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Cited by 223Substance Abuse Treatment and OutcomesSleep and related disordersSleep and Wakefulness Research

Polysomnographic and subjective sleep predictors of alcoholic relapse

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Brower, Kirk J., Aldrich, Michael S., Hall, Janette M.·1998·Alcoholism Clinical and Experimental Research
DOI 10.1111/j.1530-0277.1998.tb03995.x
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Abstract

Previous studies indicate that subjectively reported and objectively measured sleep abnormalities at baseline can increase the risk of relapse in treated alcoholics. However, previous studies did not include both subjective and objective sleep measures in the same group of patients. We utilized polysomnography and the Sleep Disorders Questionnaire to determine if baseline polysomnography increased the ability to predict relapse beyond the prediction with subjective measures alone, after controlling for nonsleep variables that were associated with relapse. We followed 74 patients with a DSM-III-R diagnosis of alcohol dependence, of whom 36 relapsed to at least some drinking during an average follow-up interval of 5 months. Univariate analyses revealed that relapsed patients did not differ from abstinent patients at baseline in demographics or psychiatric co-morbidity, but they had more prior treatment episodes for alcoholism, more difficulty falling asleep, more complaints of abnormal sleep, and, on polysomnography, longer sleep latencies, shorter rapid eye movement sleep latencies, and less stage 4 sleep percentage than abstinent patients. With a series of logistic regression analyses, which controlled for age and gender, we demonstrated that sleep measures improved the prediction model compared with nonsleep variables alone, and that polysomnography-measured sleep latency was the most significant predictor variable. We conclude that subjective and objective measures of baseline sleep are predictors of relapse in treated alcoholic patients. These data also suggest that neurophysiological dysfunction contributes strongly to the etiology of relapse. Finally, sleep disturbance warrants clinical attention as a target of alcoholism treatment.

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  • Persistent symptoms of insomnia during abstinence from alcohol confer an increased risk of relapse in adults in remission from AUDs.

    “Finally, several studies have reported that persistent symptoms of insomnia during abstinence from alcohol confer an increased risk of relapse in adults in remission from AUDs (Brower, Aldrich, & Hall, 1998; Brower, Aldrich, Robinson, Zucker, & Greden, 2001; Drummond, Gillin, Smith, & DeModena, 1998).”

    From Sleep and circadian contributions to adolescent alcohol use disorder (2015) · cites this paper as Brower et al., 1998

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Authors
Brower, K. J., Aldrich, M. S., & Hall, J. M.
Affiliations
University of Michigan (US)
ORCID
Brower, Kirk J.
Venue
Alcoholism Clinical and Experimental Research
Publisher
Wiley
Published
1998-11
Volume
22
Issue
8
Pages
1864-1871
ISSN
  • 0145-6008 (ISSN-L)
  • 1530-0277
DOI
10.1111/j.1530-0277.1998.tb03995.x
OpenAlex
W2055930578
Cited by
223
References
32
Citations by year
2026: 3 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 15 · 2021: 8 · 2020: 7 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 11 · 2015: 14 · 2014: 13 · 2013: 12 · 2012: 10
FWCI
4.63
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2767 d)
Locations
  • Alcoholism Clinical and Experimental Research (publishedVersion)
  • PubMed (publishedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
Funders
National Institute on Alcohol Abuse and Alcoholism (5-P50 AA07378, P50AA007378)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
alcohol relapse, alcoholism, sleep disorders, polysomnography, sleep latency, REM latency, stage 4 sleep, subjective sleep complaints, recurrence prediction, alcoholism treatment
MeSH terms
Adult, Alcoholism, Female, Follow-Up Studies, Humans, Male, Middle Aged, Patient Admission, Recurrence, Risk, Sleep Wake Disorders, Sleep Stages, Polysomnography

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