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Cited by 535

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FRONTAL LOBE CHANGES IN ALCOHOLISM: A REVIEW OF THE LITERATURE

Open access
Moselhy, H. F.·2001·Alcohol and Alcoholism

Abstract

Alcohol can induce a wide spectrum of effects on the central nervous system. These effects can be recognized at the neurophysiological, morphological and neuropsychological levels. Several studies of the effect of alcohol on the frontal lobes were identified for review from MedLine, PsychLIT databases and by manual searching. In this review article, the different changes are examined in detail. Computed tomography studies have reported changes of frontal lobe in alcoholism, while magnetic resonance imaging studies supported these findings. Neurophysiological studies with positron emission tomography and single photon emission computed tomography have reported a decreased frontal lobe glucose utilization and reduced cerebral blood flow. There is also evidence from neuropsychological studies that there are specific deficits in alcoholism that suggest frontal lobe dysfunction. Considered together, these studies lend a strong credence to the concept of frontal lobe pathology in alcoholism. However, frontal lobe is not an isolated part of the brain and should be considered with its heavy connections to different cortical and subcortical areas of the brain.

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Metadata

Authors
Moselhy, H. F.
Venue
Alcohol and Alcoholism
Published
2001-09-01
Volume
36
Issue
5
Pages
357-368
ISSN
  • 0735-0414 (ISSN-L)
  • 1464-3502
OpenAlex
W2143242859
Cited by
535
References
4
FWCI
9.27
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: FRONTAL LOBE CHANGES IN ALCOHOLISM: A REVIEW OF THE LITERATURE. https://app.cochat.ai/papers/10.1093/alcalc/36.5.357
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Moselhy, H. F. (2001). FRONTAL LOBE CHANGES IN ALCOHOLISM: A REVIEW OF THE LITERATURE. Alcohol and Alcoholism. https://doi.org/10.1093/alcalc/36.5.357

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