Clinical biopsychosocial risk factors for depression in lung cancer patients: a comprehensive analysis using data from the Lung Cancer Database Project
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Background Various risk factors for depression in lung cancer patients have been suggested but have been examined separately in studies with relatively small sample sizes. The present study examined the biopsychosocial risk factors of depression in lung cancer patients, focusing on psychological factors in the largest patient sample reported to date.Patients and methods A total of 1334 consecutively recruited lung cancer patients were selected, and data on cancer-related variables, personal characteristics, health behaviors, physical symptoms, and psychological factors were obtained. The participants were divided into groups with or without depression using the Hospital Anxiety and Depression Scale.Results Among the recruited patients, 165 (12.4%) manifested depression. The results of a binary logistic regression analysis were significant (overall R2, 36.5%), and a greater risk for depression was strongly associated with psychological factors, such as personality characteristics (neuroticism) and coping style (low fighting spirit, helplessness/hopelessness, and anxious preoccupation). Although the contributions of cancer-related variables, personal characteristics, health behaviors, and clinical state were relatively low, cancer stage, cancer type, sex, and age correlated significantly with depression.Conclusion Depression was most strongly linked with personality traits and coping style, and using screening instruments to identify these factors may be useful for preventive interventions.
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Hope is negatively associated with depression, anxiety, and psychological distress among cancer patients.
“For instance, hope is negatively associated with depression, anxiety, and psychological distress among cancer patients [19–22].”
From Acceptance and commitment therapy versus mindfulness-based stress reduction for newly diagnosed head and neck cancer patients: A randomized controlled trial assessing efficacy for positive psychology, depression, anxiety, and quality of life (2022) · cites this paper as [20]
The Results (t, Mann-Whitney, and χ² tests; page unavailable) report that depressed lung cancer patients scored higher on helplessness/hopelessness, supporting the depression portion indirectly. The paper measured coping styles and depression, not hope as a separate construct or anxiety and psychological distress as outcomes; it also studied lung cancer patients rather than cancer patients generally. (LLM, conf=0.88)
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- Authors
- Shimizu, K., Nakaya, N., Saito-Nakaya, K., Akechi, T., Yamada, Y., Fujimori, M., Ogawa, A., Fujisawa, D., Goto, K., Iwasaki, M., Tsugane, S., & Uchitomi, Y.
- Affiliations
- National Cancer Center Hospital (JP)
- Tohoku University (JP)
- Nagoya City University (JP)
- National Cancer Center Hospital East (JP)
- National Cancer Center Research Institute (JP)
- Okayama University (JP)
- Corresponding author
- Shimizu, K.
- ORCID
- Venue
- Annals of Oncology
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 23
- Issue
- 8
- Pages
- 1973-1979
- ISSN
- 0923-7534 (ISSN-L)
- OpenAlex
- W2104490972
- Cited by
- 53
- References
- 55
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 7 · 2019: 2 · 2018: 1 · 2017: 6 · 2016: 5 · 2015: 9 · 2014: 6 · 2013: 3 · 2012: 1
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Annals of Oncology (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Clinical Cancer Research (H22-033, H22-036)
- Japanese Ministry of Health, Labor and Welfare
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- depression, lung cancer, biopsychosocial risk factors, psychological factors, neuroticism, coping styles, helplessness, anxious preoccupation, fighting spirit, personality traits, tumor stage, depression screening
- MeSH terms
- Adaptation, Psychological, Adult, Aged, Aged, 80 and over, Depression, Female, Humans, Japan, Lung Neoplasms, Male, Middle Aged, Quality of Life, Risk Factors, Social Class, Logistic Models
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