Prospective, randomized, comparative study of the cutaneous effects of a topical body treatment compared to a bland moisturizer
Open accessAbstract
BACKGROUND: Over time human skin thins and loses elasticity; topical treatments attempt to reverse this process. OBJECTIVES: The aim of this study was to assess the efficacy of TransFORM Body Treatment (TFB) in skin rejuvenation compared to a bland moisturizer on the extensor and volar forearms. METHODS: Blinded participants were given 2 products to apply on the designated forearms with follow-up at 4, 8, and 12 weeks. Measurements included skin thickness, photography, dermatopathology, cutaneous elasticity determined by 2 different methods, and patient-reported outcomes. All were compared to baseline. RESULTS: Changes between bland moisturizer and TFB were recorded for the following parameters. (1) Roughness: extensor -0.09 mm for bland moisturizer and -0.26 mm for TFB (P = 0.174); volar 0.01 mm for bland moisturizer and -0.23 mm for TFB (P = 0.004). (2) Recoil velocity: volar -56°/sec for bland moisturizer and -24°/sec for TFB (P = 0.61); extensor -95°/sec for bland moisturizer and -63°/sec for TFB (P = 0.57). Retraction speed: volar -3.25 ms for bland moisturizer and -20.08 ms for TFB (P = 0.33); extensor -2.17 ms for bland moisturizer and -10.83 ms for TFB (P = 0.66). Histologically, TFB resulted in an increase in mucopolysaccharide content, new collagen, and number of elastin fibers in the papillary dermis. Changes in the Rao-Goldman score were also observed: volar -0.17 for bland moisturizer and -0.33 for TFB (P = 0.25); extensor -0.08 for bland moisturizer and -0.17 for TFB (P = 0.36). CONCLUSIONS: Histology showed production of new collagen and elastin. Quantification of changes in skin thickness, skin retraction speed, and skin recoil velocity showed trends that agree with the visual data.
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Common protocols or approaches among Gen Z seeking to maintain a youthful appearance include noninvasive cosmetic procedures (dermal fillers, laser skin rejuvenation, microdermabrasion, chemical peels), skincare routines, healthy lifestyle choices, and social media beauty trends (viral skincare routines, face masks, innovative beauty gadgets).
“Some common protocols or approaches include noninvasive cosmetic procedures, such as dermal fillers, laser skin rejuvenation, microdermabrasion, chemical peels, skincare routines to maintain a youthful glow, healthy lifestyle choices, and social media beauty trends, including viral skincare routines, face masks, and innovative beauty gadgets.6‐8”
From Prejuvenation: The Global New Anti-Aging Trend (2023) · cites this paper as [6]
The Discussion’s “Prejuvenation” section supports preventive skincare: it discusses sunscreen and topical treatments to maintain youthful skin. The paper does not address Gen Z’s commonly used approaches, the listed cosmetic procedures, healthy lifestyle choices beyond sun protection, or social-media beauty trends. Our copy provides section labels but no page numbers. (LLM, conf=0.87)
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Cites
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Self-citationNon-Surgical Fat Reduction and Topical Modulation of Adipose Tissue Physiology
Widgerow, A. D., Kilmer, S. L., Garruto, J. A., et al. (2019) · PubMed · Cited by 21 · see citing works
Self-citationWidgerow, A. D., Moradi, A., & Poehler, J. (2019) · PubMed · Cited by 20 · see citing works
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Prejuvenation: The Global New Anti-Aging Trend
Haykal, D., Nahai, F., & Cartier, H. (2023) · Aesthetic Surgery Journal Open Forum · doi:10.1093/asjof/ojad061 · Cited by 24 · see citing works
“skincare routines to maintain a youthful glow, healthy lifestyle choices, and social media beauty trends, including viral skincare routines, face masks, and innovative beauty gadgets.(6-8) While prejuvenation offers numerous benefits, it is crucial to clarify to patients that it can slow down the aging process but not…”
Background
- Authors
- Carruthers, J., Bourne, G., Bell, M., & Widgerow, A.
- Affiliations
- Carruthers Instruments Inc., Vancouver, British Columbia, Canada
- Alastin Skincare, Inc., Carlsbad, CA, USA
- Corresponding author
- Carruthers, Jean
- Venue
- Aesthetic Surgery Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2021-04-02
- Volume
- 41
- Issue
- 9
- Pages
- NP1188-NP1198
- ISSN
- 1090-820X (ISSN-L)
- 1527-330X
- PMC
- PMC8361352
- OpenAlex
- W3147410779
- Cited by
- 5
- References
- 12
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 1 · 2022: 1
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Aesthetic Surgery Journal (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- Alastin Skin Care Inc.
- Carruthers Instruments Inc
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- skin rejuvenation, emollients, skin thickness, skin elasticity, skin roughness, collagen, elastin, glycosaminoglycans, papillary dermis, forearm skin, skin aging
- MeSH terms
- Administration, Cutaneous, Humans, Prospective Studies, Skin, Treatment Outcome
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