J., Tobe, S. W.·2014·American Journal of Hypertension
DOI 10.1093/ajh/hpt134
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Abstract

BACKGROUND: The HARMONY study was a randomized, controlled trial examining the efficacy of an 8-week mindfulness-based stress reduction (MBSR) program for blood pressure (BP) lowering among unmedicated stage 1 hypertensive participants. METHODS: Participants diagnosed with stage 1 hypertension based on ambulatory BP were randomized to either immediate treatment of MBSR for 8 weeks or wait-list control. Primary outcome analysis evaluated whether change in awake and 24-hour ambulatory BP from baseline to week 12 was significantly different between the 2 groups. A within-group before and after MBSR analysis was also performed. RESULTS: The study enrolled 101 adults (38% male) with baseline average 24-hour ambulatory BP of 135±7.9/82±5.8mm Hg and daytime ambulatory BP of 140±7.7/87±6.3 mmHg. At week 12, the change from baseline in 24-hour ambulatory BP was 0.4±6.7/0.0±4.9mm Hg for the immediate intervention and 0.4±7.8/-0.4±4.6mm Hg for the wait-list control. There were no significant differences between intervention and wait-list control for all ambulatory BP parameters. The secondary within-group analysis found a small reduction in BP after MBSR compared with baseline, a finding limited to female subjects in a sex analysis. CONCLUSIONS: MBSR did not lower ambulatory BP by a statistically or clinically significant amount in untreated, stage 1 hypertensive patients when compared with a wait-list control group. It leaves untested whether MBSR might be useful for lowering BP by improving adherence in treated hypertensive participants. CLINICAL TRIALS REGISTRATION: NCT00825526.

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  1. Wilkins, 2010, Health reports / Statistics Canada, Canadian Centre for Health Information = Rapports sur la sant / Statistique Canada, Centre canadien d'information sur la sant , 21, 37
  2. 2012, BMJ, 344, d8262

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Metadata

Authors
Blom, K., Baker, B., How, M., Dai, M., Irvine, J., Abbey, S., Abramson, B. L., Myers, M. G., Kiss, A., Perkins, N. J., & Tobe, S. W.
Affiliations
  • Sunnybrook Health Science Centre (CA)
  • University Health Network (CA)
  • York University (CA)
  • University of Toronto (CA)
  • Institute for Clinical Evaluative Sciences (CA)
ORCID
Venue
American Journal of Hypertension
Publisher
Oxford University Press (OUP)
Published
2013-09-14
Volume
27
Issue
1
Pages
122-129
ISSN
  • 0895-7061 (ISSN-L)
  • 1941-7225
DOI
10.1093/ajh/hpt134
OpenAlex
W2014081470
Cited by
101
References
43
Citations by year
2026: 3 · 2025: 6 · 2024: 10 · 2023: 2 · 2022: 12 · 2021: 9 · 2020: 13 · 2019: 10 · 2018: 9 · 2017: 10 · 2016: 5 · 2015: 8 · 2014: 3 · 2013: 1
FWCI
6.30
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Funders
Heart and Stroke Foundation of Canada
Topics
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Keywords
mindfulness-based stress reduction, hypertension, stage 1 hypertension, ambulatory blood pressure, yoga, blood pressure reduction, waitlist control, sex differences
MeSH terms
Adult, Aged, Blood Pressure, Female, Humans, Hypertension, Male, Middle Aged, Stress, Psychological, Time Factors, Yoga, Treatment Outcome, Blood Pressure Monitoring, Ambulatory, Meditation, Mindfulness

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