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NATURAL HISTORY OF ASYMPTOMATIC EXTRACRANIAL ARTERIAL DISEASE: RESULTS OF A LONG-TERM PROSPECTIVE STUDY
Abstract
The natural history of asymptomatic extracranial arterial disease (EAD) was studied prospectively in 339 patients admitted for serial ultrasound Doppler examinations. Annual mortality was high at 7%, but stroke mortality was low at 0.6%: 82 patients (24%) died during the follow-up period, which lasted up to seven years (median: 29 months), only 10 from stroke but 41 from cardiac causes. The risk of suffering a stroke without premonitory transient ischaemic attacks (TIAs) was similarly low at 0.4%. Progression of EAD was the only predictor established to indicate the individual patient's cerebrovascular prognosis among a series of criteria tested (age, sex, degree and extent of carotid and/or vertebral disease, risk factors and indicators of atherosclerosis). Deterioration of EAD was observed in 108 (36%) of 296 patients by repeated Doppler examination, 174 (59%) remained constant and 14 (5%) showed an improvement. The observed low rate of strokes without premonitory TIAs is not in favour for early carotid endarterectomy in the majority of neurologically asymptomatic patients.
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Cited by
de Weerd, M., Greving, J. P., Hedblad, B., Lorenz, M. W., Mathiesen, E. B., O'Leary, D. H., Rosvall, M., Sitzer, M., Buskens, E., & Bots, M. L. (2010) · Stroke · doi:10.1161/strokeaha.110.581058 · Cited by 435
Risk of stroke in the distribution of an asymptomatic carotid artery
(1995) · The Lancet · doi:10.1016/s0140-6736(95)90220-1 · Cited by 312
Zhan, C., Shi, M., Yang, Y., Pang, H., Fei, S., Bai, L., Liu, B., Tu, J., Huo, Y., Ning, X., et al. (2016) · Scientific Reports · doi:10.1038/srep23870 · Cited by 41
Liu, J., Zhu, Y., Wu, Y., Liu, Y., Teng, Z., & Hao, Y. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s124386 · Cited by 22
Metadata
- Authors
- HENNERICI, M., HÜLSBÖMER, H.-B., HEFTER, H., LAMMERTS, D., & RAUTENBERG, W.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 1987
- Volume
- 110
- Issue
- 3
- Pages
- 777-791
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W1964413620
- Cited by
- 312
- References
- 0
- FWCI
- 11.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: NATURAL HISTORY OF ASYMPTOMATIC EXTRACRANIAL ARTERIAL DISEASE: RESULTS OF A LONG-TERM PROSPECTIVE STUDY. https://app.cochat.ai/papers/10.1093/brain/110.3.777
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- HENNERICI, M., HÜLSBÖMER, H.-B., HEFTER, H., LAMMERTS, D., & RAUTENBERG, W. (1987). NATURAL HISTORY OF ASYMPTOMATIC EXTRACRANIAL ARTERIAL DISEASE: RESULTS OF A LONG-TERM PROSPECTIVE STUDY. Brain. https://doi.org/10.1093/brain/110.3.777
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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