Cited by 16Gene expression and cancer classificationRadiomics and Machine Learning in Medical ImagingAI in cancer detection

Attention-based generative adversarial networks improve prognostic outcome prediction of cancer from multimodal data

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Shi, Mingguang, Li, Xuefeng, Li, Mingna, Si, Yichong·2023·Briefings in Bioinformatics

Abstract

The prediction of prognostic outcome is critical for the development of efficient cancer therapeutics and potential personalized medicine. However, due to the heterogeneity and diversity of multimodal data of cancer, data integration and feature selection remain a challenge for prognostic outcome prediction. We proposed a deep learning method with generative adversarial network based on sequential channel-spatial attention modules (CSAM-GAN), a multimodal data integration and feature selection approach, for accomplishing prognostic stratification tasks in cancer. Sequential channel-spatial attention modules equipped with an encoder-decoder are applied for the input features of multimodal data to accurately refine selected features. A discriminator network was proposed to make the generator and discriminator learning in an adversarial way to accurately describe the complex heterogeneous information of multiple modal data. We conducted extensive experiments with various feature selection and classification methods and confirmed that the CSAM-GAN via the multilayer deep neural network (DNN) classifier outperformed these baseline methods on two different multimodal data sets with miRNA expression, mRNA expression and histopathological image data: lower-grade glioma and kidney renal clear cell carcinoma. The CSAM-GAN via the multilayer DNN classifier bridges the gap between heterogenous multimodal data and prognostic outcome prediction.

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  1. Sotiriou C, Pusztai L. Gene-expression signatures in breast. Cancer 2009;360(8):790-800.
  2. Goodfellow I, Pouget-Abadie J, Mirza M, et al. Generative adver- sarial nets. Advances in neural information processing systems, Neural Information Processing Systems Foundation, Montreal, Quebec, Canada, 2014, 2672-80.

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Authors
Shi, M., Li, X., Li, M., & Si, Y.
Affiliations
Hefei University of Technology (CN)
Corresponding author
Shi, Mingguang
Venue
Briefings in Bioinformatics
Published
2023-09-22
Volume
24
Issue
6
ISSN
  • 1467-5463 (ISSN-L)
  • 1477-4054
OpenAlex
W4387078521
Cited by
16
References
35
Citations by year
2026: 3 · 2025: 8 · 2024: 5
FWCI
1.42
Type
journal article
Language
en
Open access
Locations
  • Briefings in Bioinformatics (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (61572166)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
  • Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
Keywords
cancer prognosis prediction, generative adversarial networks, attention mechanism, channel and spatial attention, multimodal data integration, feature selection, prognostic stratification, microRNA expression, mRNA expression, histopathological images, lower-grade glioma, clear cell renal cell carcinoma, personalized medicine
MeSH terms
Carcinoma, Renal Cell, Glioma, Humans, Kidney Neoplasms, Prognosis, MicroRNAs

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