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COMPARISON OF CORTICAL AND SUBCORTICAL LESIONS IN THE PRODUCTION OF POSTSTROKE MOOD DISORDERS
Abstract
Patients with single stroke lesions, verified by computerized tomography, involving either cortical tissue or restricted entirely to subcortical structures were examined for mood disorders. Those with left anterior lesions, either cortical or subcortical, had significantly greater frequency and severity of depression than patients with any other lesion location. A strong correlation between the severity of depression and proximity of the lesion to the frontal pole was observed for both left cortical and subcortical groups. Right hemisphere lesions did not show the same correlation with depression but were associated with a significantly higher incidence of undue cheerfulness. These findings demonstrate the importance of the location of subcortical lesions in poststroke mood disorders and suggest that anterior subcortical structures may play an important but lateralized role in the production or regulation of mood.
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Citations
Cited by
Frontal-subcortical circuits and human behavior
Cummings, J. L. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540080076020 · Cited by 2,262
Limbic-cortical dysregulation: a proposed model of depression
(1997) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.9.3.471 · Cited by 1,585
Wager, T. D., Phan, K. L., Liberzon, I., & Taylor, S. F. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00078-8 · Cited by 1,150
Limbic-frontal circuitry in major depression: a path modeling metanalysis
Seminowicz, D. A., Mayberg, H. S., McIntosh, A. R., Goldapple, K., Kennedy, S., Segal, Z., & Rafi-Tari, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.01.015 · Cited by 710
The regulation of sleep and arousal: development and psychopathology
Dahl, R. E. (1996) · Development and Psychopathology · doi:10.1017/s0954579400006945 · Cited by 707
Metadata
- Authors
- STARKSTEIN, S. E., ROBINSON, R. G., & PRICE, T. R.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 1987
- Volume
- 110
- Issue
- 4
- Pages
- 1045-1059
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2035471419
- Cited by
- 421
- References
- 0
- FWCI
- 20.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: COMPARISON OF CORTICAL AND SUBCORTICAL LESIONS IN THE PRODUCTION OF POSTSTROKE MOOD DISORDERS. https://app.cochat.ai/papers/10.1093/brain/110.4.1045
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- STARKSTEIN, S. E., ROBINSON, R. G., & PRICE, T. R. (1987). COMPARISON OF CORTICAL AND SUBCORTICAL LESIONS IN THE PRODUCTION OF POSTSTROKE MOOD DISORDERS. Brain. https://doi.org/10.1093/brain/110.4.1045
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.