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COMPARISON OF CORTICAL AND SUBCORTICAL LESIONS IN THE PRODUCTION OF POSTSTROKE MOOD DISORDERS

STARKSTEIN, SERGIO E., ROBINSON, ROBERT G., PRICE, THOMAS R.·1987·Brain

Abstract

Patients with single stroke lesions, verified by computerized tomography, involving either cortical tissue or restricted entirely to subcortical structures were examined for mood disorders. Those with left anterior lesions, either cortical or subcortical, had significantly greater frequency and severity of depression than patients with any other lesion location. A strong correlation between the severity of depression and proximity of the lesion to the frontal pole was observed for both left cortical and subcortical groups. Right hemisphere lesions did not show the same correlation with depression but were associated with a significantly higher incidence of undue cheerfulness. These findings demonstrate the importance of the location of subcortical lesions in poststroke mood disorders and suggest that anterior subcortical structures may play an important but lateralized role in the production or regulation of mood.

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Metadata

Authors
STARKSTEIN, S. E., ROBINSON, R. G., & PRICE, T. R.
Venue
Brain
Published
1987
Volume
110
Issue
4
Pages
1045-1059
ISSN
  • 0006-8950 (ISSN-L)
  • 1460-2156
OpenAlex
W2035471419
Cited by
421
References
0
FWCI
20.36
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: COMPARISON OF CORTICAL AND SUBCORTICAL LESIONS IN THE PRODUCTION OF POSTSTROKE MOOD DISORDERS. https://app.cochat.ai/papers/10.1093/brain/110.4.1045
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STARKSTEIN, S. E., ROBINSON, R. G., & PRICE, T. R. (1987). COMPARISON OF CORTICAL AND SUBCORTICAL LESIONS IN THE PRODUCTION OF POSTSTROKE MOOD DISORDERS. Brain. https://doi.org/10.1093/brain/110.4.1045

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