Attention-based generative adversarial networks improve prognostic outcome prediction of cancer from multimodal data
Open accessAbstract
The prediction of prognostic outcome is critical for the development of efficient cancer therapeutics and potential personalized medicine. However, due to the heterogeneity and diversity of multimodal data of cancer, data integration and feature selection remain a challenge for prognostic outcome prediction. We proposed a deep learning method with generative adversarial network based on sequential channel-spatial attention modules (CSAM-GAN), a multimodal data integration and feature selection approach, for accomplishing prognostic stratification tasks in cancer. Sequential channel-spatial attention modules equipped with an encoder-decoder are applied for the input features of multimodal data to accurately refine selected features. A discriminator network was proposed to make the generator and discriminator learning in an adversarial way to accurately describe the complex heterogeneous information of multiple modal data. We conducted extensive experiments with various feature selection and classification methods and confirmed that the CSAM-GAN via the multilayer deep neural network (DNN) classifier outperformed these baseline methods on two different multimodal data sets with miRNA expression, mRNA expression and histopathological image data: lower-grade glioma and kidney renal clear cell carcinoma. The CSAM-GAN via the multilayer DNN classifier bridges the gap between heterogenous multimodal data and prognostic outcome prediction.
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- Authors
- Shi, M., Li, X., Li, M., & Si, Y.
- Affiliations
- Hefei University of Technology (CN)
- Corresponding author
- Shi, Mingguang
- Venue
- Briefings in Bioinformatics
- Publisher
- Oxford University Press (OUP)
- Published
- 2023-09-22
- Volume
- 24
- Issue
- 6
- ISSN
- 1467-5463 (ISSN-L)
- 1477-4054
- OpenAlex
- W4387078521
- Cited by
- 16
- References
- 35
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 5
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Briefings in Bioinformatics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (61572166)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
- Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
- Keywords
- cancer prognosis prediction, generative adversarial networks, attention mechanism, channel and spatial attention, multimodal data integration, feature selection, prognostic stratification, microRNA expression, mRNA expression, histopathological images, lower-grade glioma, clear cell renal cell carcinoma, personalized medicine
- MeSH terms
- Carcinoma, Renal Cell, Glioma, Humans, Kidney Neoplasms, Prognosis, MicroRNAs
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