RCT of effectiveness of motivational enhancement therapy delivered by nurses for hazardous drinkers in primary care units in Thailand
Open accessAbstract
AIMS: To determine the effectiveness of Motivational Enhancement Therapy (MET) for hazardous drinkers in Primary Care Unit (PCU) settings in rural Thailand. METHODS: A randomized controlled trial was conducted in eight PCUs in Ubonratchatanee and Chachoengsao provinces in Thailand. Hazardous drinkers were identified using the World Health Organization-recommended Alcohol Use Disorder Identification Test. Of 117 eligible participants (91% male), 59 were randomized to the intervention group to receive MET in three individual appointments with a trained nurse and 58 to an assessment-only control group. Outcome evaluations were carried out after 6 weeks, 3 months and 6 months. RESULTS: Follow-up data were available on 84, 94 and 91% of subjects, respectively, at the three intervals. Self-reported drinks per drinking day, frequency of hazardous drinking assessed either on a daily or weekly basis, and of binge drinking sessions were reduced in the intervention group more than in the control group (P < 0.05) after both 3 and 6 months. The groups did not generally differ at 6 weeks. However, although self-reported consumption in both groups fell from baseline to 6-month follow-up, serum gamma-glutamyl transferase increased in both groups, which raises doubts about the validity of this marker in this sample and/or the validity of the self-reported data in this study. CONCLUSION: MET delivered by nurses in PCUs in Thailand appears to be an effective intervention for male hazardous drinkers. Uncertainties about the validity of self-reported data jeopardize the safety of this conclusion.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Seven studies compared brief intervention to no or minimal intervention and reported gamma-glutamyltransferase (GGT).
“We included seven studies that compared brief intervention to no or minimal intervention and reported gamma-glutamyltransferase (GGT) (Aalto 2000;Beckham 2007;Noknoy 2010;Romelsjö 1989;Scott 1990;Tomson 1998;Wallace 1988).”
From Effectiveness of brief alcohol interventions in primary care populations (2018) · cites this paper as Noknoy 2010
Lay counselor-delivered brief interventions had significant differences between intervention and control.
“Other modes of delivery revealed that lay counselor–delivered interventions had significant differences between intervention and control [67,71,75]”
From Patient-level interventions to reduce alcohol-related harms in low- and middle-income countries: A systematic review and meta-summary (2022) · cites this paper as [75]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
SAUNDERS, J. B., AASLAND, O. G., BABOR, T. F., DE LA FUENTE, J. R., & GRANT, M. (1993) · Addiction · doi:10.1111/j.1360-0443.1993.tb02093.x · Cited by 13,482 · see citing works
(1991) · Medical Entomology and Zoology · Cited by 4,438 · see citing works
Effectiveness of brief alcohol interventions in primary care populations
Kaner, E. F., Beyer, F. R., Muirhead, C., Campbell, F., Pienaar, E. D., Bertholet, N., Daeppen, J. B., Saunders, J. B., & Burnand, B. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004148.pub4 · Cited by 1,665 · see citing works
Moyer, A., Finney, J. W., Swearingen, C. E., & Vergun, P. (2002) · Addiction · doi:10.1046/j.1360-0443.2002.00018.x · Cited by 1,092 · cited 1× · see citing works
“This may be partly explained by the shorter study period used here (Moyer et al., 2002), although there was no substantial evidence of any deterioration in effect over time.”
MethodEffectiveness of brief alcohol interventions in primary care populations
Kaner, E. F. S., Dickinson, H. O., Beyer, F. R., Campbell, F., Schlesinger, C., Heather, N., Saunders, J. B., Burnand, B., & Pienaar, E. D. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004148.pub3 · Cited by 746 · see citing works
Bertholet, N. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.9.986 · Cited by 710 · see citing works
Meta-analysis of Randomized Control Trials Addressing Brief Interventions in Heavy Alcohol Drinkers
Wilk, A. I., Jensen, N. M., & Havighurst, T. C. (1997) · Journal of General Internal Medicine · doi:10.1007/s11606-006-5063-z · Cited by 577 · see citing works
Reducing harm from alcohol: call to action
Casswell, S., & Thamarangsi, T. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60745-5 · Cited by 294 · see citing works
Poikolainen, K. (1999) · Preventive Medicine · doi:10.1006/pmed.1999.0467 · Cited by 211 · see citing works
Sellman, J. D., Sullivan, P. F., Dore, G. M., Adamson, S. J., & MacEwan, I. (2001) · Journal of Studies on Alcohol · doi:10.15288/jsa.2001.62.389 · Cited by 121 · see citing works
Outcome studies of brief alcohol intervention in general practice: the problem of lost subjects.
Edwards, A., & Rollnick, S. (1997) · PubMed · Cited by 114 · see citing works
Outcome studies of brief alcohol intervention in general practice: the problem of lost subjects
EDWARDS, A. G. K., & ROLLNICK, S. (1997) · Addiction · doi:10.1111/j.1360-0443.1997.tb02890.x · Cited by 93 · see citing works
Effectiveness of nurse-led brief alcohol intervention: a cluster randomized controlled trial
Lock, C. A., Kaner, E., Heather, N., Doughty, J., Crawshaw, A., McNamee, P., Purdy, S., & Pearson, P. (2006) · Journal of Advanced Nursing · doi:10.1111/j.1365-2648.2006.03836.x · Cited by 81 · see citing works
Holloway, A. S., Watson, H. E., Arthur, A. J., Starr, G., McFadyen, A. K., & McIntosh, J. (2007) · Addiction · doi:10.1111/j.1360-0443.2007.01968.x · Cited by 54 · see citing works
Motivational interviewing with hazardous drinkers
Beckham, N. (2007) · Journal of the American Academy of Nurse Practitioners · doi:10.1111/j.1745-7599.2006.00200.x · Cited by 44 · see citing works
Prevalence of hazardous—harmful drinking in a southern Thai community
Assanangkornchai, S., PINKAEW, P., & Apakupakul, N. (2003) · Drug and Alcohol Review · doi:10.1080/0959523031000154427 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Effectiveness of brief alcohol interventions in primary care populations
Kaner, E. F., Beyer, F. R., Muirhead, C., Campbell, F., Pienaar, E. D., Bertholet, N., Daeppen, J. B., Saunders, J. B., & Burnand, B. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004148.pub4 · Cited by 1,665 · see citing works
Lundahl, B., Moleni, T., Burke, B. L., Butters, R., Tollefson, D., Butler, C., & Rollnick, S. (2013) · Patient Education and Counseling · doi:10.1016/j.pec.2013.07.012 · Cited by 909 · see citing works
van Ginneken, N., Tharyan, P., Lewin, S., Rao, G. N., Meera, S., Pian, J., Chandrashekar, S., & Patel, V. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009149.pub2 · Cited by 575 · see citing works
Jonas, D. E., Garbutt, J. C., Amick, H. R., Brown, J. M., Brownley, K. A., Council, C. L., Viera, A. J., Wilkins, T. M., Schwartz, C. J., Richmond, E. M., et al. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-9-201211060-00544 · Cited by 387 · see citing works
Nadkarni, A., Weobong, B., Weiss, H. A., McCambridge, J., Bhat, B., Katti, B., Murthy, P., King, M., McDaid, D., Park, A.-L., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(16)31590-2 · Cited by 187 · see citing works
Self-citationPlatt, L., Melendez-Torres, G. J., O'Donnell, A., Bradley, J., Newbury-Birch, D., Kaner, E., & Ashton, C. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-011473 · Cited by 136 · see citing works
Peltzer, K., Naidoo, P., Louw, J., Matseke, G., Zuma, K., Mchunu, G., Tutshana, B., & Mabaso, M. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-699 · Cited by 82 · see citing works
Bendtsen, M., McCambridge, J., Åsberg, K., & Bendtsen, P. (2021) · Addiction · doi:10.1111/add.15294 · Cited by 71 · see citing works
Self-citationPengpid, S., Peltzer, K., Van der Heever, H., & Skaal, L. (2013) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph10052043 · Cited by 63 · see citing works
Elzerbi, C., Donoghue, K., & Drummond, C. (2015) · Addiction · doi:10.1111/add.12960 · Cited by 64 · see citing works
Motivational interviewing for substance use reduction
Schwenker, R., Dietrich, C. E., Hirpa, S., Nothacker, M., Smedslund, G., Frese, T., & Unverzagt, S. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008063.pub3 · Cited by 56 · see citing works
Joseph, J., & Basu, D. (2017) · Alcohol and Alcoholism · doi:10.1093/alcalc/agw054 · Cited by 52 · see citing works
Pengpid, S., Peltzer, K., Skaal, L., & Van der Heever, H. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-644 · Cited by 49 · see citing works
Closing the treatment gap for alcohol use disorders in low- and middle-income countries
Nadkarni, A., Gandhi, Y., Bhatia, U., & Velleman, R. (2023) · Cambridge Prisms: Global Mental Health · doi:10.1017/gmh.2022.57 · Cited by 46 · see citing works
Staton, C. A., Vissoci, J. R. N., El-Gabri, D., Adewumi, K., Concepcion, T., Elliott, S. A., Evans, D. R., Galson, S. W., Pate, C. T., Reynolds, L. M., et al. (2022) · PLOS Medicine · doi:10.1371/journal.pmed.1003961 · Cited by 41 · see citing works
Preusse, M., Neuner, F., & Ertl, V. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00768 · Cited by 38 · see citing works
Fifty years of brief intervention effectiveness trials for heavy drinkers: Editorial
McCAMBRIDGE, J. (2011) · Drug and Alcohol Review · doi:10.1111/j.1465-3362.2011.00379.x · Cited by 24 · see citing works
Self-citationNadkarni, A., Weiss, H. A., Velleman, R., McCambridge, J., McDaid, D., Park, A., Murthy, P., Weobong, B., Bhat, B., & Patel, V. (2019) · Addiction · doi:10.1111/add.14630 · Cited by 22 · see citing works
Self-citationPengpid, S., Peltzer, K., Puckpinyo, A., Viripiromgool, S., Thamma-aphiphol, K., Suthisukhon, K., Dumee, D., & Kongtapan, T. (2015) · Substance Abuse Treatment, Prevention, and Policy · doi:10.1186/s13011-015-0018-1 · Cited by 16 · see citing works
Greene, M. C., Kane, J., Alto, M., Giusto, A., Lovero, K., Stockton, M., McClendon, J., Nicholson, T., Wainberg, M. L., Johnson, R. M., et al. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013350.pub2 · Cited by 11 · see citing works
Zhang, B., Zhang, R., Deng, H., Cui, P., Li, C., Yang, F., & Leong Bin Abdullah, M. F. I. (2023) · PLoS ONE · doi:10.1371/journal.pone.0294768 · Cited by 6 · see citing works
Effects of the Phramongkutklao model on alcohol-dependent patient: a randomized controlled trial
Daengthoen, L., Saengcharnchai, P., Yingwiwattanapong, J., & Perngparn, U. (2014) · Journal of Substance Use · doi:10.3109/14659891.2012.734543 · Cited by 5 · see citing works
Self-citationDeng, H., Zhang, R., Wang, C., Zhang, B., Wang, J., Wang, S., Zhang, J., Shari, N. I., & Leong Bin Abdullah, M. F. I. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1215963 · Cited by 5 · see citing works
“week or three drinks per drinking days for women) (37).”
BackgroundHanpatchaiyakul, K., Eriksson, H., Kijsomporn, J., & Östlund, G. (2016) · Global Health Action · doi:10.3402/gha.v9.31738 · Cited by 2 · see citing works
- Authors
- Noknoy, S., Rangsin, R., Saengcharnchai, P., Tantibhaedhyangkul, U., & McCambridge, J.
- Affiliations
- Chonburi Hospital (TH)
- Phramongkutklao College of Medicine (TH)
- Phramongkutklao Hospital (TH)
- London School of Hygiene & Tropical Medicine (GB)
- Corresponding author
- Noknoy, S.
- Venue
- Alcohol and Alcoholism
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-03-17
- Volume
- 45
- Issue
- 3
- Pages
- 263-270
- ISSN
- 0735-0414 (ISSN-L)
- 1464-3502
- PMC
- PMC4394355
- OpenAlex
- W2159727555
- Cited by
- 64
- References
- 16
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 6 · 2016: 8 · 2015: 6 · 2014: 4 · 2013: 9 · 2012: 5
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alcohol and Alcoholism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
- Funders
- Wellcome Trust (086516)
- Thai Health Promotion Foundation
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Social Sciences › Psychology › Applied Psychology › Behavioral Health and Interventions
- Keywords
- motivational enhancement therapy, hazardous drinking, primary care units, rural Thailand, binge drinking, alcohol consumption reduction, serum gamma-glutamyltransferase
- MeSH terms
- Adolescent, Adult, Aged, Alcoholism, Double-Blind Method, Female, Follow-Up Studies, gamma-Glutamyltransferase, Humans, Male, Middle Aged, Motivation, Nurses, Primary Health Care, Psychiatric Status Rating Scales, Psychotherapy, Thailand, Biomarkers, Health Behavior, Treatment Outcome, Sample Size, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
