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Phylogenomic analysis of bacterial and archaeal sequences with AMPHORA2

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Wu, Martin, Scott, Alexandra J.·2012·Bioinformatics

Abstract

Summary: With the explosive growth of bacterial and archaeal sequence data, large-scale phylogenetic analyses present both opportunities and challenges. Here we describe AMPHORA2, an automated phylogenomic inference tool that can be used for high-throughput, high-quality genome tree reconstruction and metagenomic phylotyping. Compared with its predecessor, AMPHORA2 has several major enhancements and new functions: it has a greatly expanded phylogenetic marker database and can analyze both bacterial and archaeal sequences; it incorporates probability-based sequence alignment masks that improve the phylogenetic accuracy; it can analyze DNA as well as protein sequences and is more sensitive in marker identification; finally, it is over 100× faster in metagenomic phylotyping. Availability: http://wolbachia.biology.virginia.edu/WuLab/Software.html. Contact: mw4yv@virginia.edu Supplementary information: Supplementary data are available at Bioinformatics online.

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Metadata

Authors
Wu, M., & Scott, A. J.
Venue
Bioinformatics
Published
2012-02-12
Volume
28
Issue
7
Pages
1033-1034
ISSN
  • 1367-4803 (ISSN-L)
  • 1367-4811
OpenAlex
W2112419798
Cited by
452
References
1
FWCI
8.95
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Phylogenomic analysis of bacterial and archaeal sequences with AMPHORA2. https://app.cochat.ai/papers/10.1093/bioinformatics/bts079
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Wu, M., & Scott, A. J. (2012). Phylogenomic analysis of bacterial and archaeal sequences with AMPHORA2. Bioinformatics. https://doi.org/10.1093/bioinformatics/bts079

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