Cited by 1,065Airway Management and Intubation TechniquesPatient Safety and Medication ErrorsAnesthesia and Sedative Agents

Major complications of airway management in the UK: results of the Fourth National Audit Project of the Royal College of Anaesthetists and the Difficult Airway Society. Part 2: intensive care and emergency departments

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Cook, T.M., Woodall, N., Harper, J., Benger, J.·2011·British Journal of Anaesthesia

Abstract

Background The Fourth National Audit Project of the Royal College of Anaesthetists and Difficult Airway Society (NAP4) was designed to identify and study serious airway complications occurring during anaesthesia, in intensive care unit (ICU) and the emergency department (ED). Methods Reports of major complications of airway management (death, brain damage, emergency surgical airway, unanticipated ICU admission, prolonged ICU stay) were collected from all National Health Service hospitals over a period of 1 yr. An expert panel reviewed inclusion criteria, outcome, and airway management. Results A total of 184 events met inclusion criteria: 36 in ICU and 15 in the ED. In ICU, 61% of events led to death or persistent neurological injury, and 31% in the ED. Airway events in ICU and the ED were more likely than those during anaesthesia to occur out-of-hours, be managed by doctors with less anaesthetic experience and lead to permanent harm. Failure to use capnography contributed to 74% of cases of death or persistent neurological injury. Conclusions At least one in four major airway events in a hospital are likely to occur in ICU or the ED. The outcome of these events is particularly adverse. Analysis of the cases has identified repeated gaps in care that include: poor identification of at-risk patients, poor or incomplete planning, inadequate provision of skilled staff and equipment to manage these events successfully, delayed recognition of events, and failed rescue due to lack of or failure of interpretation of capnography. The project findings suggest avoidable deaths due to airway complications occur in ICU and the ED.

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  • The use of sedation is not routine, and has been associated with increased awake intubation failures.

    “The use of sedation is not routine, and has been associated with increased awake intubation failures.74”

    From Airway Management in Trauma (2018) · cites this paper as [74]

    The Primary airway problem and What do we learn from these observations? sections discuss failed intubation in ICU and emergency departments, but do not identify awake intubation failures or link them to sedation. Searches for awake intubation and sedation found references to sedation holds and tube displacement, not evidence that sedation is non-routine or associated with increased awake intubation failures. Page numbers were unavailable in our copy. (LLM, conf=0.76)

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Authors
Cook, T. M., Woodall, N., Harper, J., & Benger, J.
Affiliations
  • Royal United Hospital (GB)
  • Norfolk and Norwich University Hospitals NHS Foundation Trust (GB)
  • Royal Liverpool University Hospital (GB)
  • University of the West of England (GB)
Corresponding author
Cook, T.M.
Venue
British Journal of Anaesthesia
Publisher
Elsevier BV
Published
2011-05
Volume
106
Issue
5
Pages
632-642
ISSN
0007-0912 (ISSN-L)
OpenAlex
W2098262035
Cited by
1,065
References
0
Citations by year
2026: 66 · 2025: 73 · 2024: 65 · 2023: 72 · 2022: 76 · 2021: 70 · 2020: 72 · 2019: 63 · 2018: 71 · 2017: 63 · 2016: 122 · 2015: 64 · 2014: 60 · 2013: 46 · 2012: 47
FWCI
78.05
Type
journal article
Language
en
Open access
Locations
  • British Journal of Anaesthesia (publishedVersion)
  • PubMed (publishedVersion)
  • UWE Research Repository (UWE Bristol) (submittedVersion, cc-by)
Funders
  • Association of Anaesthetists of Great Britain
  • University of Bath
  • Intensive Care Society
  • Royal College of Anaesthetists
  • College of Emergency Medicine
  • Association of Anaesthetists
Topics
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Airway Management and Intubation Techniques
  • Health Sciences › Health Professions › Emergency Medical Services › Patient Safety and Medication Errors
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
Keywords
airway management complications, difficult airway, intensive care unit, emergency department, capnography, neurological injury, patient death, emergency surgical airway, out-of-hours care, high-risk patient identification, avoidable harm
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Airway Obstruction, Hypoxia, Brain, Child, Emergencies, Emergency Service, Hospital, Female, United Kingdom, Humans, Intensive Care Units, Male, Medical Audit, Middle Aged, Prospective Studies, Risk Factors, State Medicine, Airway Management

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