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Cited by 48Substance Abuse Treatment and OutcomesSleep and related disordersAlcoholism and Thiamine Deficiency

Sleep disturbance in alcoholism: proposal of a simple measurement, and results from a 24-week randomized controlled study of alcohol-dependent patients assessing acamprosate efficacy

Perney, Pascal, Lehert, Philippe, Mason, Barbara J·2012·Alcohol and Alcoholism
DOI 10.1093/alcalc/agr160
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Abstract

AIMS: Sleep disturbance symptom (SDS) is commonly reported in alcoholic patients. Polysomnography studies suggested that acamprosate decreased SDS. We assessed this hypothesis by using data of a randomized controlled trial. As a secondary objective, we suggested and tested the validity of a simple measurement of SDS based on the Hamilton depression and anxiety inventory subset. METHODS: We re-analysed a multi-center study evaluating the efficacy of acamprosate compared with placebos on alcohol-dependent patients in concentrating on SDS change in time. The Sleep sum score index (SAEI) was built from check-lists on adverse effects reported at each visit and constituted our main endpoint. We also tested the validity of the short sleep index (SSI) defined by the four sleep items of the Hamilton depression and anxiety scales. Statistical analyses were conducted on an intention to treat basis. RESULTS: A total of 592 patients were included, and 292 completed the 6-month trial. Compared with SAEI considered as our reference, the observed specificity and sensitivity of SSI were 91.6 and 87.6%. From 40.2% of patients experiencing SDS at baseline, this proportion decreased until 26.1% at M6 in the placebo group and 19.5% in the acamprosate group (relative risk placebo/acamprosate = 1.49, 95% confidence interval 1.10, 1.98, P = 0.04). CONCLUSION: Treating alcoholic patients to enhance abstinence has a beneficial effect in reducing SDS, and the duration of abstinence during the treatment constitutes the main positive factor. An additional effect of acamprosate is conjectured from its effect on the glutamatergic tone. The SSI constitutes a simple, reasonably sensitive and specific instrument tool to measure SDS.

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  • Acamprosate blocked sleep disturbances associated with protracted abstinence in humans.

    “Acamprosate also blocked sleep disturbances that were associated with protracted abstinence in humans (Perney et al., 2012), again linking its therapeutic actions to the reversal of hyperkatifeia.”

    From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Perney et al., 2012

    The Discussion (page unavailable) reports that acamprosate improved sleep disturbances more quickly than placebo after alcohol withdrawal, with a significant benefit over six months. The Conclusion (page unavailable) also describes improved sleep problems, but neither passage says acamprosate blocked or prevented the disturbances; the paper describes a smaller improvement after accounting for abstinence duration. (LLM, conf=0.86)

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Authors
Perney, P., Lehert, P., & Mason, B. J.
Affiliations
  • Université Montpellier 1 (FR)
  • UCLouvain (BE)
  • Scripps Research Institute (US)
Corresponding author
Perney, Pascal
ORCID
Venue
Alcohol and Alcoholism
Publisher
Oxford University Press (OUP)
Published
2012-01-04
Volume
47
Issue
2
Pages
133-139
ISSN
  • 0735-0414 (ISSN-L)
  • 1464-3502
DOI
10.1093/alcalc/agr160
OpenAlex
W2147178707
Cited by
48
References
42
Citations by year
2025: 4 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 2 · 2013: 3 · 2012: 2
FWCI
3.10
Type
journal article
Language
en
Open access
closed
Locations
  • Alcohol and Alcoholism (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Libraries (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
Keywords
sleep disorders, alcoholism, acamprosate, abstinence duration, adverse effects
MeSH terms
Acamprosate, Adult, Alcohol Deterrents, Alcoholism, Female, Humans, Male, Middle Aged, Sensitivity and Specificity, Severity of Illness Index, Sleep Wake Disorders, Taurine

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