Preference for subcutaneous or intravenous administration of rituximab among patients with untreated CD20+ diffuse large B-cell lymphoma or follicular lymphoma: results from a prospective, randomized, open-label, crossover study (PrefMab)

Rummel, M.; Kim, T.M.; Aversa, F.; Brugger, W.; Capochiani, E.; Plenteda, C.; Re, F.; Trask, P.; Osborne, S.; Smith, R.; Grigg, A.

doi:10.1093/annonc/mdw685

Cited by 154Lymphoma Diagnosis and TreatmentChronic Lymphocytic Leukemia ResearchNeutropenia and Cancer Infections

Preference for subcutaneous or intravenous administration of rituximab among patients with untreated CD20+ diffuse large B-cell lymphoma or follicular lymphoma: results from a prospective, randomized, open-label, crossover study (PrefMab)

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Rummel, M., Kim, T.M., Aversa, F., Brugger, W., Capochiani, E., Plenteda, C., Re, F., Trask, P. +3 more·2017·Annals of Oncology

DOI 10.1093/annonc/mdw685

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Abstract

Background The aim of this study was to evaluate patient preference and satisfaction for the subcutaneous (s.c.) versus intravenous (i.v.) formulation of rituximab given with chemotherapy in previously untreated patients with CD20+ diffuse large B-cell lymphoma (DLBCL) or follicular lymphoma (FL).Patients and methods Patients received eight cycles of rituximab according to 2 schedules: Arm A received 1 cycle rituximab i.v. (375 mg/m2) and 3 cycles rituximab s.c. (1400 mg) then 4 cycles rituximab i.v.; Arm B received 4 cycles rituximab i.v. (375 mg/m2) then 4 cycles rituximab s.c. (1400 mg). Alongside rituximab, both arms received 6-8 cycles of chemotherapy (cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP), cyclophosphamide, vincristine, prednisone (CVP), or bendamustine as per standard local practice). Preference for s.c. or i.v. administration was evaluated using the Patient Preference Questionnaire (PPQ) at cycles 6 and 8. Patient satisfaction and convenience were assessed using the Cancer Therapy Satisfaction Questionnaire (CTSQ), and Rituximab Administration Satisfaction Questionnaire (RASQ) at cycles 4 and 8.Results At the primary data cut-off (19 January 2015), the intent-to-treat population comprised 743 patients. The majority had DLBCL (63%) and baseline characteristics were balanced between arms. At cycle 8, 81% of patients completing the PPQ preferred rituximab s.c. Preference was not impacted by treatment sequence or disease type. Patient satisfaction as measured by RASQ was higher for s.c. versus i.v. CTSQ scores were similar between arms. Adverse events were generally balanced between administration routes and no new safety signals were detected.Conclusion Most previously untreated patients with CD20+ DLBCL or FL preferred s.c. to i.v. rituximab administration. Patient satisfaction with rituximab treatment was generally greater with s.c. administration.Registered clinical trial number NCT01724021 (ClinicalTrials.gov).

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The most common reasons for preference for subcutaneous rituximab were less time required in the clinic and increased comfort with subcutaneous administration.
“The most common reasons for the preference were less time required in the clinic and increased comfort with subcutaneous administration [55].”
From Subcutaneous Administration of Biotherapeutics: An Overview of Current Challenges and Opportunities (2018) · cites this paper as [55]
In the PrefMab study, the majority of patients preferred subcutaneous over intravenous rituximab therapy, regardless of whether they received subcutaneous rituximab during the first or second part of the study; 79-81% expressed an overall preference for subcutaneous administration at cycle 6 and 77-84% at cycle 8.
“The majority of patients preferred subcutaneous over intravenous rituximab therapy, regardless of whether they received subcutaneous rituximab during the first or second part of the study; 79–81% expressed an overall preference for subcutaneous administration at cycle 6 and 77–84% at cycle 8.”
From Subcutaneous Administration of Biotherapeutics: An Overview of Current Challenges and Opportunities (2018) · cites this paper as [55]

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Prefmab: Final Analysis of Patient Preference for Subcutaneous Versus Intravenous Rituximab in Previously Untreated CD20+ Diffuse Large B-Cell Lymphoma and Follicular Lymphoma
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Prefmab: Final Analysis Of Patient Satisfaction With Subcutaneous Versus Intravenous Rituximab In Previously Untreated Cd20+ Diffuse Large B-Cell Lymphoma Or Follicular Lymphoma
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Preference for Rituximab Subcutaneous (Sc) and Intravenous (Iv) Among Patients With Cd20+ Non-Hodgkin's Lymphoma (Nhl) Completing the Rasq Measure In Randomized Phase Iii Studies Prefmab and Mabcute
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Self-citation
Subcutaneous versus intravenous rituximab administration in first-line diffuse large B-cell lymphoma and follicular lymphona: Prefmab study of patient preference and satisfaction in 19 countries
Rummel, M., Kim, T. M., Jensen, P., Pereira, W. V., Re, F. D., Mendoza, M. B., Osborne, S., Smith, R. L., & Grigg, A. (2016) · VBN Forskningsportal (Aalborg Universitet)
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Authors: Rummel, M., Kim, T. M., Aversa, F., Brugger, W., Capochiani, E., Plenteda, C., Re, F., Trask, P., Osborne, S., Smith, R., & Grigg, A.
Affiliations: Universitätsklinikum Gießen und Marburg (DE)
Seoul National University Hospital (KR)
University of Parma (IT)
University of Freiburg (DE)
Ospedale di Livorno (IT)
Genentech (US)
F. Hoffmann-La Roche AG (CH)
Austin Hospital (AU)
Corresponding author: Rummel, M.
ORCID: Rummel, M.
Kim, T.M.
Aversa, F.
Capochiani, E.
Grigg, A.
Venue: Annals of Oncology
Publisher: Elsevier BV
Published: 2017-04
Volume: 28
Issue: 4
Pages: 836-842
ISSN: 0923-7534 (ISSN-L)
DOI: 10.1093/annonc/mdw685
OpenAlex: W2566995909
Cited by: 154
References: 15
Citations by year: 2026: 16 · 2025: 30 · 2024: 20 · 2023: 18 · 2022: 10 · 2021: 22 · 2020: 9 · 2019: 11 · 2018: 10 · 2017: 7 · 2016: 1
FWCI: 8.77
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 942 d)
Locations: Annals of Oncology (publishedVersion)
PubMed (publishedVersion)
Funders: F. Hoffmann-La Roche Ltd
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
Keywords: rituximab, subcutaneous administration, intravenous administration, patient preferences, patient satisfaction, diffuse large B-cell lymphoma, follicular lymphoma, CD20-positive lymphoma, CHOP chemotherapy, bendamustine, treatment-naive patients, crossover trial, adverse events
MeSH terms: Rituximab, Adult, Aged, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Female, Humans, Infusions, Intravenous, Lymphoma, Follicular, Male, Middle Aged, Prospective Studies, Lymphoma, Large B-Cell, Diffuse, Cross-Over Studies, Infusions, Subcutaneous, Patient Preference

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Preference for subcutaneous or intravenous administration of rituximab among patients with untreated CD20+ diffuse large B-cell lymphoma or follicular lymphoma: results from a prospective, randomized, open-label, crossover study (PrefMab)

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