The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
PHOSPHATIDYLETHANOL (PEth) CONCENTRATIONS IN BLOOD ARE CORRELATED TO REPORTED ALCOHOL INTAKE IN ALCOHOL-DEPENDENT PATIENTS
Open accessAbstract
AIMS: Phosphatidylethanol (PEth) is an abnormal phospholipid formed only in the presence of ethanol by the enzyme phospholipase D. PEth in blood is a promising new marker for ethanol abuse. None of the biological markers used at the present time is sensitive and specific enough for the diagnosis of alcoholism. METHODS: The most frequently used alcohol markers [carbohydrate deficient transferrin (CDT), gamma-glutamyltransferase (GGT), and mean corpuscular volume (MCV)] were studied together with PEth in actively drinking alcohol-dependent patients (inpatients and outpatients), with regard to correlation to ethanol intake and diagnostic sensitivity of the markers. The relation between the markers was also studied. RESULTS: PEth, CDT, and GGT correlated to ethanol intake, with the strongest correlation found for PEth. The diagnostic sensitivity for PEth was 99%, and for other markers it varied between 40 and 77%. Only when CDT was combined with GGT was a sensitivity of 94% reached. PEth correlated to CDT and GGT but not to MCV. CDT did not correlate to GGT or MCV. CONCLUSIONS: Blood concentrations of PEth are highly correlated to ethanol intake, and the present results indicate that its diagnostic sensitivity is higher than that for previously established alcohol markers.
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Cites
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Self-citationImproved HPLC Method for Carbohydrate-deficient Transferrin in Serum
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Cited by
Walther, L., de Bejczy, A., Löf, E., Hansson, T., Andersson, A., Guterstam, J., Hammarberg, A., Asanovska, G., Franck, J., Söderpalm, B., et al. (2015) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.12883 · Cited by 112
Self-citationHahn, J. A., Emenyonu, N. I., Fatch, R., Muyindike, W. R., Kekiibina, A., Carrico, A. W., Woolf‐King, S., & Shiboski, S. (2016) · Addiction · doi:10.1111/add.13173 · Cited by 97
Hahn, J. A., Murnane, P. M., Vittinghoff, E., Muyindike, W. R., Emenyonu, N. I., Fatch, R., Chamie, G., Haberer, J. E., Francis, J. M., Kapiga, S., et al. (2021) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.14611 · Cited by 87
Ferguson, T. F., Theall, K. P., Brashear, M., Maffei, V., Beauchamp, A., Siggins, R. W., Simon, L., Mercante, D., Nelson, S., Welsh, D. A., et al. (2020) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.14336 · Cited by 26
Metadata
- Authors
- ARADOTTIR, S., ASANOVSKA, G., GJERSS, S., HANSSON, P., & ALLING, C.
- Venue
- Alcohol and Alcoholism
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-04-19
- Volume
- 41
- Issue
- 4
- Pages
- 431-437
- ISSN
- 0735-0414 (ISSN-L)
- 1464-3502
- OpenAlex
- W2134319366
- Cited by
- 256
- References
- 24
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: PHOSPHATIDYLETHANOL (PEth) CONCENTRATIONS IN BLOOD ARE CORRELATED TO REPORTED ALCOHOL INTAKE IN ALCOHOL-DEPENDENT PATIENTS. https://app.cochat.ai/papers/10.1093/alcalc/agl027
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- ARADOTTIR, S., ASANOVSKA, G., GJERSS, S., HANSSON, P., & ALLING, C. (2006). PHOSPHATIDYLETHANOL (PEth) CONCENTRATIONS IN BLOOD ARE CORRELATED TO REPORTED ALCOHOL INTAKE IN ALCOHOL-DEPENDENT PATIENTS. Alcohol and Alcoholism. https://doi.org/10.1093/alcalc/agl027
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